TCR zeta-chain downregulation: curtailing an excessive inflammatory immune response (Q35877202)

10 August 2017

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title

TCR zeta-chain downregulation: curtailing an excessive inflammatory immune response (English)

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10 August 2017

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Michal Baniyash

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10 August 2017

1 September 2004

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Nature Reviews Immunology

10 August 2017

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10 August 2017

4

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10 August 2017

675-687

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10 August 2017

9

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The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation

10 August 2017

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Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

21 January 2018

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Positive and negative regulation of T-cell activation by adaptor proteins

21 January 2018

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Initiation of TCR signaling: regulation within CD3 dimers

21 January 2018

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T-cell-antigen recognition and the immunological synapse

21 January 2018

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Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation

21 January 2018

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CTLA-4 and tolerance: the biochemical point of view

21 January 2018

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Negative regulation of TCR signaling and T-cell activation by selective protein degradation

21 January 2018

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Identification of the components of the murine T cell antigen receptor complex

21 January 2018

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Co-association of CD3 zeta with a receptor (CD16) for IgG Fc on human natural killer cells.

21 January 2018

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Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.

21 January 2018

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The formation and functions of the 21- and 23-kDa tyrosine-phosphorylated TCR zeta subunits

21 January 2018

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Tyrosine-phosphorylated T cell receptor ζ chain associates with the actin cytoskeleton upon Activation of mature T lymphocytes

21 January 2018

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Regulation of constitutive TCR internalization by the zeta-chain.

21 January 2018

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Signals from lymphocytes in colon cancer

21 January 2018

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Down-regulation of the CD3-zeta chain in sentinel node biopsies from breast cancer patients.

21 January 2018

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Defective expression of the T-cell receptor-CD3 zeta chain in T-cell acute lymphoblastic leukaemia

21 January 2018

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Central role of leukemia-derived factors in the development of leukemia-associated immune dysfunction

21 January 2018

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Modulation of TcR/CD3-zeta chain expression by a circulating factor derived from ovarian cancer patients

21 January 2018

1 reference

Immune cell signaling in lupus

21 January 2018

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A potential role for protein tyrosine kinase p56(lck) in rheumatoid arthritis synovial fluid T lymphocyte hyporesponsiveness.

21 January 2018

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Studies of T-cell activation in chronic inflammation

21 January 2018

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Rewiring the T-cell: signaling defects and novel prospects for the treatment of SLE

21 January 2018

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Sustained exposure to bacterial antigen induces interferon-γ-dependent T cell receptor ζ down-regulation and impaired T cell function

21 January 2018

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Derangement of immune responses by myeloid suppressor cells

21 January 2018

1 reference

Antitumor vaccines: is it possible to prevent a tumor?

21 January 2018

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MUC1 and the immunobiology of cancer

21 January 2018

1 reference

Nasopharyngeal carcinoma and the EBV-specific T cell response: prospects for immunotherapy

21 January 2018

1 reference

Peptide-based immunotherapy of systemic lupus erythematosus

21 January 2018

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Toll-like receptors and T-helper-1/T-helper-2 responses

21 January 2018

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Inflammation and Cancer II. Role of chronic inflammation and cytokine gene polymorphisms in the pathogenesis of gastrointestinal malignancy.

21 January 2018

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Possible role of ovarian epithelial inflammation in ovarian cancer

21 January 2018

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Epidemiology of inflammation and prostate cancer.

21 January 2018

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Chronic pancreatitis and pancreatic cancer

21 January 2018

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Exploring the reciprocal relationship between immunity and inflammation in chronic inflammatory arthritis.

21 January 2018

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Why does chronic inflammatory joint disease persist?

21 January 2018

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Chemical basis of inflammation-induced carcinogenesis

21 January 2018

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Chronic inflammation as inductor of pro-cancer microenvironment: pathogenesis of dysregulated feedback control

21 January 2018

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Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 zeta chain of T-cell receptor complex and antigen-specific T-cell responses

21 January 2018

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Macrophage effector mechanisms in melanoma in an experimental study

21 January 2018

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L-arginine consumption by macrophages modulates the expression of CD3 zeta chain in T lymphocytes

21 January 2018

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Prolonged exposure of T cells to TNF down-regulates TCR zeta and expression of the TCR/CD3 complex at the cell surface.

21 January 2018

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Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

21 January 2018

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Distinct monoubiquitin signals in receptor endocytosis

21 January 2018

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TCR zeta mRNA with an alternatively spliced 3'-untranslated region detected in systemic lupus erythematosus patients leads to the down-regulation of TCR zeta and TCR/CD3 complex

21 January 2018

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Shedding light on immunotherapy for cancer

21 January 2018

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Regulation of myeloid development and function by colony stimulating factors.

