Gating mechanism of a P2X4 receptor developed from normal mode analysis and molecular dynamics simulations (Q35837037)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22378652%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

Gating mechanism of a P2X4 receptor developed from normal mode analysis and molecular dynamics simulations (English)

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24 January 2020

3

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24 January 2020

author name string

Juan Du

series ordinal

1

1 reference

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24 January 2020

Hao Dong

series ordinal

2

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24 January 2020

language of work or name

English

0 references

publication date

29 February 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22378652%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

24 January 2020

published in

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24 January 2020

volume

109

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24 January 2020

issue

11

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24 January 2020

page(s)

4140-4145

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Activation and regulation of purinergic P2X receptor channels

24 January 2020

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Atomistic mechanism for the activation and desensitization of an AMPA-subtype glutamate receptor

27 July 2018

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Ion access pathway to the transmembrane pore in P2X receptor channels

27 July 2018

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Amino acid residues constituting the agonist binding site of the human P2X3 receptor

27 July 2018

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Structural interpretation of P2X receptor mutagenesis studies on drug action

27 July 2018

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Pore-opening mechanism in trimeric P2X receptor channels

27 July 2018

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A putative extracellular salt bridge at the subunit interface contributes to the ion channel function of the ATP-gated P2X2 receptor

27 July 2018

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New structure enlivens interest in P2X receptors.

27 July 2018

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Pore architecture and ion sites in acid-sensing ion channels and P2X receptors

27 July 2018

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Crystal structure of the ATP-gated P2X(4) ion channel in the closed state

27 July 2018

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Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism

27 July 2018

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ATP-gated P2X cation-channels

27 July 2018

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Gating the pore of P2X receptor channels

27 July 2018

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Spontaneous conformational change and toxin binding in alpha7 acetylcholine receptor: insight into channel activation and inhibition

27 July 2018

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Inter-subunit disulfide cross-linking in homomeric and heteromeric P2X receptors

27 July 2018

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Inhibition mechanism of the acetylcholine receptor by alpha-neurotoxins as revealed by normal-mode dynamics

27 July 2018

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Role of aromatic and charged ectodomain residues in the P2X(4) receptor functions

27 July 2018

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Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors

27 July 2018

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P2X receptors as cell-surface ATP sensors in health and disease

27 July 2018

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Role of ectodomain lysines in the subunits of the heteromeric P2X2/3 receptor

27 July 2018

1 reference

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Scalable molecular dynamics with NAMD

27 July 2018

1 reference

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ElNemo: a normal mode web server for protein movement analysis and the generation of templates for molecular replacement

27 July 2018

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Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations

27 July 2018

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Subunit Arrangement in P2X Receptors

27 July 2018

1 reference

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Amino acid residues involved in gating identified in the first membrane-spanning domain of the rat P2X(2) receptor

27 July 2018

1 reference

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Selectivity of diadenosine polyphosphates for rat P2X receptor subunits

27 July 2018

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Distinct ATP receptors on pain-sensing and stretch-sensing neurons.

27 July 2018

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Altered hippocampal synaptic potentiation in P2X4 knock-out mice

27 July 2018

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Signaling at purinergic P2X receptors

21 January 2018

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P2X receptors: dawn of the post-structure era.

21 January 2018

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The role of positively charged amino acids in ATP recognition by human P2X(1) receptors

21 January 2018

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ATP binding at human P2X1 receptors. Contribution of aromatic and basic amino acids revealed using mutagenesis and partial agonists

21 January 2018

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Contribution of conserved polar glutamine, asparagine and threonine residues and glycosylation to agonist action at human P2X1 receptors for ATP.

21 January 2018

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Identification of an intersubunit cross-link between substituted cysteine residues located in the putative ATP binding site of the P2X1 receptor

21 January 2018

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Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors.

21 January 2018

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Agonist trapped in ATP-binding sites of the P2X2 receptor.

21 January 2018

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Gated access to the pore of a P2X receptor: structural implications for closed-open transitions.

21 January 2018

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Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors).

21 January 2018

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Channel opening motion of alpha7 nicotinic acetylcholine receptor as suggested by normal mode analysis

21 January 2018

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Gating transition of pentameric ligand-gated ion channels

21 January 2018

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Role of the ectodomain serine 275 in shaping the binding pocket of the ATP-gated P2X3 receptor.

21 January 2018

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Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors

21 January 2018

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HOLE: a program for the analysis of the pore dimensions of ion channel structural models

21 January 2018

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AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

21 January 2018

1 reference

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Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis

24 September 2018

1 reference

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Identification of Amino Acid Residues Contributing to the ATP-binding Site of a Purinergic P2X Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1119546109

Outlines of the pore in open and closed conformations describe the gating mechanism of ASIC1

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22378652

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1119546109

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22378652%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

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release_6qybagi5ijf7lobqp2ps3me4si

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Fatcat

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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24 January 2020

PubMed publication ID

22378652

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22378652%20AND%20SRC:MED&resulttype=core&format=json