Multi-analytical platform metabolomic approach to study miltefosine mechanism of action and resistance in Leishmania (Q46907074)

26 December 2017

title

Multi-analytical platform metabolomic approach to study miltefosine mechanism of action and resistance in Leishmania (English)

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26 December 2017

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26 December 2017

Gisele A B Canuto

Gisele A B Canuto

Emerson A Castilho-Martins

1

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Emerson A Castilho-Martins

2

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Ángeles López-Gonzálvez

Ángeles López-Gonzálvez

6

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Luis Rivas

Luis Rivas

4

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author name string

Marina F M Tavares

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26 December 2017

language of work or name

English

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publication date

11 April 2014

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26 December 2017

Analytical and Bioanalytical Chemistry

published in

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26 December 2017

volume

406

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26 December 2017

issue

14

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26 December 2017

page(s)

3459-3476

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26 December 2017

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Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug

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Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites.

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani

21 January 2018

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Arginine homeostasis and transport in the human pathogen Leishmania donovani.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The biosynthetic incorporation of the intact leucine skeleton into sterol by the trypanosomatid Leishmania mexicana.

21 January 2018

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Highly specific methyl-end fatty-acid desaturases of trypanosomatids

21 January 2018

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A versatile proline/alanine transporter in the unicellular pathogen Leishmania donovani regulates amino acid homoeostasis and osmotic stress responses.

21 January 2018

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Disruption of the lipid-transporting LdMT-LdRos3 complex in Leishmania donovani affects membrane lipid asymmetry but not host cell invasion

21 January 2018

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21 January 2018

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The phagosome: compartment with a license to kill

21 January 2018

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CYP5122A1, a novel cytochrome P450 is essential for survival of Leishmania donovani

21 January 2018

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21 January 2018

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21 January 2018

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Central carbon metabolism of Leishmania parasites

21 January 2018

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Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones.

21 January 2018

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The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase

21 January 2018

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Lysine transporters in human trypanosomatid pathogens

21 January 2018

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10.1007/S00216-014-7772-1

21 January 2018

Identifiers

DOI

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26 December 2017

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26 December 2017