Regulation of angiogenesis by hypoxia and hypoxia-inducible factors (Q36659549)

15 August 2017

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title

Regulation of angiogenesis by hypoxia and hypoxia-inducible factors (English)

1 reference

15 August 2017

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Michele M Hickey

1

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PubMed ID

17118268

15 August 2017

M Celeste Simon

series ordinal

2

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PubMed ID

17118268

15 August 2017

language of work or name

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1 January 2006

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Current Topics in Developmental Biology

15 August 2017

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15 August 2017

76

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15 August 2017

217-257

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Genetic evidence for a tumor suppressor role of HIF-2alpha.

15 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Multilineage embryonic hematopoiesis requires hypoxic ARNT activity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Bacteriolytic therapy can generate a potent immune response against experimental tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

An essential role for p300/CBP in the cellular response to hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Isolation of putative progenitor endothelial cells for angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Expression of HIF-2alpha/EPAS1 in hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Regulation of endothelial matrix metalloproteinase-2 by hypoxia/reoxygenation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain

1 reference

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7 January 2021

Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria

1 reference

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7 January 2021

Macrophages promote angiogenesis in human breast tumour spheroids in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The hypoxic response of tumors is dependent on their microenvironment.

1 reference

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7 January 2021

The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase. Evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning

1 reference

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7 January 2021

Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis

1 reference

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7 January 2021

Activity of hypoxia-inducible factor 2alpha is regulated by association with the NF-kappaB essential modulator

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The hypoxia-inducible factor and tumor progression along the angiogenic pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

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7 January 2021

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

1 reference

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7 January 2021

Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies.

1 reference

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7 January 2021

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)

1 reference

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7 January 2021

Mechanisms of angiogenesis and arteriogenesis

1 reference

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7 January 2021

Angiogenesis in health and disease

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7 January 2021

Angiogenesis in life, disease and medicine

1 reference

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7 January 2021

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Hypoxia is an inducer of vasodilator agents in peritoneal macrophages of cirrhotic patients

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Molecular mechanisms of blood vessel growth

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

HIF-1alpha is essential for myeloid cell-mediated inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Control of cell lineage-specific development and transcription by bHLH-PAS proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Remembrance of things PAS: regulation of development by bHLH-PAS proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Expression of the angiopoietins and their receptor Tie2 in human renal clear cell carcinomas; regulation by the von Hippel-Lindau gene and hypoxia.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Targeting gene expression to hypoxic tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Oncogenes in tumor metabolism, tumorigenesis, and apoptosis

1 reference

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7 January 2021

Combination bacteriolytic therapy for the treatment of experimental tumors

1 reference

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7 January 2021

Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Gastrulation and angiogenesis, not endothelial specification, is sensitive to partial deficiency in vascular endothelial growth factor-a in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Coexpression of endothelial PAS protein 1 with essential angiogenic factors suggests its involvement in human vascular development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Vascular endothelial growth factor: molecular and biological aspects

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The role of vascular endothelial growth factor in angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Angiogenesis as a therapeutic target

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Tumor angiogenesis: therapeutic implications

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Hypoxia-Inducible Factor-1 (HIF-1) Up-Regulates Adrenomedullin Expression in Human Tumor Cell Lines during Oxygen Deprivation: A Possible Promotion Mechanism of Carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

JunD reduces tumor angiogenesis by protecting cells from oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival

1 reference

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7 January 2021

Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of hypoxic preconditioning.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The macrophage - a novel system to deliver gene therapy to pathological hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Neuroprotection by hypoxic preconditioning: HIF-1 and erythropoietin protect from retinal degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The PAS superfamily: sensors of environmental and developmental signals

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Hypoxia requires notch signaling to maintain the undifferentiated cell state

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

A non-hypoxic, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

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https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Hypoxia--a key regulatory factor in tumour growth

1 reference

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7 January 2021

Phase I study of recombinant human endostatin in patients with advanced solid tumors

1 reference

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7 January 2021

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

VEGF-Trap: a VEGF blocker with potent antitumor effects

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Haemangioblast commitment is initiated in the primitive streak of the mouse embryo

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer

1 reference

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7 January 2021

Tumour suppression by the human von Hippel-Lindau gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Molecular regulation of vessel maturation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappa B activation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Molecular basis of the VHL hereditary cancer syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

A common precursor for primitive erythropoiesis and definitive haematopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The mammalian basic helix-loop-helix/PAS family of transcriptional regulators

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Endothelial progenitor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Hypoxia and hypoxia-inducible factor modulated gene expression in brain: involvement in neuroprotection and cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

ARNT-deficient mice and placental differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Suppression of tumor growth through disruption of hypoxia-inducible transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Identification of the von Hippel-Lindau disease tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Early expression of angiogenesis factors in acute myocardial ischemia and infarction

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Tumor-associated macrophages in breast cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Role of the C-terminal alpha-helical domain of the von Hippel-Lindau protein in its E3 ubiquitin ligase activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

PR39, a peptide regulator of angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Oxygen, genes, and development: an analysis of the role of hypoxic gene regulation during murine vascular development.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Tumour-educated macrophages promote tumour progression and metastasis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Hypoxia affects mesoderm and enhances hemangioblast specification during early development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Origin of endothelial progenitors in human postnatal bone marrow

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Mechanisms of angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Signal transduction of ischemic preconditioning

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

HIF-1 and tumor progression: pathophysiology and therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Targeting HIF-1 for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Intramyocardial injection of naked DNA encoding HIF-1alpha/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Angiogenesis: where do we stand now?

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Gene transfer of antisense hypoxia inducible factor-1 alpha enhances the therapeutic efficacy of cancer immunotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Overexpression of von Hippel-Lindau tumor suppressor protein and antisense HIF-1alpha eradicates gliomas

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

pVHL function is essential for endothelial extracellular matrix deposition.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Defective brain development in mice lacking the Hif-1alpha gene in neural cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Endothelial progenitor cells: characterization and role in vascular biology

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Purification and characterization of hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Tumor necrosis factor-alpha causes accumulation of a ubiquitinated form of hypoxia inducible factor-1alpha through a nuclear factor-kappaB-dependent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

Induction of the Plasminogen Activator Inhibitor-1 Gene Expression by Mild Hypoxia Via a Hypoxia Response Element Binding the Hypoxia-Inducible Factor-1 in Rat Hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976007-0

7 January 2021

10.1016/S0070-2153(06)76007-0

Identifiers

DOI

1 reference

15 August 2017

1 reference

PubMed ID

17118268