CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses (Q36008355)

11 August 2017

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses (English)

1 reference

11 August 2017

5

1 reference

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31 May 2020

Hussein Al-Mossawi

8

1 reference

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31 May 2020

Jelle de Wit

9

1 reference

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31 May 2020

Matteo Vecellio

10

1 reference

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31 May 2020

Stefan Knapp

14

1 reference

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31 May 2020

Paul Bowness

15

1 reference

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31 May 2020

2

Cynthia Tallant

1 reference

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31 May 2020

12

Paul Wordsworth

1 reference

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31 May 2020

author name string

Ariane Hammitzsch

1

1 reference

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31 May 2020

Oleg Fedorov

3

1 reference

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31 May 2020

Alison O'Mahony

4

1 reference

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31 May 2020

Duncan A Hay

6

1 reference

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31 May 2020

Fernando O Martinez

7

1 reference

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31 May 2020

Christopher Wells

11

1 reference

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31 May 2020

Susanne Müller

13

1 reference

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31 May 2020

language of work or name

English

0 references

publication date

10 August 2015

1 reference

Proceedings of the National Academy of Sciences of the United States of America

11 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26261308%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

112

1 reference

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31 May 2020

issue

34

1 reference

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31 May 2020

page(s)

10768-10773

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26261308%20AND%20SRC:MED&resulttype=core&format=json

The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing

31 May 2020

cites work

1 reference

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Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

Targeting bromodomains: epigenetic readers of lysine acetylation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

2 October 2017

1 reference

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c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

2 October 2017

1 reference

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Global prevalence of ankylosing spondylitis

2 October 2017

1 reference

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BET bromodomain inhibition suppresses TH17-mediated pathology

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation

2 October 2017

1 reference

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Treatment challenges in axial spondylarthritis and future directions

2 October 2017

1 reference

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The epidemiology of back pain, axial spondyloarthritis and HLA-B27 in the United States

2 October 2017

1 reference

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Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

A validated regulatory network for Th17 cell specification

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

Small-molecule inhibition of BRDT for male contraception

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

Kinase inhibitor selectivity profiling using differential scanning fluorimetry

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

Bromodomains as therapeutic targets

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

An introduction to data reduction: space-group determination, scaling and intensity statistics

2 October 2017

1 reference

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Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

Suppression of inflammation by a synthetic histone mimic

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

Selective inhibition of BET bromodomains

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

2 October 2017

1 reference

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MolProbity: all-atom structure validation for macromolecular crystallography

2 October 2017

1 reference

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Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.

2 October 2017

1 reference

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Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells

2 October 2017

1 reference

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2 October 2017

1 reference

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Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7

2 October 2017

1 reference

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Phenotypic and functional features of human Th17 cells

2 October 2017

1 reference

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Identification of small-molecule antagonists that inhibit an activator: coactivator interaction

2 October 2017

1 reference

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Coot: model-building tools for molecular graphics

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

Refinement of macromolecular structures by the maximum-likelihood method

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

CREB-binding protein and p300 in transcriptional regulation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553799

Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites

2 October 2017

1 reference

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A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction

11 July 2018

1 reference

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Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial

23 September 2018

1 reference

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Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial.

23 September 2018

1 reference

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Chemical target and pathway toxicity mechanisms defined in primary human cell systems

23 September 2018

1 reference

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Mechanism of p300 specific histone acetyltransferase inhibition by small molecules

23 September 2018

1 reference

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Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes

23 September 2018

1 reference

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Analysis of gene expression and gene silencing in human macrophages.

23 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1501956112

Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26261308

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1501956112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26261308%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26261308%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference