Streptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells (Q35818866)

10 August 2017

Streptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells (English)

1 reference

10 August 2017

0 references

Streptococcus pneumoniae

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26080406%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Vincent T K Chow

8

1 reference

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13 June 2020

author name string

Marcus Parrish

2

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13 June 2020

Ian Jun Jie Tay

3

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13 June 2020

Na Li

4

1 reference

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13 June 2020

Shelley Ackerman

5

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13 June 2020

Fang He

6

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13 June 2020

Jimmy Kwang

7

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13 June 2020

Bevin P Engelward

9

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13 June 2020

language of work or name

English

0 references

publication date

15 June 2015

1 reference

Proceedings of the National Academy of Sciences of the United States of America

10 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26080406%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

112

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13 June 2020

issue

26

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13 June 2020

page(s)

E3421-30

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Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts

13 June 2020

cites work

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Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA-PK

11 July 2018

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Effect of the 2009 influenza A(H1N1) pandemic on invasive pneumococcal pneumonia

11 July 2018

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Changes in capsular serotype alter the surface exposure of pneumococcal adhesins and impact virulence

11 July 2018

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11 July 2018

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Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells

11 July 2018

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Two-phase dynamics of p53 in the DNA damage response.

11 July 2018

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Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epithelial cells and in mice

11 July 2018

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MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair

11 July 2018

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Helicobacter hepaticus cytolethal distending toxin causes cell death in intestinal epithelial cells via mitochondrial apoptotic pathway

11 July 2018

1 reference

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A minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaks

11 July 2018

1 reference

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The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks

11 July 2018

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Pathogenesis, treatment, and prevention of pneumococcal pneumonia

11 July 2018

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Mechanisms of neutrophil accumulation in the lungs against bacteria

11 July 2018

1 reference

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Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness

11 July 2018

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Mycoplasma pneumoniae infection induces reactive oxygen species and DNA damage in A549 human lung carcinoma cells

11 July 2018

1 reference

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Mechanistic studies on bleomycin-mediated DNA damage: multiple binding modes can result in double-stranded DNA cleavage

11 July 2018

1 reference

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Recombinant adeno-associated viral vectors are deficient in provoking a DNA damage response

11 July 2018

1 reference

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Protein kinase C protects from DNA damage-induced necrotic cell death by inhibiting poly(ADP-ribose) polymerase-1

11 July 2018

1 reference

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ShRNA-mediated Ku80 gene silencing inhibits cell proliferation and sensitizes to gamma-radiation and mitomycin C-induced apoptosis in esophageal squamous cell carcinoma lines

11 July 2018

1 reference

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Influence of the spxB gene on competence in Streptococcus pneumoniae

11 July 2018

1 reference

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SpxB is a suicide gene of Streptococcus pneumoniae and confers a selective advantage in an in vivo competitive colonization model

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491788

DNA double-strand break repair: from mechanistic understanding to cancer treatment

11 July 2018

1 reference

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The role of pneumolysin in mediating lung damage in a lethal pneumococcal pneumonia murine model

11 July 2018

1 reference

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ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491788

Neutrophils and respiratory tract DNA damage and mutagenesis: a review

11 July 2018

1 reference

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Insights into the interaction between influenza virus and pneumococcus

11 July 2018

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Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3.

11 July 2018

1 reference

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H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks

11 July 2018

1 reference

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The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease

11 July 2018

1 reference

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

11 July 2018

1 reference

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Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium

11 July 2018

1 reference

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In vitro and in vivo characterization of Helicobacter hepaticus cytolethal distending toxin mutants

11 July 2018

1 reference

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Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains

11 July 2018

1 reference

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Factors contributing to hydrogen peroxide resistance in Streptococcus pneumoniae include pyruvate oxidase (SpxB) and avoidance of the toxic effects of the fenton reaction

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491788

DNA damage-triggered apoptosis: critical role of DNA repair, double-strand breaks, cell proliferation and signaling

