In the absence of CD154, administration of interleukin-12 restores Th1 responses but not protective immunity to Schistosoma mansoni (Q35913558)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17485453%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

title

In the absence of CD154, administration of interleukin-12 restores Th1 responses but not protective immunity to Schistosoma mansoni (English)

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30 December 2019

0 references

1

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30 December 2019

author name string

Paul A Hamblin

series ordinal

2

1 reference

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30 December 2019

Adrian P Mountford

series ordinal

3

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30 December 2019

language of work or name

English

0 references

publication date

7 May 2007

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30 December 2019

published in

Infection and Immunity

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30 December 2019

volume

75

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30 December 2019

issue

7

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30 December 2019

page(s)

3539-3547

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CD207+ Langerhans cells constitute a minor population of skin-derived antigen-presenting cells in the draining lymph node following exposure to Schistosoma mansoni

30 December 2019

cites work

1 reference

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CD40/CD154 interactions are required for the optimal maturation of skin-derived APCs and the induction of helminth-specific IFN-gamma but not IL-4.

11 July 2018

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Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk

11 July 2018

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Resistance to re-infection after exposure to normal and attenuated schistosome parasites in the baboon model

11 July 2018

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Immunity induced by the radiation-attenuated schistosome vaccine

11 July 2018

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Immunopathogenesis of schistosomiasis

11 July 2018

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Schistosomes in the skin: a balance between immune priming and regulation

11 July 2018

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CD40/CD154 interactions at the interface of tolerance and immunity

11 July 2018

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Interleukin-12 p40 secretion by cutaneous CD11c+ and F4/80+ cells is a major feature of the innate immune response in mice that develop Th1-mediated protective immunity to Schistosoma mansoni

11 July 2018

1 reference

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CD40 can costimulate human memory T cells and favors IL-10 secretion

11 July 2018

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CD40-CD40 ligand costimulation is not required for initiation and maintenance of a Th1-type response to Leishmania major infection

11 July 2018

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The CD40/CD154 receptor/ligand dyad

11 July 2018

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Signaling via interleukin-4 receptor alpha chain is required for successful vaccination against schistosomiasis in BALB/c mice

11 July 2018

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Defining a schistosomiasis vaccination strategy - is it really Th1 versus Th2?

11 July 2018

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CD40-CD40 ligand interactions in vivo regulate migration of antigen-bearing dendritic cells from the skin to draining lymph nodes

11 July 2018

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Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process

11 July 2018

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The CD40/CD40 ligand interaction is required for resistance to toxoplasmic encephalitis.

11 July 2018

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Immune responses to the radiation-attenuated schistosome vaccine: what can we learn from knock-out mice?

11 July 2018

1 reference

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Inducible nitric oxide synthase-deficient mice develop enhanced type 1 cytokine-associated cellular and humoral immune responses after vaccination with attenuated Schistosoma mansoni cercariae but display partially reduced resistance

11 July 2018

1 reference

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CD40 ligand is not essential for induction of type 1 cytokine responses or protective immunity after primary or secondary infection with histoplasma capsulatum

11 July 2018

1 reference

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The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.

11 July 2018

1 reference

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High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

11 July 2018

1 reference

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Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion

11 July 2018

1 reference

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CD40-mediated stimulation contributes to lymphocyte proliferation, antibody production, eosinophilia, and mastocytosis during an in vivo type 2 response, but is not required for T cell IL-4 production.

11 July 2018

1 reference

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Activation of human dendritic cells through CD40 cross-linking.

11 July 2018

1 reference

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A role for CD4+ but not CD8+ T cells in immunity to Schistosoma mansoni induced by 20 krad-irradiated and Ro 11-3128-terminated infections

11 July 2018

1 reference

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Evidence for enhancement of IgG1 subclass expression in mice polyvaccinated with radiation-attenuated cercariae of Schistosoma mansoni and the role of this isotype in serum-transferred immunity.

11 July 2018

1 reference

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The generation of interferon-gamma-producing T lymphocytes in skin-draining lymph nodes, and their recruitment to the lungs, is associated with protective immunity to Schistosoma mansoni

11 July 2018

1 reference

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Disruption of CD40-CD40 ligand pathway inhibits the development of intestinal muscle hypercontractility and protective immunity in nematode infection.

