Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy (Q35839644)

10 August 2017

Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy (English)

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10 August 2017

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Rob A Cairns

1

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10 August 2017

Ioanna Papandreou

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2

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10 August 2017

Patrick D Sutphin

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3

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10 August 2017

Nicholas C Denko

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4

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10 August 2017

language of work or name

English

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publication date

15 May 2007

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10 August 2017

6

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Proceedings of the National Academy of Sciences of the United States of America

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published in

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10 August 2017

104

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10 August 2017

9445-9450

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10 August 2017

22

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describes a project that uses

10 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1890514/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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11 July 2018

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11 July 2018

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p53 regulates mitochondrial respiration

11 July 2018

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11 July 2018

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

11 July 2018

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11 July 2018

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11 July 2018

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Low-dose metronomic daily cyclophosphamide and weekly tirapazamine: a well-tolerated combination regimen with enhanced efficacy that exploits tumor hypoxia.

11 July 2018

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The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation.

11 July 2018

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11 July 2018

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Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells.

11 July 2018

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Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis

11 July 2018

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Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

11 July 2018

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11 July 2018

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11 July 2018

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Akt stimulates aerobic glycolysis in cancer cells

11 July 2018

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Exploiting tumour hypoxia in cancer treatment

11 July 2018

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Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma

11 July 2018

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Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha

11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

11 July 2018

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The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.

11 July 2018

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Hypoxic fractions of human tumors xenografted into mice: a review

11 July 2018

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Prognostic significance of [18F]-misonidazole positron emission tomography-detected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: a substudy of Trans-Tasman Radiation O

11 July 2018

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Hypoxia-inducible factor-1alpha promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts.

24 September 2018

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Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity

24 September 2018

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Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment

24 September 2018

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Tumor hypoxia is independent of hemoglobin and prognostic for loco-regional tumor control after primary radiotherapy in advanced head and neck cancer.

24 September 2018

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Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer.

24 September 2018

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Development of a hypoxia-responsive vector for tumor-specific gene therapy

24 September 2018

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Oxygen tension measurements of tumors growing in mice.

24 September 2018

1 reference

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Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin.

24 September 2018

1 reference

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Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17517659

12 December 2020

inferred from PubMed ID database lookup

Reoxygenation and rehypoxiation in the SCCVII mouse tumor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17517659

12 December 2020

inferred from PubMed ID database lookup

Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17517659

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.0611662104

1 reference

release_5spfbg2j3nfy3di2ktivxpshwu

10 August 2017

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1 reference

Fatcat

https://api.fatcat.wiki/v0/release/5spfbg2j3nfy3di2ktivxpshwu

24 November 2022

mapped directly with Wikidata item

1 reference

10 August 2017

1 reference