Multi-analytical platform metabolomic approach to study miltefosine mechanism of action and resistance in Leishmania (Q46907074)

26 December 2017

title

Multi-analytical platform metabolomic approach to study miltefosine mechanism of action and resistance in Leishmania (English)

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26 December 2017

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5

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26 December 2017

Gisele A B Canuto

Gisele A B Canuto

Emerson A Castilho-Martins

1

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Emerson A Castilho-Martins

2

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Ángeles López-Gonzálvez

Ángeles López-Gonzálvez

6

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Luis Rivas

Luis Rivas

4

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author name string

Marina F M Tavares

3

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26 December 2017

language of work or name

English

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publication date

11 April 2014

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26 December 2017

Analytical and Bioanalytical Chemistry

published in

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26 December 2017

volume

406

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26 December 2017

page(s)

3459-3476

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26 December 2017

issue

14

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26 December 2017

https://scigraph.springernature.com/pub.10.1007/s00216-014-7772-1

exact match

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cites work

Leishmaniasis worldwide and global estimates of its incidence

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Case study for a vaccine against leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Vaccine candidates for leishmaniasis: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Leishmaniasis chemotherapy--challenges and opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Combination therapy for visceral leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Leishmaniasis: an update of current pharmacotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Leishmaniasis and poverty

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Oral miltefosine for Indian visceral leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

In vitro susceptibility of field isolates of Leishmania donovani to Miltefosine and amphotericin B: correlation with sodium antimony gluconate susceptibility and implications for treatment in areas of endemicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Increasing failure of miltefosine in the treatment of Kala-azar in Nepal and the potential role of parasite drug resistance, reinfection, or noncompliance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Cell death in parasitic protozoa: regulated or incidental?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Synthesis and biological evaluation of fluorescent leishmanicidal analogues of hexadecylphosphocholine (miltefosine) as probes of antiparasite mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Choline transport in Leishmania major promastigotes and its inhibition by choline and phosphocholine analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Ether--lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether--lipid analogues in Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Cellular transport and lipid interactions of miltefosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Identification of phospholipid species affected by miltefosine action in Leishmania donovani cultures using LC-ELSD, LC-ESI/MS, and multivariate data analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Alteration of fatty acid and sterol metabolism in miltefosine-resistant Leishmania donovani promastigotes and consequences for drug-membrane interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Miltefosine (hexadecylphosphocholine) inhibits cytochrome c oxidase in Leishmania donovani promastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Miltefosine induces apoptosis-like cell death in yeast via Cox9p in cytochrome c oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Miltefosine-unresponsive Leishmania donovani has a greater ability than miltefosine-responsive L. donovani to resist reactive oxygen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Miltefosine resistance in Leishmania donovani involves suppression of oxidative stress-induced programmed cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Leishmania resistance to miltefosine associated with genetic marker

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Drug susceptibility in Leishmania isolates following miltefosine treatment in cases of visceral leishmaniasis and post kala-azar dermal leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Leishmania donovani develops resistance to drug combinations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Advances in separation science applied to metabonomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

NMR and pattern recognition methods in metabolomics: from data acquisition to biomarker discovery: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Quantitative NMR for bioanalysis and metabolomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Current metabolomics: technological advances

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Capillary electrophoresis as a metabolomics tool for non-targeted fingerprinting of biological samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

LC-MS metabolomics of polar compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Quantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: improved metabolite identification by retention time prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Lights and shadows on gene organization and regulation of gene expression in Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Paromomycin affects translation and vesicle-mediated trafficking as revealed by proteomics of paromomycin -susceptible -resistant Leishmania donovani

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Contribution of proteomics of Leishmania spp. to the understanding of differentiation, drug resistance mechanisms, vaccine and drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

A proteomics screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

LeishCyc: a biochemical pathways database for Leishmania major.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Metabolomic analysis of trypanosomatid protozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Metabolic pathways required for the intracellular survival of Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Metabolism of Leishmania: proven and predicted

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

The potential of metabolomics for Leishmania research in the post-genomics era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Metabolic characterization of Leishmania major infection in activated and nonactivated macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

CE-ESI-MS metabolic fingerprinting of Leishmania resistance to antimony treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Metabolomics to unveil and understand phenotypic diversity between pathogen populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Possible mechanism of miltefosine-mediated death of Leishmania donovani

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Miltefosine affects lipid metabolism in Leishmania donovani promastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Comparison between charged aerosol detection and light scattering detection for the analysis of Leishmania membrane phospholipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Arginine homeostasis and transport in the human pathogen Leishmania donovani.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Axenic Leishmania amazonensis promastigotes sense both the external and internal arginine pool distinctly regulating the two transporter-coding genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Isolation of a nitric oxide synthase from the protozoan parasite, Leishmania donovani.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Comparative analysis of the nitric oxide production by Leishmania sp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Leishmania tropica: regulation and specificity of the methionine transport system in promastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Active transport of glutamate in Leishmania (Leishmania) amazonensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Metabolic functions of glycosomes in trypanosomatids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

The biosynthetic incorporation of the intact leucine skeleton into sterol by the trypanosomatid Leishmania mexicana.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Highly specific methyl-end fatty-acid desaturases of trypanosomatids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

A versatile proline/alanine transporter in the unicellular pathogen Leishmania donovani regulates amino acid homoeostasis and osmotic stress responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Disruption of the lipid-transporting LdMT-LdRos3 complex in Leishmania donovani affects membrane lipid asymmetry but not host cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Intracellular growth and pathogenesis of Leishmania parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

The phagosome: compartment with a license to kill

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

CYP5122A1, a novel cytochrome P450 is essential for survival of Leishmania donovani

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Leishmania major lacking arginase (ARG) are auxotrophic for polyamines but retain infectivity to susceptible BALB/c mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Retooling Leishmania metabolism: from sand fly gut to human macrophage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Central carbon metabolism of Leishmania parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

Lysine transporters in human trypanosomatid pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-014-7772-1

10.1007/S00216-014-7772-1

21 January 2018

Identifiers

DOI

1 reference

26 December 2017

PubMed ID

24722876

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26 December 2017