Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment (Q35862613)

10 August 2017

Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment (English)

1 reference

Corrigendum: Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment

10 August 2017

corrigendum / erratum

0 references

author

Dun Li

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26009011%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Matthias Dobbelstein

8

1 reference

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12 June 2020

author name string

E M Alexandrova

1

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12 June 2020

A R Yallowitz

2

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12 June 2020

S Xu

4

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12 June 2020

R Schulz

5

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12 June 2020

D A Proia

6

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12 June 2020

G Lozano

7

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12 June 2020

U M Moll

9

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12 June 2020

language of work or name

English

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publication date

25 May 2015

1 reference

10 August 2017

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12 June 2020

volume

523

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12 June 2020

issue

7560

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12 June 2020

page(s)

352-356

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UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib

12 June 2020

cites work

1 reference

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Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling

11 July 2018

1 reference

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Mutant p53 in cancer: new functions and therapeutic opportunities

11 July 2018

1 reference

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Drugging the p53 pathway: understanding the route to clinical efficacy

11 July 2018

1 reference

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Targeting tumour-supportive cellular machineries in anticancer drug development

11 July 2018

1 reference

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Ganetespib and HSP90: translating preclinical hypotheses into clinical promise

11 July 2018

1 reference

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Histone deacetylase inhibitors: an overview of the clinical studies in solid tumors

11 July 2018

1 reference

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A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer

11 July 2018

1 reference

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Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

Geldanamycin and its derivatives as Hsp90 inhibitors

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

Multiple stress signals activate mutant p53 in vivo

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

Targeting the dynamic HSP90 complex in cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

When mutants gain new powers: news from the mutant p53 field.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

Restoration of p53 function leads to tumour regression in vivo

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

HSP90 and the chaperoning of cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

Tumor spectrum analysis in p53-mutant mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506213

Molecular basis of the Li-Fraumeni syndrome: an update from the French LFS families

24 September 2018

1 reference

12 December 2020

Drastic effect of germline TP53 missense mutations in Li-Fraumeni patients

1 reference

12 December 2020

Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumors

1 reference

12 December 2020

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

12 December 2020

Genetic background alters the spectrum of tumors that develop in p53-deficient mice

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE14430

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NATURE14430

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26009011%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

12 June 2020

0 references

1 reference

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12 June 2020

PubMed publication ID

26009011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26009011%20AND%20SRC:MED&resulttype=core&format=json