Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice (Q36014510)

11 August 2017

Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice (English)

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11 August 2017

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Carol F Elias

6

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Robert T. Kennedy

object named as

Robert T Kennedy

9

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author name string

Tomoaki Morioka

1

1 reference

11 August 2017

Esra Asilmaz

2

1 reference

11 August 2017

Jiang Hu

3

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11 August 2017

John F Dishinger

4

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11 August 2017

Amarnath J Kurpad

5

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11 August 2017

Hui Li

7

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11 August 2017

Joel K Elmquist

8

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11 August 2017

Rohit N Kulkarni

10

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11 August 2017

language of work or name

English

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publication date

1 October 2007

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Journal of Clinical Investigation

11 August 2017

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11 August 2017

117

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11 August 2017

2860-2868

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11 August 2017

10

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describes a project that uses

11 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1994606/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance

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A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells

2 October 2017

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Expression of ghrelin receptor mRNA in the rat and the mouse brain

2 October 2017

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Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic beta-cells

2 October 2017

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Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes

2 October 2017

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Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

2 October 2017

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Leptin receptor signaling and the regulation of mammalian physiology

2 October 2017

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Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing

2 October 2017

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Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

2 October 2017

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Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity

2 October 2017

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Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

2 October 2017

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Selective deletion of leptin receptor in neurons leads to obesity

2 October 2017

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Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance

2 October 2017

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Selective interaction between leptin and insulin signaling pathways in a hepatic cell line

2 October 2017

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The adipoinsular axis: effects of leptin on pancreatic beta-cells

2 October 2017

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Regulation of fatty acid homeostasis in cells: novel role of leptin

2 October 2017

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Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice

2 October 2017

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Does leptin regulate insulin secretion?

2 October 2017

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Distributions of leptin receptor mRNA isoforms in the rat brain

2 October 2017

1 reference

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Disruption of IRS-2 causes type 2 diabetes in mice

2 October 2017

1 reference

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Divergent signaling capacities of the long and short isoforms of the leptin receptor

2 October 2017

1 reference

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Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice

2 October 2017

1 reference

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Rat insulinoma-derived pancreatic beta-cells express a functional leptin receptor that mediates a proliferative response.

2 October 2017

1 reference

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Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: evidence for a P13-kinase mediated effect

2 October 2017

1 reference

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Abnormal splicing of the leptin receptor in diabetic mice

2 October 2017

1 reference

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Alteration of Islet Cell Populations in Spontaneously Diabetic Mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1994606

The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1994606

Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1994606

Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1994606

Role of VEGF-A in vascularization of pancreatic islets

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1994606

Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1994606

beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1994606

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1994606

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1994606

Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1994606

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1994606

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1994606

Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice

23 September 2018

1 reference

12 December 2020

Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes

1 reference

12 December 2020

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

1 reference

12 December 2020

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes

1 reference

12 December 2020

Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI30910

1 reference

11 August 2017

1 reference

11 August 2017

1 reference