21 January 2018

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A push-pull approach to maximize vaccine efficacy: abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte/macrophage colony-stimulating factor and CD40L

21 January 2018

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Clinical research helps elucidate the role of tumor necrosis factor-αin the pathogenesis of T1-mediated immune disorders: use of targeted immunotherapeutics as pathogenic probes

21 January 2018

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CD30+ T-cell lymphoma in a patient with psoriasis treated with ciclosporin and infliximab

21 January 2018

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Randomized, double-blind trial of anti-interferon-gamma antibodies in rheumatoid arthritis.

21 January 2018

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Classical and slow-binding inhibitors of human type II arginase

21 January 2018

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Blocking NO synthesis: how, where and why?

21 January 2018

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Reduced T-cell receptor CD3zeta-chain protein and sustained CD3epsilon expression at the site of mycobacterial infection

21 January 2018

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Human immunodeficiency virus-specific circulating CD8 T lymphocytes have down-modulated CD3zeta and CD28, key signaling molecules for T-cell activation

21 January 2018

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Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism.

21 January 2018

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Arginine metabolism: nitric oxide and beyond

21 January 2018

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Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

21 January 2018

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Adapters in lymphocyte signaling

21 January 2018

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Coordination of T cell activation and migration through formation of the immunological synapse.

31 March 2020

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Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation

31 March 2020

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Expression of the T cell antigen receptor zeta chain following activation is controlled at distinct checkpoints. Implications for cell surface receptor down-modulation and re-expression

31 March 2020

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T cell activation determined by T cell receptor number and tunable thresholds.

31 March 2020

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Molecular cloning of the zeta chain of the T cell antigen receptor.

31 March 2020

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Cell-surface-expressed T-cell antigen-receptor zeta chain is associated with the cytoskeleton

31 March 2020

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The T cell antigen receptor: insights into organelle biology

31 March 2020

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Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules

31 March 2020

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Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice

31 March 2020

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Alterations in the signal-transducing molecules of T cells and NK cells in colorectal tumor-infiltrating, gut mucosal and peripheral lymphocytes: correlation with the stage of the disease

31 March 2020

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Expression of zeta in T cells prior to interleukin-2 therapy as a predictor of response and survival in patients with ovarian carcinoma

31 March 2020

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Peripheral T lymphocytes from women with breast cancer exhibit abnormal protein expression of several signaling molecules

31 March 2020

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Impaired expression and function of signal-transducing zeta chains in peripheral T cells and natural killer cells in patients with prostate cancer.

31 March 2020

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Correlation between disease activity and T-cell CD3 zeta chain expression in a B-cell lymphoma

31 March 2020

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Expression of signal-transducing zeta chain in peripheral blood T cells and natural killer cells in patients with Hodgkin's disease in different phases of the disease

31 March 2020

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Immunological escape mechanisms in pancreatic carcinoma

31 March 2020

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Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain

31 March 2020

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HIV infection--induced posttranslational modification of T cell signaling molecules associated with disease progression

31 March 2020

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PSA markers in prostate cancer detection

31 March 2020

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Novel approaches in the treatment of lupus nephritis

31 March 2020

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Evolutionary clues to the functions of the Toll-like family as surveillance receptors

31 March 2020

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Chapter 4: Genital tract infections, cervical inflammation, and antioxidant nutrients--assessing their roles as human papillomavirus cofactors.

31 March 2020

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Lymphocytes, cytokines, inflammation, and immune trafficking

31 March 2020

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Chronic infection and coronary artery disease

31 March 2020

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Prevalence of T cell receptor zeta chain deficiency in systemic lupus erythematosus

31 March 2020

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Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing zeta molecules and inhibits tumor-specific T cell-and natural killer cell-mediated cytotoxicity

31 March 2020

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Diminished levels of T cell receptor zeta chains in peripheral blood T lymphocytes from patients with systemic lupus erythematosus

31 March 2020

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Activation of the Ets transcription factor Elf-1 requires phosphorylation and glycosylation: defective expression of activated Elf-1 is involved in the decreased TCR zeta chain gene expression in patients with systemic lupus erythematosus

31 March 2020

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Immunotherapy of malignant melanoma

31 March 2020

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Prostate-specific antigen vaccines for prostate cancer

31 March 2020

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Immune response manipulation: recombinant immunoreceptors endow T-cells with predefined specificity

31 March 2020

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Role of immature myeloid Gr-1+ cells in the development of antitumor immunity

31 March 2020

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The decreased expression of CD3 ζ chains in cancer patients is not reversed BY IL-2 Administration

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1434

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10 August 2017

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PubMed ID

15343367