Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells. (Q35816898)

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scientific article published in October 2015

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English	Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells.	scientific article published in October 2015

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27 February 2020

Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells (English)

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27 February 2020

Human Induced Pluripotent Stem Cells

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neurodegeneration

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Marija Usenovic

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Shahriar Niroomand

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Robert E Drolet

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Lihang Yao

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Renee C Gaspar

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Nathan G Hatcher

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Joel Schachter

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John J Renger

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Sophie Parmentier-Batteur

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1 October 2015

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27 February 2020

Journal of Neuroscience

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27 February 2020

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27 February 2020

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27 February 2020

[18] Quantification of β-sheet amyloid fibril structures with thioflavin T

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https://pubmed.ncbi.nlm.nih.gov/26490863

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Quantification of protein-protein interactions using fluorescence polarization

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Conformational change as one of the earliest alterations of tau in Alzheimer's disease.

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

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12 December 2020

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Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease.

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12 December 2020

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Tau aggregation in the hippocampal formation: an ageing or a pathological process?

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Fluorescence polarization: past, present and future

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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12 December 2020

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The calpains in aging and aging-related diseases

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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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12 December 2020

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Transgenic animal models of tauopathies

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A microfluidic culture platform for CNS axonal injury, regeneration and transport

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12 December 2020

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Rapamycin alleviates toxicity of different aggregate-prone proteins

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12 December 2020

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Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease

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Immunoassays with direct mass spectrometric detection

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https://pubmed.ncbi.nlm.nih.gov/26490863

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Characteristics of the binding of thioflavin S to tau paired helical filaments.

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12 December 2020

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Characterization of two VQIXXK motifs for tau fibrillization in vitro

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Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

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12 December 2020

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Accumulation of pathological tau species and memory loss in a conditional model of tauopathy.

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https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

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Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

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https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

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Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/26490863

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The distribution of synapsin I and synaptophysin in hippocampal neurons developing in culture

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Propagation of tau misfolding from the outside to the inside of a cell.

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Transmission and spreading of tauopathy in transgenic mouse brain

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Reactivity and applications of new amine reactive cross-linkers for mass spectrometric detection of protein-protein complexes

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12 December 2020

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The dysregulation of intracellular calcium in Alzheimer disease

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Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles

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Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II calcium/calmodulin-dependent protein kinase

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12 December 2020

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Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease.

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Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice.

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Autophagy in protein and organelle turnover

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Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

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12 December 2020

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Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles.

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12 December 2020

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Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

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Propagation of tau pathology in a model of early Alzheimer's disease

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Trans-cellular propagation of Tau aggregation by fibrillar species

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Paired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomes

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Constitutive secretion of tau protein by an unconventional mechanism.

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Biochemistry and cell biology of tau protein in neurofibrillary degeneration

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Characterizing human ion channels in induced pluripotent stem cell-derived neurons

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Guidelines for the use and interpretation of assays for monitoring autophagy

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FTDP-17 tau mutations induce distinct effects on aggregation and microtubule interactions

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Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

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Cellular mechanisms of protein aggregate propagation

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Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

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Prevention of β-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events.

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12 December 2020

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Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy

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12 December 2020

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Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau.

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Physiological release of endogenous tau is stimulated by neuronal activity.

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A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss

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https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

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Brain homogenates from human tauopathies induce tau inclusions in mouse brain

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Fluorescence Polarization (FP) Assays for Monitoring Peptide-Protein or Nucleic Acid-Protein Binding

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12 December 2020

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Formation and propagation of tau oligomeric seeds

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Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

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Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

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Intercellular transfer of tau aggregates and spreading of tau pathology: Implications for therapeutic strategies

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Thymoquinone protects cultured hippocampal and human induced pluripotent stem cells-derived neurons against α-synuclein-induced synapse damage

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12 December 2020

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Pharmacological characterisation of ligand- and voltage-gated ion channels expressed in human iPSC-derived forebrain neurons

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12 December 2020

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Conformation determines the seeding potencies of native and recombinant Tau aggregates

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Rapamycin ester analog CCI-779/Temsirolimus alleviates tau pathology and improves motor deficit in mutant tau transgenic mice

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12 December 2020

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Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease

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12 December 2020

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Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation.

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Staging of Alzheimer's disease-related neurofibrillary changes

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Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau.

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12 December 2020

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Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

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12 December 2020

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10.1523/JNEUROSCI.1523-15.2015

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