Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates (Q35921980)

11 August 2017

Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates (English)

1 reference

11 August 2017

7

Joann B Sweasy

1 reference

11 August 2017

Alireza G Senejani

1

1 reference

11 August 2017

Shibani Dalal

2

1 reference

11 August 2017

Yanfeng Liu

3

1 reference

11 August 2017

Timothy P Nottoli

4

1 reference

11 August 2017

James M McGrath

5

1 reference

11 August 2017

Connor S Clairmont

6

1 reference

11 August 2017

language of work or name

English

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publication date

9 April 2012

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11 August 2017

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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11 August 2017

109

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11 August 2017

17

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11 August 2017

6632-6637

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Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

DNA polymerase beta is critical for genomic stability of sperm cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

Mutational clusters generated by non-processive polymerases: A case study using DNA polymerase betain vitro

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

Distribution and roles of X-family DNA polymerases in eukaryotes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

DNA polymerases and human disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

The X family portrait: structural insights into biological functions of X family polymerases.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

Repair and genetic consequences of endogenous DNA base damage in mammalian cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

Is there a link between DNA polymerase beta and cancer?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

AP endonuclease-independent DNA base excision repair in human cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

Endogenous DNA damage in humans: a review of quantitative data

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

A mechanistic perspective on the chemistry of DNA repair glycosylases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

Biological consequences of free radical-damaged DNA bases.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

Backbone dynamics and refined solution structure of the N-terminal domain of DNA polymerase beta. Correlation with DNA binding and dRP lyase activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

A genetic system to identify DNA polymerase beta mutator mutants

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

Requirement of mammalian DNA polymerase-beta in base-excision repair.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

The use of shuttle vectors for mutation analysis in transgenic mice and rats.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340078

The mutator form of polymerase beta with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22493258

12 December 2020

inferred from PubMed ID database lookup

Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22493258

12 December 2020

inferred from PubMed ID database lookup

The comet assay: a method to measure DNA damage in individual cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22493258

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.1200800109

1 reference

11 August 2017

0 references

1 reference

11 August 2017

PubMed publication ID

22493258

1 reference