Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24 (Q35958478)

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26 January 2020

title

Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24 (English)

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4

Hea-Jin Jung

1 reference

26 January 2020

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Loren G Fong

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26 January 2020

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Sandy Y Chang

1

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26 January 2020

Sarah E Hudon-Miller

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Shao H Yang

3

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26 January 2020

John M Lee

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26 January 2020

Emily Farber

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26 January 2020

Thangaiah Subramanian

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Douglas A Andres

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H Peter Spielmann

9

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26 January 2020

Christine A Hrycyna

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26 January 2020

publication date

23 March 2012

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Journal of Lipid Research

26 January 2020

published in

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26 January 2020

volume

53

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issue

6

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26 January 2020

page(s)

1176-1182

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Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases.

26 January 2020

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An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria

2 October 2017

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2 October 2017

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Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides

2 October 2017

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Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated.

2 October 2017

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HIV-protease inhibitors block the enzymatic activity of purified Ste24p.

2 October 2017

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2 October 2017

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A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells

2 October 2017

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HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells.

2 October 2017

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GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer

2 October 2017

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2 October 2017

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Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis

2 October 2017

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2 October 2017

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Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes

2 October 2017

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Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

2 October 2017

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Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

2 October 2017

1 reference

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Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24

2 October 2017

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Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.

2 October 2017

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Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models

2 October 2017

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Biochemical studies of Zmpste24-deficient mice

2 October 2017

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The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities

2 October 2017

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Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells

2 October 2017

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Cloning and characterization of a mammalian prenyl protein-specific protease

2 October 2017

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Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum

2 October 2017

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

2 October 2017

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Modulation of Ras and a-factor function by carboxyl-terminal proteolysis

2 October 2017

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2 October 2017

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2 October 2017

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The processing pathway of prelamin A

2 October 2017

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2 October 2017

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Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae

2 October 2017

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2 October 2017

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The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins

2 October 2017

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cDNA cloning and expression of the peptide-binding β subunit of rat p21rasfarnesyltransferase, the counterpart of yeast DPR1/RAM1

2 October 2017

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Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina

2 October 2017

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Protein isoprenylation and methylation at carboxyl-terminal cysteine residues

2 October 2017

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Protein prenylation: genes, enzymes, targets, and functions.

2 October 2017

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The farnesyl protein transferase inhibitor BZA-5B blocks farnesylation of nuclear lamins and p21ras but does not affect their function or localization.

2 October 2017

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Edible vaccines: not quite ready for prime time

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Crossref

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Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

21 January 2018

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Crossref

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Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.

21 January 2018

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Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

24 September 2018

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The role of isoprenylation in membrane attachment of nuclear lamins. A single point mutation prevents proteolytic cleavage of the lamin A precursor and confers membrane binding properties

24 September 2018

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Expression systems for nuclear lamin proteins: farnesylation in assembly of nuclear lamina

14 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22448028

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

In vitro assay and characterization of the farnesylation-dependent prelamin A endoprotease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22448028

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1194/JLR.M026161

1 reference

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26 January 2020

1 reference

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26 January 2020

1 reference