Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of β-lactams (Q35908084)

11 August 2017

3 references

22 June 2019

7 November 2019

11 September 2020

Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of β-lactams (English)

1 reference

11 August 2017

0 references

1 reference

7 November 2019

1 reference

11 September 2020

1 reference

1 reference

Joao Gonçalves-Pereira

series ordinal

1

1 reference

11 August 2017

Pedro Póvoa

series ordinal

2

1 reference

11 August 2017

language of work or name

1 reference

13 September 2011

4 references

11 August 2017

22 June 2019

7 November 2019

11 September 2020

4 references

11 August 2017

22 June 2019

7 November 2019

11 September 2020

15

1 reference

11 August 2017

5

1 reference

11 August 2017

R206

1 reference

Creative Commons Attribution 2.0 Generic

11 August 2017

3 references

22 June 2019

7 November 2019

https://scigraph.springernature.com/pub.10.1186/cc10441

11 September 2020

0 references

0 references

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Principles of antibacterial dosing in continuous renal replacement therapy

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Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock

27 July 2018

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Prospective monitoring of cefepime in intensive care unit adult patients

27 July 2018

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Population pharmacokinetics of ceftazidime in intensive care unit patients: influence of glomerular filtration rate, mechanical ventilation, and reason for admission.

27 July 2018

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A systematic review on clinical benefits of continuous administration of beta-lactam antibiotics

27 July 2018

1 reference

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Pharmacodynamic optimization of beta-lactams in the patient care setting

27 July 2018

1 reference

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Application of basic pharmacokinetic concepts to analysis of microdialysis data: illustration with imipenem muscle distribution

27 July 2018

1 reference

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27 July 2018

Parenteral carbapenems

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Effectiveness of cephalosporins in the sputum of patients with nosocomial bronchopneumonia

27 July 2018

1 reference

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Antibacterial dosing in intensive care: pharmacokinetics, degree of disease and pharmacodynamics of sepsis

27 July 2018

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Antimicrobial therapy in critically ill patients: a review of pathophysiological conditions responsible for altered disposition and pharmacokinetic variability

27 July 2018

1 reference

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Continuous versus intermittent intravenous administration of antibiotics: a meta-analysis of randomised controlled trials

27 July 2018

1 reference

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How monitoring of the microcirculation may help us at the bedside

27 July 2018

1 reference

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Comparison of the pharmacodynamics of meropenem in patients with ventilator-associated pneumonia following administration by 3-hour infusion or bolus injection.

27 July 2018

1 reference

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Pharmacokinetics and pharmacodynamics of cefpirome in subcutaneous adipose tissue of septic patients.

27 July 2018

1 reference

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Pharmacokinetics and pharmacodynamics of meropenem in febrile neutropenic patients with bacteremia

27 July 2018

1 reference

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Antibiotic pharmacokinetic and pharmacodynamic considerations in critical illness

27 July 2018

1 reference

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Basic pharmacodynamics of antibacterials with clinical applications to the use of beta-lactams, glycopeptides, and linezolid

27 July 2018

1 reference

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The pharmacokinetics of the interstitial space in humans

27 July 2018

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Pharmacokinetics and pharmacodynamics of meropenem in critically ill patients

27 July 2018

1 reference

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Gentamicin dosing in critically ill patients

27 July 2018

1 reference

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Low cefpirome levels during twice daily dosing in critically ill septic patients: pharmacokinetic modelling calls for more frequent dosing.

27 July 2018

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Pharmacokinetics of cefepime in patients with thermal burn injury

27 July 2018

1 reference

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Low plasma cefepime levels in critically ill septic patients: pharmacokinetic modeling indicates improved troughs with revised dosing

27 July 2018

1 reference

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Altered pharmacokinetics of ceftazidime in critically ill patients

27 July 2018

1 reference

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Continuous infusion versus intermittent administration of meropenem in critically ill patients

27 July 2018

1 reference

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Pharmacokinetic-pharmacodynamic modeling of activity of ceftazidime during continuous and intermittent infusion.

27 July 2018

1 reference

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Continuous infusion versus intermittent administration of ceftazidime in critically ill patients with suspected gram-negative infections

27 July 2018

1 reference

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Clinical pharmacokinetics of piperacillin-tazobactam combination in patients with major burns and signs of infection

27 July 2018

1 reference

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Penetration of piperacillin-tazobactam into bronchial secretions after multiple doses to intensive care patients

27 July 2018

1 reference

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Multiple-dose pharmacokinetics of imipenem-cilastatin

27 July 2018

1 reference

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Ceftazidime in the treatment of Pseudomonas infections in intensive-care patients.

27 July 2018

1 reference

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Effects of treatment and the metabolic response to injury on drug clearance: a prospective study with piperacillin.

27 July 2018

1 reference

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Randomized comparison of cefepime and ceftazidime for treatment of skin, surgical wound, and complicated urinary tract infections in hospitalized subjects

27 July 2018

1 reference

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Pharmacokinetics of cefepime after single and multiple intravenous administrations in healthy subjects

27 July 2018

1 reference

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Pharmacokinetics of meropenem and its metabolite in young and elderly healthy men

27 July 2018

1 reference

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Endotracheal and aerosol administrations of ceftazidime in patients with nosocomial pneumonia: pharmacokinetics and absolute bioavailability

27 July 2018

1 reference

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Comparative study of pharmacokinetics and serum bactericidal activities of cefpirome, ceftazidime, ceftriaxone, imipenem, and ciprofloxacin

27 July 2018

1 reference

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A comparison of estimates of glomerular filtration in critically ill patients with augmented renal clearance

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Therapeutic drug monitoring of beta-lactams in critically ill patients: proof of concept

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Prospective determination of serum ceftazidime concentrations in intensive care units

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

International study of the prevalence and outcomes of infection in intensive care units

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Pharmacodynamic-based clinical pathway for empiric antibiotic choice in patients with ventilator-associated pneumonia.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Piperacillin penetration into tissue of critically ill patients with sepsis--bolus versus continuous administration?

