VEGF Receptor-2-Linked PI3K/Calpain/SIRT1 Activation Mediates Retinal Arteriolar Dilations to VEGF and Shear Stress (Q35980480)

11 August 2017

VEGF Receptor-2-Linked PI3K/Calpain/SIRT1 Activation Mediates Retinal Arteriolar Dilations to VEGF and Shear Stress (English)

1 reference

11 August 2017

Travis W Hein

1

1 reference

11 August 2017

Robert H Rosa

2

1 reference

11 August 2017

Yi Ren

3

1 reference

11 August 2017

Wenjuan Xu

4

1 reference

11 August 2017

Lih Kuo

5

1 reference

11 August 2017

language of work or name

English

0 references

publication date

1 August 2015

1 reference

Investigative Ophthalmology Visual Science

11 August 2017

1 reference

11 August 2017

56

1 reference

11 August 2017

9

1 reference

11 August 2017

5381-5389

1 reference

Role of endothelium in vasomotor responses to endothelin system and protein kinase C activation in porcine retinal arterioles

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

The role of SIRT1 in ocular aging

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Hypo- and hyperglycemia impair endothelial cell actin alignment and nitric oxide synthase activation in response to shear stress.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Clostridium perfringens beta-toxin induces necrostatin-inhibitable, calpain-dependent necrosis in primary porcine endothelial cells

2 October 2017

1 reference

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Anti-Vascular endothelial growth factor therapy impairs endothelial function of retinal microcirculation in colon cancer patients - an observational study

2 October 2017

1 reference

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Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Retinal arteriolar responses to acute severe elevation in systemic blood pressure in cats: role of endothelium-derived factors

2 October 2017

1 reference

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An experimental study of VEGF induced changes in vasoactivity in pig retinal arterioles and the influence of an anti-VEGF agent

2 October 2017

1 reference

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Fluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices

2 October 2017

1 reference

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Retinal blood flow in response to an intravitreal injection of ranibizumab for neovascular age-related macular degeneration.

2 October 2017

1 reference

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The effect of intravitreal injection of bevacizumab on retinal circulation in patients with neovascular macular degeneration

2 October 2017

1 reference

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Shear stress, SIRT1, and vascular homeostasis

2 October 2017

1 reference

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Divergent roles of nitric oxide and rho kinase in vasomotor regulation of human retinal arterioles

2 October 2017

1 reference

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Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression

2 October 2017

1 reference

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Recent progress in the biology and physiology of sirtuins

2 October 2017

1 reference

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Correlation of flicker-induced and flow-mediated vasodilatation in patients with endothelial dysfunction and healthy volunteers

2 October 2017

1 reference

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Functional and molecular characterization of the endothelin system in retinal arterioles

2 October 2017

1 reference

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An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production

2 October 2017

1 reference

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Age impairs Flk-1 signaling and NO-mediated vasodilation in coronary arterioles

2 October 2017

1 reference

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Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits

2 October 2017

1 reference

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Regulation of retinal blood flow in health and disease.

2 October 2017

1 reference

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Vitreous levels of stromal cell-derived factor 1 and vascular endothelial growth factor in patients with retinopathy of prematurity

2 October 2017

1 reference

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SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase

2 October 2017

1 reference

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Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity

2 October 2017

1 reference

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Arteriolar involvement in the microvascular lesions of diabetic retinopathy: implications for pathogenesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Shear stress biology of the endothelium

2 October 2017

1 reference

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Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Impaired endothelial function of the retinal vasculature in hypertensive patients

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Diffuse luminance flicker increases blood flow in major retinal arteries and veins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Nitric oxide regulates retinal vascular tone in humans

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

The effect of nitric oxide on retinal blood flow during hypoxia in cats.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

KDR (VEGF receptor 2) is the major mediator for the hypotensive effect of VEGF

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation

2 October 2017

1 reference

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Evaluation of the Zeiss retinal vessel analyser

2 October 2017

1 reference

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Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Flk-1 as a target for tumor growth inhibition.

2 October 2017

1 reference

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Levels of vascular endothelial growth factor are elevated in the vitreous of patients with subretinal neovascularisation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Detection of vascular endothelial growth factor messenger RNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Blood velocity and volumetric flow rate in human retinal vessels

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Blood flow in the normal human retina

2 October 2017

1 reference

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Temporal development of retinal arteriolar endothelial dysfunction in porcine type 1 diabetes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Calpain inhibitor SNJ-1945 attenuates events prior to angiogenesis in cultured human retinal endothelial cells

27 July 2018

1 reference

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Dilator response of rat mesenteric arcading arterioles to increased blood flow velocity

27 July 2018

1 reference

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Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis

27 July 2018

1 reference

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Retinal blood flow velocity in patients with age-related macular degeneration.

