A new modality for immunosuppression: targeting the JAK/STAT pathway (Q35825869)

10 August 2017

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title

A new modality for immunosuppression: targeting the JAK/STAT pathway (English)

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10 August 2017

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John J O'Shea

1

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10 August 2017

Marko Pesu

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2

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10 August 2017

Dominic C Borie

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3

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10 August 2017

Paul S Changelian

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4

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10 August 2017

1 July 2004

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Nature Reviews Drug Discovery

10 August 2017

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10 August 2017

3

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10 August 2017

555-564

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10 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nrd1441

10 August 2017

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21 January 2018

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Genetic models of abnormal apoptosis in lymphocytes

31 March 2020

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Protein kinase C inhibitors as novel anticancer drugs

31 March 2020

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Role of Janus kinase 3 in mast cell-mediated innate immunity against gram-negative bacteria

31 March 2020

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CD40 triggered human monocyte-derived dendritic cells convert to tolerogenic dendritic cells when JAK3 activity is inhibited

31 March 2020

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Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.

31 March 2020

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Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells

31 March 2020

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The use of antibodies against the IL-2 receptor in transplantation

31 March 2020

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Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology

31 March 2020

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Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells

31 March 2020

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Immune response in Stat2 knockout mice

31 March 2020

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Targeting Janus kinase 3 to attenuate the severity of acute graft-versus-host disease across the major histocompatibility barrier in mice

31 March 2020

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Treatment of post-bone marrow transplant acute graft-versus-host disease with a rationally designed JAK3 inhibitor

31 March 2020

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Janus kinase 3 inhibitor WHI-P131/JANEX-1 prevents graft-versus-host disease but spares the graft-versus-leukemia function of the bone marrow allografts in a murine bone marrow transplantation model

31 March 2020

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A specific inhibitor of janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosis

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD1441

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Dimensions Publication ID

10 August 2017

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