Alzheimer's disease and the amyloid cascade hypothesis: a critical review (Q35855587)

10 August 2017

Alzheimer's disease and the amyloid cascade hypothesis: a critical review (English)

1 reference

10 August 2017

0 references

Christiane Reitz

1

1 reference

10 August 2017

17 March 2012

1 reference

International journal of Alzheimer's disease

10 August 2017

1 reference

10 August 2017

2012

1 reference

10 August 2017

369808

1 reference

Creative Commons Attribution 3.0 Unported

10 August 2017

start time

1 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

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Treating transgenic Alzheimer mice with a β-secretase inhibitor, what have we learned?

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Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex

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Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study

11 July 2018

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11 July 2018

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Genome-wide analysis of genetic loci associated with Alzheimer disease

11 July 2018

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Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014.

11 July 2018

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Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial

11 July 2018

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A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

11 July 2018

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Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

11 July 2018

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11 July 2018

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11 July 2018

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Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study.

11 July 2018

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Secretase inhibitors and modulators for Alzheimer's disease treatment

11 July 2018

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Long-term follow-up of patients immunized with AN1792: reduced functional decline in antibody responders

11 July 2018

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Development of AFFITOPE vaccines for Alzheimer's disease (AD)--from concept to clinical testing

11 July 2018

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CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.

11 July 2018

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Anti-amyloid-beta immunotherapy in Alzheimer's disease: relevance of transgenic mouse studies to clinical trials.

11 July 2018

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NAP and D-SAL: neuroprotection against the beta amyloid peptide (1-42)

11 July 2018

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Conformational diversity of wild-type Tau fibrils specified by templated conformation change

11 July 2018

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Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine.

11 July 2018

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Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau

11 July 2018

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Cell signaling pathways and iron chelation in the neurorestorative activity of green tea polyphenols: special reference to epigallocatechin gallate (EGCG).

11 July 2018

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Neurofibrillary degeneration in Alzheimer's disease: from molecular mechanisms to identification of drug targets

11 July 2018

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The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease

11 July 2018

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Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

11 July 2018

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PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease

11 July 2018

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Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

11 July 2018

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11 July 2018

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Association between SORL1 and Alzheimer's disease in a genome-wide study

11 July 2018

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Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways

11 July 2018

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Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice

11 July 2018

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Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

11 July 2018

1 reference

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The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort

11 July 2018

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The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

11 July 2018

1 reference

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Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

11 July 2018

1 reference

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Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

11 July 2018

1 reference

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Plaques and tangles and the pathogenesis of Alzheimer's disease.

11 July 2018

1 reference

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Expression of normal sequence pathogenic proteins for neurodegenerative disease contributes to disease risk: 'permissive templating' as a general mechanism underlying neurodegeneration

11 July 2018

1 reference

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Tau suppression in a neurodegenerative mouse model improves memory function

11 July 2018

1 reference

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Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

11 July 2018

1 reference

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Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

11 July 2018

1 reference

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Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Looking for the link between plaques and tangles

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Interactions of Amyloidogenic Proteins

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Alzheimer's disease-do tauists and baptists finally shake hands?

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Immunoreactive changes resulting from dopaminergic denervation of the dentate gyrus of the rat hippocampal formation.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

The molecular pathology of Alzheimer's disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Demonstration of Amyloid Deposits and Neurofibrillary Changes in Whole Brain Sections

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Alzheimer's disease: the amyloid cascade hypothesis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

alpha B-crystallin is present in reactive glia in Creutzfeldt-Jakob disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

The role of amyloid beta-protein in Alzheimer's disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Can lithium or valproate untie tangles in Alzheimer's disease?

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Hope in Alzheimer's fight emerges from unexpected places.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Emerging and potential therapies for Alzheimer's disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Site-specific UBITh amyloid-beta vaccine for immunotherapy of Alzheimer's disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

A Phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Radioiodinated clioquinol as a biomarker for beta-amyloid: Zn complexes in Alzheimer's disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Interaction of Alzheimer's disease amyloid beta peptide fragment 25-35 with tau protein, and with a tau peptide containing the microtubule binding domain.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Application of the National Institute on Aging (NIA)-Reagan Institute criteria for the neuropathological diagnosis of Alzheimer disease.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

The spatial patterns of plaques and tangles in Alzheimer's disease do not support the 'cascade hypothesis'.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

Amyloid P component and other acute-phase proteins associated with cerebellar A beta-deposits in Alzheimer's disease.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3313573

2011 Alzheimer's disease facts and figures

24 September 2018

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https://api.crossref.org/works/10.1155%2F2012%2F369808

The potential of hematopoietic growth factors for treatment of Alzheimer's disease: a mini-review

21 January 2018

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https://api.crossref.org/works/10.1155%2F2012%2F369808

Increased numbers of beta APP-immunoreactive neurones in the entorhinal cortex after head injury

21 January 2018

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12 December 2020

About a peculiar disease of the cerebral cortex. By Alois Alzheimer, 1907 (Translated by L. Jarvik and H. Greenson)

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12 December 2020

Beta-amyloid precursor protein (beta APP) as a marker for axonal injury after head injury

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12 December 2020

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

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12 December 2020

Identifiers

DOI

10.1155/2012/369808

1 reference

10 August 2017

1 reference

10 August 2017

1 reference

PMCID

3313573