27 July 2018

1 reference

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Long-term results of the effect of intravitreal ranibizumab on the retinal arteriolar diameter in patients with neovascular age-related macular degeneration.

24 September 2018

1 reference

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Modeling of diseases of retinal ischemia in vitro: possible participation of autocrine vascular endothelial growth factor signaling

24 September 2018

1 reference

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Regulation of cerebral vascular function by sirtuin 1.

24 September 2018

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Endothelial dysfunction is related to poor glycemic control in adolescents with type 1 diabetes under 5 years of disease: evidence of metabolic memory

24 September 2018

1 reference

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Intravitreal ranibizumab may induce retinal arteriolar vasoconstriction in patients with neovascular age-related macular degeneration.

24 September 2018

1 reference

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Long-term glycemic control influences the long-lasting effect of hyperglycemia on endothelial function in type 1 diabetes.

24 September 2018

1 reference

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Activity-dependent calpain activation plays a critical role in synaptic facilitation and post-tetanic potentiation

24 September 2018

1 reference

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Optical coherence tomography and vessel diameter changes after intravitreal bevacizumab in diabetic macular oedema

24 September 2018

1 reference

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Resveratrol, a component of red wine, elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channels

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Requisite roles of A2A receptors, nitric oxide, and KATP channels in retinal arteriolar dilation in response to adenosine

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Corticosteroids inhibit VEGF-induced vascular leakage in a rabbit model of blood-retinal and blood-aqueous barrier breakdown

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Exercise training enhances vasodilation responses to vascular endothelial growth factor in porcine coronary arterioles exposed to chronic coronary occlusion

24 September 2018

1 reference

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Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase

24 September 2018

1 reference

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Spatial heterogeneity in VEGF-induced vasodilation: VEGF dilates microvessels but not epicardial and systemic arteries and veins

24 September 2018

1 reference

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ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration.

24 September 2018

1 reference

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Angiotensin II and vascular endothelial growth factor in the vitreous fluid of patients with diabetic macular edema and other retinal disorders

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc.

24 September 2018

1 reference

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Vascular endothelial growth factor/vascular permeability factor produces nitric oxide-dependent hypotension. Evidence for a maintenance role in quiescent adult endothelium.

24 September 2018

1 reference

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Vascular endothelial growth factor and severity of nonproliferative diabetic retinopathy mediate retinal hemodynamics in vivo: a potential role for vascular endothelial growth factor in the progression of nonproliferative diabetic retinopathy

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Hypoxic induction of endothelial cell growth factors in retinal cells: identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4544352

Diameter of retinal vessels in patients with diabetic macular edema is not altered by intravitreal ranibizumab (lucentis).

24 September 2018

1 reference

12 December 2020

Upregulation of vascular endothelial growth factor in ischemic and non-ischemic human and experimental retinal disease

1 reference

12 December 2020

Vascular Endothelial Growth Factor-Induced Migration of Vascular Smooth Muscle Cells in Vitro

1 reference

12 December 2020

Effect of nos inhibition on retinal arterial and capillary circulation in early arterial hypertension

1 reference

12 December 2020

Effect of shear stress on the hydraulic conductivity of cultured bovine retinal microvascular endothelial cell monolayers

1 reference

12 December 2020

Direct measurement of retinal microvascular pressures in the live, anesthetized cat

1 reference

12 December 2020

Postischemic vasodilation in human forearm is dependent on endothelium-derived nitric oxide

1 reference

12 December 2020

Endothelium-dependent, flow-induced dilation of isolated coronary arterioles

1 reference

12 December 2020

Levels of VEGF but not VEGF 165b are Increased in the Vitreous of Patients With Retinal Vein Occlusion

1 reference

12 December 2020

Comparison of the autoregulatory mechanisms between central retinal artery and posterior ciliary arteries after thigh cuff deflation in healthy subjects

1 reference

12 December 2020

Impaired nitric oxide-mediated flow-induced dilation in arterioles of spontaneously hypertensive rats

1 reference

12 December 2020

Hypoxic regulation of vascular endothelial growth factor in retinal cells

1 reference

12 December 2020

Response of Retinal Vessels and Retrobulbar Hemodynamics to Intravitreal Anti-VEGF Treatment in Eyes with Branch Retinal Vein Occlusion

1 reference

12 December 2020

Identifiers

DOI

10.1167/IOVS15-16950

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

26284543

1 reference