Molecular engineering of a secreted, highly homogeneous, and neurotoxic aβ dimer (Q36015420)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22778868%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

title

Molecular engineering of a secreted, highly homogeneous, and neurotoxic aβ dimer (English)

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7 February 2020

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3

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7 February 2020

author name string

Andreas Müller-Schiffmann

1

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7 February 2020

Aksana Andreyeva

2

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7 February 2020

Kurt Gottmann

4

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7 February 2020

Carsten Korth

5

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7 February 2020

Heinrich Sticht

6

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7 February 2020

publication date

11 March 2011

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ACS Chemical Neuroscience

7 February 2020

published in

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7 February 2020

volume

2

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7 February 2020

page(s)

242-248

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7 February 2020

issue

5

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Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering

7 February 2020

cites work

1 reference

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Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization

2 October 2017

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Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif

2 October 2017

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Despite its role in assembly, methionine 35 is not necessary for amyloid beta-protein toxicity

2 October 2017

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The metabolic enhancer piracetam ameliorates the impairment of mitochondrial function and neurite outgrowth induced by beta-amyloid peptide

2 October 2017

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Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production

2 October 2017

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Structural characterization of a soluble amyloid beta-peptide oligomer.

2 October 2017

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Role of methionine 35 in the intracellular Ca2+ homeostasis dysregulation and Ca2+-dependent apoptosis induced by amyloid beta-peptide in human neuroblastoma IMR32 cells

2 October 2017

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

2 October 2017

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

2 October 2017

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GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

2 October 2017

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

2 October 2017

1 reference

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Impact of the mutation A21G (Flemish variant) on Alzheimer's beta-amyloid dimers by molecular dynamics simulations

2 October 2017

1 reference

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A specific amyloid-beta protein assembly in the brain impairs memory

2 October 2017

1 reference

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3D structure of Alzheimer's amyloid-beta(1-42) fibrils

2 October 2017

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Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease

2 October 2017

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Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

2 October 2017

1 reference

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

2 October 2017

1 reference

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Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369749

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

2 October 2017

1 reference

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

2 October 2017

1 reference

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Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system.

2 October 2017

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Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

2 October 2017

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

2 October 2017

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Combining independent drug classes into superior, synergistically acting hybrid molecules.

2 October 2017

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A disulfide-linked amyloid-beta peptide dimer forms a protofibril-like oligomer through a distinct pathway from amyloid fibril formation

23 September 2018

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Amyloid-beta42 oligomer structures from fibrils: a systematic molecular dynamics study

23 September 2018

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gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.

23 September 2018

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The solvent protection of alzheimer amyloid-beta-(1-42) fibrils as determined by solution NMR spectroscopy.

23 September 2018

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Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation

23 September 2018

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Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

23 September 2018

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N-Cadherin Transsynaptically Regulates Short-Term Plasticity at Glutamatergic Synapses in Embryonic Stem Cell-Derived Neurons

23 September 2018

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Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

14 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22778868

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/CN200011H

1 reference

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7 February 2020

1 reference

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7 February 2020

1 reference

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