Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes (Q36001763)

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English	Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes	scientific article

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scholarly article

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Europe PubMed Central

11 August 2017

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes (English)

1 reference

Europe PubMed Central

11 August 2017

phospholipid-transporting ATPase 1-like protein

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phospholipid-transporting ATPase 1-like protein

0 references

Leishmania infantum

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Sarah Hendrickx

3

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27123924%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

James A. Cotton

7

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4 June 2020

9

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4 June 2020

10

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4 June 2020

13

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4 June 2020

Francisco Gamarro

15

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4 June 2020

Santiago Castanys

16

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4 June 2020

17

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4 June 2020

author name string

Annelies Mondelaers

1

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4 June 2020

Maria P Sanchez-Cañete

2

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4 June 2020

Eline Eberhardt

4

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4 June 2020

Raquel Garcia-Hernandez

5

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4 June 2020

Laurence Lachaud

6

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4 June 2020

Mandy Sanders

8

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4 June 2020

Jean-Claude Dujardin

11

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4 June 2020

Peter Delputte

12

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4 June 2020

Guy Caljon

14

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4 June 2020

language of work or name

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publication date

28 April 2016

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Europe PubMed Central

11 August 2017

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4 June 2020

11

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4 June 2020

e0154101

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4 June 2020

4

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4 June 2020

copyright license

Creative Commons Attribution 4.0 International

28 April 2016

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April 2022 Public Data File from Crossref

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0 references

In vitro selection of miltefosine resistance in promastigotes of Leishmania donovani from Nepal: genomic and metabolomic characterization.

1 reference

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2 October 2017

In Vivo Selection of Paromomycin and Miltefosine Resistance in Leishmania donovani and L. infantum in a Syrian Hamster Model

1 reference

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2 October 2017

Experimental resistance to drug combinations in Leishmania donovani: metabolic and phenotypic adaptations.

1 reference

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2 October 2017

An update on pharmacotherapy for leishmaniasis

1 reference

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2 October 2017

Treatment failure in leishmaniasis: drug-resistance or another (epi-) phenotype?

1 reference

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2 October 2017

Failure of miltefosine in visceral leishmaniasis is associated with low drug exposure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

2 October 2017

Relapse after treatment with miltefosine for visceral leishmaniasis is associated with increased infectivity of the infecting Leishmania donovani strain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

2 October 2017

In vitro susceptibility of Leishmania donovani to miltefosine in Indian visceral leishmaniasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

2 October 2017

(Post-) Genomic approaches to tackle drug resistance in Leishmania.

1 reference

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2 October 2017

Increasing failure of miltefosine in the treatment of Kala-azar in Nepal and the potential role of parasite drug resistance, reinfection, or noncompliance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

2 October 2017

Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

2 October 2017

Experimental induction of paromomycin resistance in antimony-resistant strains of L. donovani: outcome dependent on in vitro selection protocol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

2 October 2017

Drug susceptibility in Leishmania isolates following miltefosine treatment in cases of visceral leishmaniasis and post kala-azar dermal leishmaniasis

1 reference

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2 October 2017

Fast gapped-read alignment with Bowtie 2

1 reference

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2 October 2017

Visceral leishmaniasis: elimination with existing interventions

1 reference

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2 October 2017

Integrative genomics viewer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

2 October 2017

TriTrypDB: a functional genomic resource for the Trypanosomatidae

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2 October 2017

The Sequence Alignment/Map format and SAMtools

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

2 October 2017

Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

2 October 2017

Comparative genomic analysis of three Leishmania species that cause diverse human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

2 October 2017

Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

2 October 2017

Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

2 October 2017

Oral miltefosine for Indian visceral leishmaniasis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

2 October 2017

MDR1 causes resistance to the antitumour drug miltefosine

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

2 October 2017

Leishmania resistance to miltefosine associated with genetic marker

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

11 July 2018

In vitro sensitivity testing of Leishmania clinical field isolates: preconditioning of promastigotes enhances infectivity for macrophage host cells

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11 July 2018

Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

11 July 2018

Intracellular amastigote replication may not be required for successful in vitro selection of miltefosine resistance in Leishmania infantum.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

23 September 2018

Proteomic analysis of the soluble proteomes of miltefosine-sensitive and -resistant Leishmania infantum chagasi isolates obtained from Brazilian patients with different treatment outcomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

23 September 2018

Multi-analytical platform metabolomic approach to study miltefosine mechanism of action and resistance in Leishmania.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

23 September 2018

Experimental selection of paromomycin and miltefosine resistance in intracellular amastigotes of Leishmania donovani and L. infantum.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

23 September 2018

Miltefosine-unresponsive Leishmania donovani has a greater ability than miltefosine-responsive L. donovani to resist reactive oxygen species.

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23 September 2018

In vitro susceptibilities of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differences

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23 September 2018

Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

23 September 2018

Parasite susceptibility to amphotericin B in failures of treatment for visceral leishmaniasis in patients coinfected with HIV type 1 and Leishmania infantum.

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23 September 2018

Synthesis of BODIPY-labeled alkylphosphocholines with leishmanicidal activity, as fluorescent analogues of miltefosine

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

23 September 2018

Concordant HIV infection and visceral leishmaniasis in Ethiopia: the influence of antiretroviral treatment and other factors on outcome

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23 September 2018

Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

23 September 2018

Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

23 September 2018

Functional role of evolutionarily highly conserved residues, N-glycosylation level and domains of the Leishmania miltefosine transporter-Cdc50 subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4849676

21 October 2018

Visceral and post-Kala-Azar dermal leishmaniasis isolates show significant difference in their in vitro drug susceptibility pattern

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0154101

21 January 2018

Comparative transcript expression analysis of miltefosine-sensitive and miltefosine-resistant Leishmania donovani

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0154101

21 January 2018

Long term failure of miltefosine in the treatment of refractory visceral leishmaniasis in AIDS patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/27123924

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-Term Monitoring of Visceral Leishmaniasis in Patients With AIDS

1 reference

https://pubmed.ncbi.nlm.nih.gov/27123924

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kala-azar elimination programme in India

1 reference

https://pubmed.ncbi.nlm.nih.gov/27123924

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy of miltefosine in the treatment of visceral leishmaniasis in India after a decade of use

1 reference

https://pubmed.ncbi.nlm.nih.gov/27123924

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0154101

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Europe PubMed Central

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4 June 2020

2016PLoSO..1154101M

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release_27jd4kye5fhvzandizvlnhqgoi

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24 November 2022

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Europe PubMed Central

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4 June 2020

1 reference

Europe PubMed Central

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4 June 2020

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