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491788

Oxidative DNA damage: mechanisms, mutation, and disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491788

Accumulation of Checkpoint Protein 53BP1 at DNA Breaks Involves Its Binding to Phosphorylated Histone H2AX

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491788

Resistance among Streptococcus pneumoniae: Implications for drug selection

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491788

Recombination at double-strand breaks and DNA ends: conserved mechanisms from phage to humans.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491788

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491788

The autolytic enzyme LytA of Streptococcus pneumoniae is not responsible for releasing pneumolysin

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491788

Development of a new experimental model of penicillin-resistant Streptococcus pneumoniae pneumonia and amoxicillin treatment by reproducing human pharmacokinetics.

11 July 2018

1 reference

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Plasma membrane phospholipid asymmetry precedes DNA fragmentation in different apoptotic cell models

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491788

Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development

11 July 2018

1 reference

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Differences in virulence for mice among Streptococcus pneumoniae strains of capsular types 2, 3, 4, 5, and 6 are not attributable to differences in pneumolysin production.

11 July 2018

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On the role of DNA double-strand breaks in toxicity and carcinogenesis

11 July 2018

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Pyruvate oxidase, as a determinant of virulence in Streptococcus pneumoniae

11 July 2018

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Uptake of Streptococcus pneumoniae by respiratory epithelial cells

11 July 2018

1 reference

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Molecular analysis of the pathogenicity of Streptococcus pneumoniae: the role of pneumococcal proteins

11 July 2018

1 reference

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Interactions of oxygen radicals with airway epithelium

11 July 2018

1 reference

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Molecular cloning, characterization, and complete nucleotide sequence of the gene for pneumolysin, the sulfhydryl-activated toxin of Streptococcus pneumoniae

11 July 2018

1 reference

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Effects of immunocompromise and comorbidities on pneumococcal serotypes causing invasive respiratory infection in adults: implications for vaccine strategies

11 July 2018

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Adjunctive N-acetyl-L-cysteine in treatment of murine pneumococcal meningitis

24 September 2018

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Pneumococcal serotypes before and after introduction of conjugate vaccines, United States, 1999-2011(1.).

24 September 2018

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Clinical and economic burden of pneumococcal disease in older US adults.

24 September 2018

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Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase

24 September 2018

1 reference

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Streptococcus pneumoniae R6x induced p38 MAPK and JNK-mediated caspase-dependent apoptosis in human endothelial cells.

24 September 2018

1 reference

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Tissue-specific contributions of pneumococcal virulence factors to pathogenesis

24 September 2018

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Streptococcus pneumoniae-associated human macrophage apoptosis after bacterial internalization via complement and Fcgamma receptors correlates with intracellular bacterial load.

24 September 2018

1 reference

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Two distinct mechanisms for induction of dendritic cell apoptosis in response to intact Streptococcus pneumoniae

24 September 2018

1 reference

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Microbiological and inflammatory factors associated with the development of pneumococcal pneumonia.

24 September 2018

1 reference

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Effects of Clinically Used Antioxidants in Experimental Pneumococcal Meningitis

24 September 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1424144112

Serotypes and genotypes of Streptococcus pneumoniae causing pneumonia and acute exacerbations in patients with chronic obstructive pulmonary disease

21 January 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1424144112

Modulation of the Inflammatory Response toStreptococcus pneumoniaein a Model of Acute Lung Tissue Infection

21 January 2018

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12 December 2020

Comparison of pulmonary inflammatory and antioxidant responses to intranasal live and heat-killed Streptococcus pneumoniae in mice

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12 December 2020

Differential patterns of apoptosis in resolving and nonresolving bacterial pneumonia

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12 December 2020

Induction of necrosis and apoptosis of neutrophil granulocytes by Streptococcus pneumoniae

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12 December 2020

Epidemiologic studies of Streptococcus pneumoniae in infants: acquisition, carriage, and infection during the first 24 months of life

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1424144112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26080406%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26080406%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference