p53: traffic cop at the crossroads of DNA repair and recombination (Q36028209)

11 August 2017

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title

p53: traffic cop at the crossroads of DNA repair and recombination (English)

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11 August 2017

Sagar Sengupta

1

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11 August 2017

Curtis C Harris

series ordinal

2

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11 August 2017

publication date

1 January 2005

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Nature Reviews Molecular Cell Biology

11 August 2017

published in

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11 August 2017

volume

6

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11 August 2017

issue

1

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11 August 2017

page(s)

44-55

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NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

11 August 2017

cites work

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31 March 2020

Surfing the p53 network

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Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression

31 March 2020

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A model for p53-induced apoptosis

31 March 2020

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The p53 tumour suppressor gene

31 March 2020

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p53 mutations in human cancers

31 March 2020

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31 March 2020

p53: puzzle and paradigm

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p53 protein at the hub of cellular DNA damage response pathways through sequence-specific and non-sequence-specific DNA binding

31 March 2020

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p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

31 March 2020

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p53 binds the nuclear matrix in normal cells: binding involves the proline-rich domain of p53 and increases following genotoxic stress

31 March 2020

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p53 is a rate-limiting factor in the repair of higher-order DNA structure

31 March 2020

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Genome maintenance mechanisms for preventing cancer

31 March 2020

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How nucleotide excision repair protects against cancer

31 March 2020

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Repair of abasic sites in DNA.

31 March 2020

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Mechanism and regulation of human non-homologous DNA end-joining

31 March 2020

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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

31 March 2020

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Xeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein

31 March 2020

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Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts

31 March 2020

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p53 modulation of TFIIH-associated nucleotide excision repair activity

31 March 2020

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Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

31 March 2020

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p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene

31 March 2020

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Impaired Regulation of Tumor Suppressor p53 Caused by Mutations in the Xeroderma Pigmentosum DDB2 Gene: Mutual Regulatory Interactions between p48DDB2 and p53

31 March 2020

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Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage

31 March 2020

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In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product

31 March 2020

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UV radiation-induced XPC translocation within chromatin is mediated by damaged-DNA binding protein, DDB2.

31 March 2020

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p53 responsive nucleotide excision repair gene products p48 and XPC, but not p53, localize to sites of UV-irradiation-induced DNA damage, in vivo

31 March 2020

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31 March 2020

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The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

31 March 2020

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p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage

31 March 2020

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p53 and regulation of DNA damage recognition during nucleotide excision repair

31 March 2020

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Human cells compromised for p53 function exhibit defective global and transcription-coupled nucleotide excision repair, whereas cells compromised for pRb function are defective only in global repair

31 March 2020

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Transcription - guarding the genome by sensing DNA damage

31 March 2020

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Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance

31 March 2020

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The p53-regulated cyclin-dependent kinase inhibitor, p21 (cip1, waf1, sdi1), is not required for global genomic and transcription-coupled nucleotide excision repair of UV-induced DNA photoproducts

31 March 2020

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UV wavelength-dependent regulation of transcription-coupled nucleotide excision repair in p53-deficient human cells

31 March 2020

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Activation of p53 or loss of the Cockayne syndrome group B repair protein causes metaphase fragility of human U1, U2, and 5S genes

31 March 2020

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Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo.

31 March 2020

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Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery

31 March 2020

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The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA.

31 March 2020

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The role of p53 in base excision repair following genotoxic stress

31 March 2020

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Role of p53 in sensing oxidative DNA damage in response to reactive oxygen species-generating agents

31 March 2020

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Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses.

31 March 2020

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A role for p53 in base excision repair.

31 March 2020

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Implication of p53 in base excision DNA repair: in vivo evidence

31 March 2020

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Structural and functional involvement of p53 in BER in vitro and in vivo

31 March 2020

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Selenomethionine regulation of p53 by a ref1-dependent redox mechanism

31 March 2020

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Role of DNA mismatch repair defects in the pathogenesis of human cancer

31 March 2020

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ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage

31 March 2020

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Female embryonic lethality in mice nullizygous for both Msh2 and p53

31 March 2020

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p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV.

31 March 2020

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Interactions between p53, hMSH2-hMSH6 and HMG I(Y) on Holliday junctions and bulged bases

31 March 2020

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Association of p53 and MSH2 with recombinative repair complexes during S phase

31 March 2020

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p53 status correlates with the differential expression of the DNA mismatch repair protein MSH2 in non-small cell lung carcinoma

31 March 2020

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Possible association between tumor-suppressor gene mutations and hMSH2/hMLH1 inactivation in alveolar soft part sarcoma

31 March 2020

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Chromosomal instability and p53 inactivation are required for genesis of glioblastoma but not for colorectal cancer in patients with germline mismatch repair gene mutation.

