APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1. (Q35870045)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22122463%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1 (English)

1 reference

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17 January 2020

3

1 reference

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17 January 2020

2

Millie M Georgiadis

1 reference

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17 January 2020

author name string

Mark R Kelley

series ordinal

1

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17 January 2020

publication date

1 January 2012

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Current molecular pharmacology

17 January 2020

published in

1 reference

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17 January 2020

volume

5

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17 January 2020

issue

1

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17 January 2020

page(s)

36-53

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Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth

17 January 2020

cites work

1 reference

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Inhibition of APE1/Ref-1 redox activity with APX3330 blocks retinal angiogenesis in vitro and in vivo

27 July 2018

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Vasodilatation in the rat dorsal hindpaw induced by activation of sensory neurons is reduced by paclitaxel

27 July 2018

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Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1.

27 July 2018

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Inhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis

27 July 2018

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Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response

27 July 2018

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Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions

27 July 2018

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HIF-1 attenuates Ref-1 expression in endothelial cells: reversal by siRNA and inhibition of geranylgeranylation

27 July 2018

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Small-molecule inhibitors of proteins involved in base excision repair potentiate the anti-tumorigenic effect of existing chemotherapeutics and irradiation

27 July 2018

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Apurinic/apyrimidinic endonuclease 1 alters estrogen receptor activity and estrogen-responsive gene expression

27 July 2018

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Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism

27 July 2018

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Oxidation status of human OGG1-S326C polymorphic variant determines cellular DNA repair capacity.

27 July 2018

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APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

27 July 2018

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Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells.

27 July 2018

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Radiation-induced HIF-1alpha cell survival pathway is inhibited by soy isoflavones in prostate cancer cells

27 July 2018

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The many functions of APE1/Ref-1: not only a DNA repair enzyme

27 July 2018

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Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells

27 July 2018

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Apurinic/apyrimidinic endonuclease/redox effector factor-1(APE/Ref-1): a unique target for the prevention and treatment of human melanoma

27 July 2018

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Going ape as an approach to cancer therapeutics

27 July 2018

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Implications of apurinic/apyrimidinic endonuclease in reactive oxygen signaling response after cisplatin treatment of dorsal root ganglion neurons

27 July 2018

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Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration

27 July 2018

1 reference

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Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1

27 July 2018

1 reference

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DNA repair proteins as molecular targets for cancer therapeutics

27 July 2018

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Targeting base excision repair for chemosensitization

27 July 2018

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Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability.

27 July 2018

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Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage

27 July 2018

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Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth

27 July 2018

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Novel mechanism whereby nuclear factor kappaB mediates DNA damage repair through regulation of O(6)-methylguanine-DNA-methyltransferase

27 July 2018

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Targeting DNA repair as a promising approach in cancer therapy

27 July 2018

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Subcellular localization of APE1/Ref-1 in human hepatocellular carcinoma: possible prognostic significance.

27 July 2018

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Regulation of DNA repair in hypoxic cancer cells

27 July 2018

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Experimental study enhancing the chemosensitivity of multiple myeloma to melphalan by using a tissue-specific APE1-silencing RNA expression vector

27 July 2018

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Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins

27 July 2018

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Co-repression of mismatch repair gene expression by hypoxia in cancer cells: role of the Myc/Max network

27 July 2018

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The role of glutathione in the regulation of nucleotide excision repair during oxidative stress.

27 July 2018

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Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide.

27 July 2018

1 reference

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Mechanism of interaction between human 8-oxoguanine-DNA glycosylase and AP endonuclease

27 July 2018

1 reference

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XRCC1 interactions with base excision repair DNA intermediates

27 July 2018

1 reference

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The thioredoxin system in cancer

27 July 2018

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p53 modulation of the DNA damage response

27 July 2018

1 reference

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The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression

27 July 2018

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Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia

27 July 2018

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Efficiency of carcinogenesis with and without a mutator mutation

27 July 2018

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The human apurinic/apyrimidinic endonuclease-1 suppresses activation of poly(adp-ribose) polymerase-1 induced by DNA single strand breaks

27 July 2018

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Bcl2 suppresses DNA repair by enhancing c-Myc transcriptional activity

27 July 2018

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Transcriptional anti-angiogenesis therapy of human pancreatic cancer

27 July 2018

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Alterations in DNA repair gene expression under hypoxia: elucidating the mechanisms of hypoxia-induced genetic instability

27 July 2018

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p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene

27 July 2018

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DNA repair inhibition: a selective tumour targeting strategy.

27 July 2018

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Isolation of a small molecule inhibitor of DNA base excision repair.

27 July 2018

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Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells

27 July 2018

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Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs

27 July 2018

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Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements

27 July 2018

1 reference

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The intracellular localization of APE1/Ref-1: more than a passive phenomenon?

27 July 2018

1 reference

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Tumor suppressor p53 represses transcription of RECQ4 helicase

27 July 2018

1 reference

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AP-1 subunits: quarrel and harmony among siblings

27 July 2018

1 reference

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Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells

27 July 2018

1 reference

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Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides.

27 July 2018

1 reference

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AP endonuclease-independent DNA base excision repair in human cells

27 July 2018

1 reference

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APE1 is the major 3'-phosphoglycolate activity in human cell extracts

27 July 2018

1 reference

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Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition

27 July 2018

1 reference

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Hypoxia inducible factor-1alpha as a cancer drug target

27 July 2018

1 reference

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Tumbling down a different pathway to genetic instability.

