Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice (Q35946087)

11 August 2017

Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice (English)

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11 August 2017

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Miriam Merad

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Iannis Aifantis

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Hugo Mouquet

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Ralph M Steinman

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Juliana Idoyaga

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Fabienne Billiard

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Camille Lobry

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11 August 2017

Guillaume Darrasse-Jèze

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Janelle Waite

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11 August 2017

Xia Liu

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Amanda DaNave

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Michelle Tait

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11 August 2017

Marylène Leboeuf

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11 August 2017

Christos A Kyratsous

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11 August 2017

Jacquelynn Burton

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11 August 2017

Julie Kalter

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11 August 2017

Apostolos Klinakis

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11 August 2017

Wen Zhang

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11 August 2017

Gavin Thurston

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Andrew J Murphy

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George D Yancopoulos

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Dimitris Skokos

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11 August 2017

language of work or name

English

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publication date

30 April 2012

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Journal of Experimental Medicine

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209

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5

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1011-1028

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describes a project that uses

11 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3348095/fullTextXML

inferred from PubMed Central ID database lookup

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Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells

2 October 2017

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2 October 2017

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Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies

2 October 2017

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Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

2 October 2017

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T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function

2 October 2017

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Notch and wingless signaling cooperate in regulation of dendritic cell differentiation

2 October 2017

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In vivo analysis of dendritic cell development and homeostasis

2 October 2017

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Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus

2 October 2017

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Dendritic cell homeostasis

2 October 2017

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Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.

2 October 2017

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Regulatory T cells and immune tolerance

2 October 2017

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The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues

2 October 2017

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Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen.

2 October 2017

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CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS

2 October 2017

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Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

2 October 2017

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Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

2 October 2017

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Developmental regulation of Foxp3 expression during ontogeny.

2 October 2017

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Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

2 October 2017

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Heterogeneity of thymic dendritic cells

2 October 2017

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Regulatory T cell lineage specification by the forkhead transcription factor foxp3

2 October 2017

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Regulation of lymphoid development, differentiation, and function by the Notch pathway.

2 October 2017

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CD69 is an immunoregulatory molecule induced following activation

2 October 2017

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Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

2 October 2017

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CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.

2 October 2017

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In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

2 October 2017

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In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens

2 October 2017

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CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor

2 October 2017

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Multiple immuno-regulatory defects in type-1 diabetes

2 October 2017

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Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus.

2 October 2017

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Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells

2 October 2017

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348095

Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells.

2 October 2017

1 reference

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Chemokines and cell migration in secondary lymphoid organs

2 October 2017

1 reference

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The NOD mouse model of type 1 diabetes: as good as it gets?

2 October 2017

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Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny

2 October 2017

1 reference

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Quantitative impact of thymic clonal deletion on the T cell repertoire

2 October 2017

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Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation.

2 October 2017

1 reference

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Delta-like 4 is indispensable in thymic environment specific for T cell development

2 October 2017

1 reference

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Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo

11 July 2018

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TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes

11 July 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111615

Ongoing Dll4-Notch signaling is required for T-cell homeostasis in the adult thymus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111615

M-CSF: a novel plasmacytoid and conventional dendritic cell poietin

21 January 2018

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https://api.crossref.org/works/10.1084%2FJEM.20111615

Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111615

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111615

Conditional ablation of MHC-II suggests an indirect role for MHC-II in regulatory CD4 T cell maintenance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111615

Lasker Basic Medical Research Award. Dendritic cells: versatile controllers of the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111615

Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111615

Ameliorating effects of anti-Dll4 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111615

Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111615

A Guardian of T Cell Fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111615

T-cell apoptosis detected in situ during positive and negative selection in the thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111615

Expansion of CD4+ CD25+ Foxp3+ T cells by bone marrow-derived dendritic cells

21 January 2018

1 reference

12 December 2020

Notch signaling in the immune system

1 reference

12 December 2020

The Transcription Factor PU.1 Controls Dendritic Cell Development and Flt3 Cytokine Receptor Expression in a Dose-Dependent Manner

1 reference

12 December 2020

Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures

1 reference

12 December 2020

Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers

1 reference

12 December 2020

Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development

1 reference

12 December 2020

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1 reference

12 December 2020

Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice

1 reference

12 December 2020

Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20111615

1 reference

11 August 2017

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11 August 2017

PubMed publication ID

22547652

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