11 July 2018

1 reference

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CD40 engagement enhances antigen-presenting langerhans cell priming of IFN-gamma-producing CD4+ and CD8+ T cells independently of IL-12.

24 September 2018

1 reference

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An IL-12-independent role for CD40-CD154 in mediating effector responses: studies in cell-mediated glomerulonephritis and dermal delayed-type hypersensitivity

24 September 2018

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CD40 signaling converts a minimally immunogenic antigen into a potent vaccine against the intracellular pathogen Listeria monocytogenes.

24 September 2018

1 reference

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TNF is essential for the cell-mediated protective immunity induced by the radiation-attenuated schistosome vaccine.

24 September 2018

1 reference

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Disruption of CD154:CD40 blocks generation of allograft immunity without affecting APC activation.

24 September 2018

1 reference

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Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1932915

The radiation-attenuated schistosome vaccine induces high levels of protective immunity in the absence of B cells.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1932915

Formation of multinucleated giant cells in the mouse lung is promoted in the absence of interleukin-12.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1932915

CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1932915

Induction of Th1 cell-mediated protective immunity to Schistosoma mansoni by co-administration of larval antigens and IL-12 as an adjuvant.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1932915

IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1932915

CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1932915

The development of a Th1-type response and resistance to Leishmania major infection in the absence of CD40-CD40L costimulation

14 November 2018

1 reference

12 December 2020

Cutting edge: Th2 response induction by dendritic cells: a role for CD40

1 reference

12 December 2020

Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interaction

1 reference

12 December 2020

CD40/CD40 ligand interactions in the host defense against disseminated Candida albicans infection: the role of macrophage-derived nitric oxide

1 reference

12 December 2020

Dendritic cells recruited to the lung shortly after intranasal delivery of Mycobacterium bovis BCG drive the primary immune response towards a type 1 cytokine production

1 reference

12 December 2020

CD40 preferentially costimulates activation of CD4+ T lymphocytes

1 reference

12 December 2020

Altered T helper responses in CD40 and interleukin-12 deficient mice reveal a critical role for Th1 responses in eliminating the helminth parasite Taenia crassiceps

1 reference

12 December 2020

IL-10 regulates early IL-12-mediated immune responses induced by the radiation-attenuated schistosome vaccine

1 reference

12 December 2020

CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberculosis infection

1 reference

12 December 2020

Mice deficient for the CD40 ligand

1 reference

12 December 2020

Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice

1 reference

12 December 2020

CD40 ligand is required for protective cell-mediated immunity to Leishmania major

1 reference

12 December 2020

Impaired immunity and altered pulmonary responses in mice with a disrupted interferon-gamma receptor gene exposed to the irradiated Schistosoma mansoni vaccine

1 reference

12 December 2020

Accessory signaling by CD40 for T cell activation: induction of Th1 and Th2 cytokines and synergy with interleukin-12 for interferon-gamma production

1 reference

12 December 2020

The induction of a protective response in Leishmania major-infected BALB/c mice with anti-CD40 mAb

1 reference

12 December 2020

Nitric oxide produced in the lungs of mice immunized with the radiation-attenuated schistosome vaccine is not the major agent causing challenge parasite elimination

1 reference

12 December 2020

In the absence of IL-12, the induction of Th1-mediated protective immunity by the attenuated schistosome vaccine is impaired, revealing an alternative pathway with Th2-type characteristics

1 reference

12 December 2020

Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-gamma-dependent effector mechanisms

1 reference

12 December 2020

CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help

1 reference

12 December 2020

CD40 antibody as a potent immunological adjuvant: CD40 antibody provides the CD40 signal to B cells, but does not substitute for T cell help in responses to TD antigens

1 reference

12 December 2020

Activated T cells enhance nitric oxide production by murine splenic macrophages through gp39 and LFA-1

1 reference

12 December 2020

IFN-gamma is necessary but not sufficient for anti-CD40 antibody-mediated inhibition of the Th2 response to Schistosoma mansoni eggs

1 reference

12 December 2020

A role for parasite-induced PGE2 in IL-10-mediated host immunoregulation by skin stage schistosomula of Schistosoma mansoni

1 reference

12 December 2020

Identifiers

DOI

10.1128/IAI.00252-07

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17485453%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17485453%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1 reference