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Population pharmacokinetics of high-dose, prolonged-infusion cefepime in adult critically ill patients with ventilator-associated pneumonia

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Comparison of the pharmacodynamics of imipenem in patients with ventilator-associated pneumonia following administration by 2 or 0.5 h infusion.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Glomerular hyperfiltration and albuminuria in critically ill patients

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Alveolar concentrations of piperacillin/tazobactam administered in continuous infusion to patients with ventilator-associated pneumonia

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Cefepime in intensive care unit patients: validation of a population pharmacokinetic approach and influence of covariables.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Serum markers in community-acquired pneumonia and ventilator-associated pneumonia.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T>MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Pharmacokinetics of ceftazidime and cefepime in burn patients: the importance of age and creatinine clearance.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Comparison of the pharmacokinetics of piperacillin and sulbactam during intermittent and continuous intravenous infusion

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Population pharmacokinetics and pharmacodynamics of continuous versus short-term infusion of imipenem-cilastatin in critically ill patients in a randomized, controlled trial

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Pharmacokinetics and pharmacodynamics of antimicrobials

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Contemporary activity of meropenem and comparator broad-spectrum agents: MYSTIC program report from the United States component (2005).

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Pharmacokinetic-pharmacodynamic rationale for cefepime dosing regimens in intensive care units.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

A retrospective analysis using Monte Carlo simulation to evaluate recommended ceftazidime dosing regimens in healthy volunteers, patients with cystic fibrosis, and patients in the intensive care unit

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Pharmacokinetic evaluation of meropenem and imipenem in critically ill patients with sepsis

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Steady-state plasma and intrapulmonary concentrations of piperacillin/tazobactam 4 g/0.5 g administered to critically ill patients with severe nosocomial pneumonia

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Plasma and lung concentrations of ceftazidime administered in continuous infusion to critically ill patients with severe nosocomial pneumonia

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Imipenem levels are not predictable in the critically ill patient

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Impact of pharmacodynamics on breakpoint selection for susceptibility testing

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Cefepime versus cefpirome: the importance of creatinine clearance

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Steady-state plasma and intrapulmonary concentrations of cefepime administered in continuous infusion in critically ill patients with severe nosocomial pneumonia

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Tissue distribution of imipenem in critically ill patients

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Cefepime-induced neurotoxicity: an underestimated complication of antibiotherapy in patients with acute renal failure

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Pharmacokinetics of ceftazidime in serum and peritoneal exudate during continuous versus intermittent administration to patients with severe intra-abdominal infections

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Impaired target site penetration of beta-lactams may account for therapeutic failure in patients with septic shock

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Pharmacokinetic-pharmacodynamic evaluation of ceftazidime continuous infusion vs intermittent bolus injection in septicaemic melioidosis

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Meropenem pharmacokinetics and pharmacodynamics in patients with ventilator-associated pneumonia.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

The epidemiology of the systemic inflammatory response

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Intermittent bolus dosing of ceftazidime in critically ill patients.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334750

Gentamicin volume of distribution in critically ill septic patients

24 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2FCC10441

Continuous infusion ceftazidime in intensive care: a randomized controlled trial

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2FCC10441

Pharmacokinetics of Meropenem Determined by Microdialysis in the Peritoneal Fluid of Patients With Severe Peritonitis Associated With Septic Shock

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2FCC10441

Penetration of ceftazidime into bronchial secretions in critically ill patients

21 January 2018

1 reference

12 December 2020

Pharmacokinetics of cefepime in patients with the sepsis syndrome

1 reference

12 December 2020

The pharmacokinetics of meropenem in surgical patients with moderate or severe infections

1 reference

12 December 2020

Pharmacokinetics of aztreonam and imipenem in critically ill patients with pneumonia

1 reference

12 December 2020

Review of pharmacokinetics and pharmacodynamics of antimicrobial agents

1 reference

12 December 2020

Pharmacokinetics of cefpirome during the posttraumatic systemic inflammatory response syndrome

1 reference

12 December 2020

Imipenem penetration into bronchial secretions

1 reference

12 December 2020

Plasma, urine and skin pharmacokinetics of cefepime in burns patients

1 reference

12 December 2020

Intermittent and continuous ceftazidime infusion for critically ill trauma patients

1 reference

12 December 2020

Plasma and tissue pharmacokinetics of cefpirome in patients with sepsis

1 reference

12 December 2020

Surveillance of antimicrobial use and antimicrobial resistance in United States hospitals: project ICARE phase 2. Project Intensive Care Antimicrobial Resistance Epidemiology (ICARE) hospitals

1 reference

12 December 2020

Clinical efficacy of continuous infusion of piperacillin compared with intermittent dosing in septic critically ill patients

1 reference

12 December 2020

Influence of renal function on trough serum concentrations of piperacillin in intensive care unit patients

1 reference

12 December 2020

Population pharmacokinetics and pharmacodynamics of cefpirome in critically ill patients against Gram-negative bacteria

1 reference

12 December 2020

Identifiers

DOI

10.1186/CC10441

1 reference

Dimensions Publication ID

11 August 2017

0 references

1 reference

11 August 2017

1 reference