Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration (Q35971649)

11 August 2017

Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration (English)

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Glucocerebrosidase 1a Dmel_CG31148

11 August 2017

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Glucocerebrosidase 1b Dmel_CG31414

GOA release 2020-03-11

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GOA release 2020-03-11

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Thomas J Montine

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11 August 2017

Marie Y Davis

1

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11 August 2017

Kien Trinh

2

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11 August 2017

Ruth E Thomas

3

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11 August 2017

Selina Yu

4

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11 August 2017

Alexandre A Germanos

5

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11 August 2017

Brittany N Whitley

6

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11 August 2017

Sergio Pablo Sardi

7

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11 August 2017

Leo J Pallanck

9

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11 August 2017

language of work or name

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28 March 2016

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11 August 2017

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11 August 2017

e1005944

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Creative Commons Attribution 4.0 International

11 August 2017

start time

28 March 2016

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death

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Lipids in Amyloid-β Processing, Aggregation, and Toxicity

2 October 2017

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Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein

2 October 2017

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Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation

2 October 2017

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2 October 2017

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LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance

2 October 2017

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Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates.

2 October 2017

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Glucocerebrosidase is shaking up the synucleinopathies

2 October 2017

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Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease

2 October 2017

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Glucocerebrosidase mutations and the pathogenesis of Parkinson disease

2 October 2017

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New insights on glucosylated lipids: Metabolism and functions

2 October 2017

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Gaucher disease: a comprehensive review

2 October 2017

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Prion-like spreading of pathological α-synuclein in brain

2 October 2017

1 reference

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Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies

2 October 2017

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Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

2 October 2017

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Gaucher disease: insights from a rare Mendelian disorder

2 October 2017

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The link between the GBA gene and parkinsonism

2 October 2017

1 reference

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Fiji: an open-source platform for biological-image analysis

2 October 2017

1 reference

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Ceramide function in the brain: when a slight tilt is enough.

2 October 2017

1 reference

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Parkinson's disease and α-synuclein expression

2 October 2017

1 reference

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Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

2 October 2017

1 reference

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Robust RT-qPCR data normalization: validation and selection of internal reference genes during post-experimental data analysis

2 October 2017

1 reference

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Identification of functional elements and regulatory circuits by Drosophila modENCODE

2 October 2017

1 reference

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Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases

2 October 2017

1 reference

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The role of the ceramide acyl chain length in neurodegeneration: involvement of ceramide synthases

2 October 2017

1 reference

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The role of glucocerebrosidase mutations in Parkinson disease and Lewy body disorders

2 October 2017

1 reference

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The risk of Parkinson's disease in type 1 Gaucher disease

2 October 2017

1 reference

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Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.

2 October 2017

1 reference

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Glucocerebrosidase gene mutations: a risk factor for Lewy body disorders

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Using FlyAtlas to identify better Drosophila melanogaster models of human disease

2 October 2017

1 reference

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Non-motor dysfunction in Parkinson's disease

2 October 2017

1 reference

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Sphingolipids and cell death.

2 October 2017

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

2 October 2017

1 reference

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Drosophila models pioneer a new approach to drug discovery for Parkinson's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

alpha-Synuclein locus triplication causes Parkinson's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Salvage pathways in glycosphingolipid metabolism

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

A Drosophila model of Parkinson's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Genetic Transformation of Drosophila with Transposable Element Vectors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Indirect Suppression Involving Behavioral Mutants with Altered Nerve Excitability in DROSOPHILA MELANOGASTER.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Metabolic disruption in Drosophila bang-sensitive seizure mutants

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Arthrin, a myofibrillar protein of insect flight muscle, is an actin-ubiquitin conjugate.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Monitoring autophagic flux using Ref(2)P, the Drosophila p62 ortholog.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Differential phenotype in Parkinson's disease patients with severe versus mild GBA mutations.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Glucocerebrosidase mutations are an important risk factor for Lewy body disorders.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Lipid binding inhibits alpha-synuclein fibril formation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Parkinson's syndrome preceding clinical manifestation of Gaucher's disease.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809718

Gaucher disease and parkinsonism: a phenotypic and genotypic characterization

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27019408

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PGEN.1005944

1 reference

11 August 2017

1 reference

11 August 2017

1 reference