Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. (Q35832692)

10 August 2017

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. (English)

1 reference

10 August 2017

0 references

Mark Southwood

4

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Mark L Ormiston

Mark L Ormiston

2

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Rajiv Machado

Rajiv D Machado

6

0 references

Paul B Yu

Paul B Yu

14

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Nicholas W Morrell

Nicholas W Morrell

16

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Stefan Gräf

5

Stefan Gräf

1 reference

10 August 2017

Lu Long

1

1 reference

10 August 2017

Xudong Yang

3

1 reference

10 August 2017

Matthias Mueller

7

1 reference

10 August 2017

Bernd Kinzel

8

1 reference

10 August 2017

Lai Ming Yung

9

1 reference

10 August 2017

Janine M Wilkinson

10

1 reference

10 August 2017

Stephen D Moore

11

1 reference

10 August 2017

Kylie M Drake

12

1 reference

10 August 2017

Micheala A Aldred

13

1 reference

10 August 2017

Paul D Upton

15

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10 August 2017

language of work or name

English

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publication date

15 June 2015

1 reference

10 August 2017

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10 August 2017

21

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10 August 2017

7

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10 August 2017

777-785

1 reference

describes a project that uses

10 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4496295/fullTextXML

inferred from PubMed Central ID database lookup

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11 July 2018

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FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.

11 July 2018

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Anti-inflammatory and antiatherogenic role of BMP receptor II in endothelial cells

11 July 2018

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SMAD1 deficiency in either endothelial or smooth muscle cells can predispose mice to pulmonary hypertension

11 July 2018

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11 July 2018

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Altered MicroRNA processing in heritable pulmonary arterial hypertension: an important role for Smad-8

11 July 2018

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Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II.

11 July 2018

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Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension

11 July 2018

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Cellular and molecular basis of pulmonary arterial hypertension

11 July 2018

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11 July 2018

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Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

11 July 2018

1 reference

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Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension.

11 July 2018

1 reference

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Bone morphogenetic protein-9 is a circulating vascular quiescence factor

11 July 2018

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BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis

11 July 2018

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Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

11 July 2018

1 reference

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Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice

11 July 2018

1 reference

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BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk

11 July 2018

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Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery

11 July 2018

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Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia

11 July 2018

1 reference

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Role of protein kinase C isoforms in rat epididymal microvascular endothelial barrier function

11 July 2018

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Targeted mutagenesis of Smad1 reveals an essential role in chorioallantoic fusion

11 July 2018

1 reference

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Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia.

11 July 2018

1 reference

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Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in primary pulmonary hypertension

11 July 2018

1 reference

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Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family

11 July 2018

1 reference

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Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene

11 July 2018

1 reference

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BMP type II receptor is required for gastrulation and early development of mouse embryos

11 July 2018

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Mechanisms and pathology of monocrotaline pulmonary toxicity

11 July 2018

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Bone morphogenetic proteins protect pulmonary microvascular endothelial cells from apoptosis by upregulating α-B-crystallin.

11 July 2018

1 reference

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Targeted gene delivery of BMPR2 attenuates pulmonary hypertension.

24 September 2018

1 reference

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BMP9 is produced by hepatocytes and circulates mainly in an active mature form complexed to its prodomain.

24 September 2018

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Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function

24 September 2018

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Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: potential for activin receptor-like kinase-5 inhibition in prevention and progression of disease

24 September 2018

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Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: implications for familial pulmonary arterial hypertension

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496295

Re-evaluation of Evans Blue dye as a marker of albumin clearance in murine models of acute lung injury

24 September 2018

1 reference

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Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496295

Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496295

Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496295

Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496295

Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496295

Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496295

Abnormal trafficking of endogenously expressed BMPR2 mutant allelic products in patients with heritable pulmonary arterial hypertension

24 September 2018

1 reference

The ALK-1/Smad1 pathway in cardiovascular physiopathology. A new target for therapy?

21 January 2018

1 reference

Dysfunctional Smad Signaling Contributes to Abnormal Smooth Muscle Cell Proliferation in Familial Pulmonary Arterial Hypertension

21 January 2018

1 reference

A novel signaling pathway impact analysis.

21 January 2018

1 reference

Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension

21 January 2018

1 reference

Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature

21 January 2018

1 reference

Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitro

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26076038

12 December 2020

inferred from PubMed ID database lookup

Primary pulmonary hypertension

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26076038

12 December 2020

inferred from PubMed ID database lookup

Evidence that tumor necrosis factor triggers apoptosis in human endothelial cells by interleukin-1-converting enzyme-like protease-dependent and -independent pathways

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26076038

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NM.3877

1 reference

10 August 2017

1 reference

10 August 2017

PubMed publication ID

26076038

1 reference