Efficacy of phosphatidylinositol-3 kinase inhibitors in a primary mouse model of undifferentiated pleomorphic sarcoma (Q35955302)

11 August 2017

Efficacy of phosphatidylinositol-3 kinase inhibitors in a primary mouse model of undifferentiated pleomorphic sarcoma (English)

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11 August 2017

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ChEBI release 2020-05-28

7

David G Kirsch

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11 August 2017

Suzy Kim

1

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11 August 2017

Rebecca D Dodd

2

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11 August 2017

Jeffrey K Mito

3

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11 August 2017

Yan Ma

4

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11 August 2017

Yongbaek Kim

5

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11 August 2017

Richard F Riedel

6

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11 August 2017

29 April 2012

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11 August 2017

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11 August 2017

2012

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11 August 2017

680708

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Creative Commons Attribution 3.0 Unported

11 August 2017

start time

1 January 2012

1 reference

April 2022 Public Data File from Crossref

Creative Commons Attribution 3.0 Unported

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copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

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Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines

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Gastric cancer growth control by BEZ235 in vivo does not correlate with PI3K/mTOR target inhibition but with [18F]FLT uptake

2 October 2017

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The combination of RAD001 and NVP-BEZ235 exerts synergistic anticancer activity against non-small cell lung cancer in vitro and in vivo

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Loss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor α

2 October 2017

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Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma

2 October 2017

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Combination therapy targeting both tumor-initiating and differentiated cell populations in prostate carcinoma

2 October 2017

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The efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 compared with rapamycin in renal cell carcinoma

2 October 2017

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Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

2 October 2017

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Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas

2 October 2017

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NVP-BEZ235 as a new therapeutic option for sarcomas.

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Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma

2 October 2017

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NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas

2 October 2017

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

2 October 2017

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

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NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

2 October 2017

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Doxorubicin-based chemotherapy for the palliative treatment of adult patients with locally advanced or metastatic soft-tissue sarcoma: a meta-analysis and clinical practice guideline

2 October 2017

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The mighty mouse: genetically engineered mouse models in cancer drug development

2 October 2017

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A spatially and temporally restricted mouse model of soft tissue sarcoma.

2 October 2017

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Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models

21 January 2018

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Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors.

21 January 2018

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Phase III Trial of Two Investigational Schedules of Ifosfamide Compared With Standard-Dose Doxorubicin in Advanced or Metastatic Soft Tissue Sarcoma: A European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Stud

21 January 2018

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21 January 2018

Identifiers

DOI

10.1155/2012/680708

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

22619567

1 reference