PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function (Q35867950)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22331464%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

title

PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function (English)

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22 January 2020

3

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22 January 2020

Yan-ying Huo

5

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22 January 2020

10

Ah-Ng Tony Kong

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22 January 2020

author name string

Jianglin Ma

1

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22 January 2020

Hong Cai

2

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22 January 2020

Bijan Sobhian

4

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22 January 2020

Allen Alcivar

6

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22 January 2020

Monal Mehta

7

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22 January 2020

Ka Lung Cheung

8

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22 January 2020

Shridar Ganesan

9

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22 January 2020

Donna D Zhang

11

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22 January 2020

Bing Xia

12

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22 January 2020

language of work or name

English

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publication date

13 February 2012

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Molecular and Cellular Biology

22 January 2020

published in

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22 January 2020

volume

32

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22 January 2020

issue

8

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22 January 2020

page(s)

1506-1517

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Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer

22 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318596

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution

11 July 2018

1 reference

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A PALB2 mutation associated with high risk of breast cancer

11 July 2018

1 reference

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PALB2/FANCN: recombining cancer and Fanconi anemia

11 July 2018

1 reference

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Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

11 July 2018

1 reference

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Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

11 July 2018

1 reference

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An internal ribosomal entry site mediates redox-sensitive translation of Nrf2.

11 July 2018

1 reference

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Structural basis for recruitment of BRCA2 by PALB2

11 July 2018

1 reference

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PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.

11 July 2018

1 reference

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PALB2 is an integral component of the BRCA complex required for homologous recombination repair

11 July 2018

1 reference

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NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

11 July 2018

1 reference

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PALB2 links BRCA1 and BRCA2 in the DNA-damage response

11 July 2018

1 reference

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Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

11 July 2018

1 reference

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Association of common PALB2 polymorphisms with breast cancer risk: a case-control study

11 July 2018

1 reference

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Molecular mechanisms of Nrf2-mediated antioxidant response

11 July 2018

1 reference

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Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

11 July 2018

1 reference

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Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

11 July 2018

1 reference

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Promoter hypermethylation of the PALB2 susceptibility gene in inherited and sporadic breast and ovarian cancer

11 July 2018

1 reference

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The genomic landscapes of human breast and colorectal cancers

11 July 2018

1 reference

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A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318596

Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318596

Analysis of PALB2/FANCN-associated breast cancer families

11 July 2018

1 reference

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Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.

11 July 2018

1 reference

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Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318596

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318596

Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318596

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318596

Free radicals and antioxidants in normal physiological functions and human disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318596

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

11 July 2018

1 reference

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Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

11 July 2018

1 reference

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Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

11 July 2018

1 reference

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Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

11 July 2018

1 reference

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BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318596

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318596

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318596

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318596

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318596

Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318596

Fanconi anemia proteins and endogenous stresses

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318596

A recurrent mutation in PALB2 in Finnish cancer families.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318596

Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318596

PALB2 mutations in European familial pancreatic cancer families

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22331464

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.06271-11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22331464%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22331464%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

PubMed publication ID

22331464

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22331464%20AND%20SRC:MED&resulttype=core&format=json