27 July 2018

1 reference

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Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene

27 July 2018

1 reference

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Mechanisms of human DNA repair: an update

27 July 2018

1 reference

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The role of p53 in base excision repair following genotoxic stress

27 July 2018

1 reference

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Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death

27 July 2018

1 reference

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Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling

27 July 2018

1 reference

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Decreased Expression of the DNA Mismatch Repair Gene Mlh1 under Hypoxic Stress in Mammalian Cells

27 July 2018

1 reference

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Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer

27 July 2018

1 reference

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Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

27 July 2018

1 reference

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Oxidoreductive modification of two cysteine residues in paired domain by Ref-1 regulates DNA-binding activity of Pax-8

27 July 2018

1 reference

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27 July 2018

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p53 regulation of DNA excision repair pathways

27 July 2018

1 reference

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Histology-specific expression of a DNA repair protein in pediatric rhabdomyosarcomas.

27 July 2018

1 reference

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An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA

27 July 2018

1 reference

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Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter

27 July 2018

1 reference

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Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair

27 July 2018

1 reference

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The major human abasic endonuclease: formation, consequences and repair of abasic lesions in DNA.

27 July 2018

1 reference

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Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin

27 July 2018

1 reference

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Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism

27 July 2018

1 reference

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Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation.

27 July 2018

1 reference

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27 July 2018

Going APE over ref-1.

1 reference

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p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV.

27 July 2018

1 reference

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High-performance affinity beads for identifying drug receptors

27 July 2018

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A novel action of human apurinic/apyrimidinic endonuclease: excision of L-configuration deoxyribonucleoside analogs from the 3' termini of DNA.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Isoprostanes, novel eicosanoids that produce nociception and sensitize rat sensory neurons

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

An 'environment to nucleus' signaling system operates in B lymphocytes: redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

p53-mediated regulation of proliferating cell nuclear antigen expression in cells exposed to ionizing radiation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Human AP endonuclease 1 (HAP1) protein expression in breast cancer correlates with lymph node status and angiogenesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Redox regulation of AP-1: a link between transcription factor signaling and DNA repair.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

A double-strand break within a yeast artificial chromosome (YAC) containing human DNA can result in YAC loss, deletion or cell lethality

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Induction of murine O6-alkylguanine-DNA-alkyltransferase in response to ionising radiation is p53 gene dose dependent

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Characterization of the DNA-binding properties of the early growth response-1 (Egr-1) transcription factor: evidence for modulation by a redox mechanism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Inhibition of AP-1 binding and transcription by gold and selenium involving conserved cysteine residues in Jun and Fos.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Deletions at short direct repeats and base substitutions are characteristic mutations for bleomycin-induced double- and single-strand breaks, respectively, in a human shuttle vector system

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Thioredoxin and glutaredoxin systems

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Design and synthesis of novel quinone inhibitors targeted to the redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (Ape1/ref-1).

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Redox regulation of DNA repair: implications for human health and cancer therapeutic development

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

The Ape-1/Ref-1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: therapeutic implications in tumor angiogenesis.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Loss of VLDL receptor activates retinal vascular endothelial cells and promotes angiogenesis

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Resveratrol, a unique phytoalexin present in red wine, delivers either survival signal or death signal to the ischemic myocardium depending on dose

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Expression of VLDLR in the retina and evolution of subretinal neovascularization in the knockout mouse model's retinal angiomatous proliferation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Cell cycle activation in postmitotic neurons is essential for DNA repair.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

XRCC1 interactions with multiple DNA glycosylases: a model for its recruitment to base excision repair.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

p53: traffic cop at the crossroads of DNA repair and recombination

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Apurinic/apyrimidinic endonuclease 1 regulates endothelial NO production and vascular tone.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Protection of pulmonary epithelial cells from oxidative stress by hMYH adenine glycosylase

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Cell cycle activation linked to neuronal cell death initiated by DNA damage

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

The exonuclease activity of human apurinic/apyrimidinic endonuclease (APE1). Biochemical properties and inhibition by the natural dinucleotide Gp4G.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Redox signaling of angiogenesis

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Prognostic and pathologic significance of quantitative protein expression profiling in human gliomas.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Transcriptional regulation of the p67phox gene: role of AP-1 in concert with myeloid-specific transcription factors

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Nuclear expression of human apurinic/apyrimidinic endonuclease (HAP1/Ref-1) in head-and-neck cancer is associated with resistance to chemoradiotherapy and poor outcome.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Thioredoxin-dependent redox regulation of p53-mediated p21 activation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Identification of redox/repair protein Ref-1 as a potent activator of p53

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

MutS homologs in mammalian cells

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme, APEX nuclease.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Redox regulation of the DNA binding activity in transcription factor PEBP2. The roles of two conserved cysteine residues

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319314

Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers

24 September 2018

1 reference

12 December 2020

Prognostic role of Ape/Ref-1 subcellular expression in stage I-III breast carcinomas

1 reference

12 December 2020

Prognostic significance of Ape1/ref-1 subcellular localization in non-small cell lung carcinomas

1 reference

12 December 2020

Redox factor-1/APE suppresses oxidative stress by inhibiting the rac1 GTPase

1 reference

12 December 2020

Redox regulation of fos and jun DNA-binding activity in vitro

1 reference

12 December 2020

Two different cellular redox systems regulate the DNA-binding activity of the p50 subunit of NF-kappa B in vitro

1 reference

12 December 2020

Biological responses of human apurinic endonuclease to radiation-induced DNA damage

1 reference

12 December 2020

The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer

1 reference

12 December 2020

Nuclear targeted suppression of NF-kappa B activity by the novel quinone derivative E3330

1 reference

12 December 2020

The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress

1 reference

12 December 2020

Redox factor 1 (Ref-1) enhances specific DNA binding of p53 by promoting p53 tetramerization

1 reference

12 December 2020

10.2174/1874467211205010036

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22122463%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22122463%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference