Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models (Q43056152)

13 November 2017

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models (English)

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13 November 2017

Gregory D Plowman

19

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author name string

Mallika Singh

1

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13 November 2017

Anthony Lima

2

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13 November 2017

Rafael Molina

3

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13 November 2017

Patricia Hamilton

4

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13 November 2017

Anne C Clermont

5

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13 November 2017

Vidusha Devasthali

6

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13 November 2017

Jennifer D Thompson

7

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13 November 2017

Jason H Cheng

8

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13 November 2017

Hani Bou Reslan

9

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13 November 2017

Calvin C K Ho

10

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13 November 2017

Timothy C Cao

11

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13 November 2017

Chingwei V Lee

12

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13 November 2017

Michelle A Nannini

13

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13 November 2017

Germaine Fuh

14

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13 November 2017

Richard A D Carano

15

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13 November 2017

Hartmut Koeppen

16

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13 November 2017

Ron X Yu

17

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13 November 2017

William F Forrest

18

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13 November 2017

Leisa Johnson

20

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13 November 2017

23 May 2010

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13 November 2017

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13 November 2017

28

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13 November 2017

585-593

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13 November 2017

6

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https://scigraph.springernature.com/pub.10.1038/nbt.1640

13 November 2017

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Genetically engineered models have advantages over xenografts for preclinical studies

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A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras

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Simultaneous inference in general parametric models

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Three-dimensional high-frequency ultrasound imaging for longitudinal evaluation of liver metastases in preclinical models

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Mutations and response to epidermal growth factor receptor inhibitors

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Oncogenes come of age.

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Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial.

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Pharmacodynamic separation of epidermal growth factor receptor tyrosine kinase inhibitors and chemotherapy in non-small-cell lung cancer

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Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer

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12 December 2020

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

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12 December 2020

Endpoints for assessing drug activity in clinical trials

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12 December 2020

Using genetically engineered mouse models of cancer to aid drug development: an industry perspective

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12 December 2020

Incorporation of adenovirus in calcium phosphate precipitates enhances gene transfer to airway epithelia in vitro and in vivo

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12 December 2020

Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib

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12 December 2020

Cancer modeling in the modern era: progress and challenges

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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

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12 December 2020

Untangling the ErbB signalling network

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Somatic mutations affect key pathways in lung adenocarcinoma

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Tumor-suppressive pathways in pancreatic carcinoma.

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EGFR antagonists in cancer treatment

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Blocking neuropilin-2 function inhibits tumor cell metastasis

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Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer

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Combined targeting of EGFR-dependent and VEGF-dependent pathways: rationale, preclinical studies and clinical applications

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12 December 2020

K‐Ras‐Driven Pancreatic Cancer Mouse Model for Anticancer Inhibitor Analyses

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12 December 2020

Determinants of RASistance to anti-epidermal growth factor receptor agents

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12 December 2020

Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer

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12 December 2020

Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group

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12 December 2020

Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer

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12 December 2020

Prognostic and Therapeutic Implications of EGFR and KRAS Mutations in Resected Lung Adenocarcinoma

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12 December 2020

Combined assessment of EGFR pathway-related molecular markers and prognosis of NSCLC patients

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12 December 2020

The use of xenograft models for the selection of cancer treatments with the EGFR as an example.

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12 December 2020

Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer

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12 December 2020

Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF.

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12 December 2020

Using whole genome amplification (WGA) of low-volume biopsies to assess the prognostic role of EGFR, KRAS, p53, and CMET mutations in advanced-stage non-small cell lung cancer (NSCLC)

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12 December 2020

Gastrosplenic fistula from Hodgkin's lymphoma

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Crossref

https://api.crossref.org/works/10.1038%2FNBT.1640

7 January 2021

inferred from DOI database lookup

The Efficiency of Cox's Likelihood Function for Censored Data

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNBT.1640

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NBT.1640

1 reference

13 November 2017

1 reference