31 March 2020

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Pathways of DNA double-strand break repair during the mammalian cell cycle

31 March 2020

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

31 March 2020

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The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest

31 March 2020

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The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase

31 March 2020

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DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

31 March 2020

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p53 induced by ionizing radiation mediates DNA end-jointing activity, but not apoptosis of thyroid cells

31 March 2020

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Suppression of high-fidelity double-strand break repair in mammalian chromosomes by pifithrin-alpha, a chemical inhibitor of p53.

31 March 2020

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Radioresistant MTp53-expressing rat embryo cell transformants exhibit increased DNA-dsb rejoining during exposure to ionizing radiation

31 March 2020

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A role for p53 in DNA end rejoining by human cell extracts

31 March 2020

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DNA substrate dependence of p53-mediated regulation of double-strand break repair

31 March 2020

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Effect of wild-type, S15D and R175H p53 proteins on DNA end joining in vitro: potential mechanism of DNA double-strand break repair modulation.

31 March 2020

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Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

31 March 2020

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Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

31 March 2020

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A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

31 March 2020

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Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

31 March 2020

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DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

31 March 2020

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Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

31 March 2020

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Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells.

31 March 2020

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A novel function of Rad54 protein. Stabilization of the Rad51 nucleoprotein filament

31 March 2020

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Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination

31 March 2020

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Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation

31 March 2020

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Dissociation of the recombination control and the sequence-specific transactivation function of P53

31 March 2020

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Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein

31 March 2020

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Homologous recombination induced by replication inhibition, is stimulated by expression of mutant p53.

31 March 2020

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Inactivation of p53 results in high rates of homologous recombination

31 March 2020

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Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint.

31 March 2020

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p53 and recombination intermediates: role of tetramerization at DNA junctions in complex formation and exonucleolytic degradation

31 March 2020

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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

31 March 2020

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BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination

31 March 2020

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Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control

31 March 2020

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p53 mutated in the transactivation domain retains regulatory functions in homology-directed double-strand break repair

31 March 2020

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p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction

31 March 2020

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Interaction of p53 with the human Rad51 protein

31 March 2020

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Role of heteroduplex joints in the functional interactions between human Rad51 and wild-type p53.

31 March 2020

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P53 inhibits strand exchange and replication fork regression promoted by human Rad51.

31 March 2020

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Homologous recombination in extrachromosomal plasmid substrates is not suppressed by p53.

31 March 2020

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p53 protects from replication-associated DNA double-strand breaks in mammalian cells

31 March 2020

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RecQ helicases: caretakers of the genome

31 March 2020

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The Bloom's syndrome helicase suppresses crossing over during homologous recombination

31 March 2020

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Homologous recombination resolution defect in werner syndrome

31 March 2020

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Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53.

31 March 2020

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The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control

31 March 2020

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p53-mediated apoptosis is attenuated in Werner syndrome cells

31 March 2020

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Functional interaction of p53 and BLM DNA helicase in apoptosis

31 March 2020

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Physical and functional interaction between p53 and the Werner's syndrome protein

31 March 2020

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The processing of Holliday junctions by BLM and WRN helicases is regulated by p53

31 March 2020

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The Werner syndrome protein contributes to induction of p53 by DNA damage

31 March 2020

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p53 Modulates the exonuclease activity of Werner syndrome protein

31 March 2020

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ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

31 March 2020

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BLM, the Bloom's syndrome protein, varies during the cell cycle in its amount, distribution, and co-localization with other nuclear proteins

31 March 2020

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Nuclear structure in normal and Bloom syndrome cells

31 March 2020

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DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma

31 March 2020

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Elevated recombination in immortal human cells is mediated by HsRAD51 recombinase

31 March 2020

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A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

31 March 2020

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Essential role of limiting telomeres in the pathogenesis of Werner syndrome

31 March 2020

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Abnormal centrosome amplification in the absence of p53.

31 March 2020

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A p53-dependent mouse spindle checkpoint

31 March 2020

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31 March 2020

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Cell cycle checkpoint signaling through the ATM and ATR kinases

31 March 2020

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Chk1 and Chk2 kinases in checkpoint control and cancer

31 March 2020

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Megabase chromatin domains involved in DNA double-strand breaks in vivo

31 March 2020

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DNA damage tumor suppressor genes and genomic instability

31 March 2020

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Questioning the role of checkpoint kinase 2 in the p53 DNA damage response

31 March 2020

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

31 March 2020

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Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

31 March 2020

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Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest

31 March 2020

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Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

31 March 2020

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A role for ATR in the DNA damage-induced phosphorylation of p53

31 March 2020

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Cancer. p53, guardian of the genome

31 March 2020

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p53 in the cytoplasm: a question of overkill?

31 March 2020

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In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomes

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM1546

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Dimensions Publication ID

11 August 2017

1022736067

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