Eradication of B-ALL using chimeric antigen receptor-expressing T cells targeting the TSLPR oncoprotein. (Q35904943)

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16 February 2020

title

Eradication of B-ALL using chimeric antigen receptor-expressing T cells targeting the TSLPR oncoprotein (English)

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9

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David T Teachey

12

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16 February 2020

Mads Daugaard

15

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17

Stephan A Grupp

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Terry J Fry

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Shannon Maude

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5

Sarah K Tasian

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16 February 2020

author name string

Haiying Qin

1

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16 February 2020

Monica Cho

2

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16 February 2020

Waleed Haso

3

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16 February 2020

Ling Zhang

4

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16 February 2020

Htoo Zarni Oo

6

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16 February 2020

Gian Luca Negri

7

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Yongshun Lin

8

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Barbara S Mallon

10

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16 February 2020

David M Barrett

13

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16 February 2020

Rimas J Orentas

14

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16 February 2020

Poul H B Sorensen

16

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16 February 2020

language of work or name

English

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publication date

3 June 2015

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16 February 2020

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16 February 2020

volume

126

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issue

5

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16 February 2020

page(s)

629-639

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Thymic stromal lymphopoietin and cancer

16 February 2020

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11 July 2018

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Outcomes of children with BCR-ABL1–like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease

11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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Relapsed childhood acute lymphoblastic leukaemia

11 July 2018

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Interleukin 7 and thymic stromal lymphopoietin: from immunity to leukemia

11 July 2018

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Acute lymphoblastic leukemia in adults: encouraging developments on the way to higher cure rates

11 July 2018

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Chimeric antigen receptor-modified T cells for acute lymphoid leukemia

11 July 2018

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Acute lymphoblastic leukaemia

11 July 2018

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Children's Oncology Group's 2013 blueprint for research: acute lymphoblastic leukemia

11 July 2018

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Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia

11 July 2018

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Where do we stand in the treatment of relapsed acute lymphoblastic leukemia?

11 July 2018

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Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project

11 July 2018

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Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia

11 July 2018

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Differences in signaling through the B-cell leukemia oncoprotein CRLF2 in response to TSLP and through mutant JAK2.

11 July 2018

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Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia

11 July 2018

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Adoptive immunotherapy for cancer: harnessing the T cell response

11 July 2018

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Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study

11 July 2018

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B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

11 July 2018

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Understanding the biology of CRLF2-overexpressing acute lymphoblastic leukemia

11 July 2018

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11 July 2018

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Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias

11 July 2018

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Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia

11 July 2018

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Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia

11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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Thymic stromal lymphopoietin in normal and pathogenic T cell development and function

11 July 2018

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The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL

11 July 2018

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11 July 2018

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Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia.

11 July 2018

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Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia

11 July 2018

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Effects of an anti-TSLP antibody on allergen-induced asthmatic responses

24 September 2018

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IKZF1 and CRLF2 gene alterations correlate with poor prognosis in Japanese BCR-ABL1-negative high-risk B-cell precursor acute lymphoblastic leukemia.

24 September 2018

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IGH@ translocations, CRLF2 deregulation, and microdeletions in adolescents and adults with acute lymphoblastic leukemia

24 September 2018

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Treatment outcome of CRLF2-rearranged childhood acute lymphoblastic leukaemia: a comparative analysis of the AIEOP-BFM and UK NCRI-CCLG study groups

24 September 2018

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Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia.

24 September 2018

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Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo

24 September 2018

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Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol

24 September 2018

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12 December 2020

Demographic, clinical, and outcome features of children with acute lymphoblastic leukemia and CRLF2 deregulation: results from the MRC ALL97 clinical trial

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Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia

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The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens

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12 December 2020

10.1182/BLOOD-2014-11-612903

Identifiers

DOI

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16 February 2020

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16 February 2020

PubMed publication ID

26041741

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