The promise of genetically engineered mice for cancer prevention studies (Q36058466)

11 August 2017

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title

The promise of genetically engineered mice for cancer prevention studies (English)

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11 August 2017

Jeffrey E Green

1

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PubMed ID

15738982

11 August 2017

Tamaro Hudson

series ordinal

2

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PubMed ID

15738982

11 August 2017

language of work or name

English

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publication date

1 March 2005

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11 August 2017

Nature Reviews Cancer

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11 August 2017

5

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11 August 2017

3

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11 August 2017

184-198

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https://scigraph.springernature.com/pub.10.1038/nrc1565

11 August 2017

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cites work

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21 January 2018

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21 January 2018

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Pathology of mouse models of intestinal cancer: consensus report and recommendations

21 January 2018

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Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer

21 January 2018

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Initiating oncogenic event determines gene-expression patterns of human breast cancer models

21 January 2018

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Myc-driven murine prostate cancer shares molecular features with human prostate tumors

21 January 2018

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Genetic background is an important determinant of metastatic potential.

21 January 2018

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Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

21 January 2018

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Gene expression profiling predicts clinical outcome of breast cancer

21 January 2018

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A gene-expression signature as a predictor of survival in breast cancer

21 January 2018

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Cancer resistance genes in mice: models for the study of tumour modifiers

21 January 2018

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Early cancer cell dissemination and late metastatic relapse: clinical reflections and biological approaches to the dormancy problem in patients

21 January 2018

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Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis

21 January 2018

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Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice

21 January 2018

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Chemoprevention of melanoma

21 January 2018

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PML-RARA-targeted DNA vaccine induces protective immunity in a mouse model of leukemia.

21 January 2018

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A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

21 January 2018

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Cancer genes and the pathways they control

21 January 2018

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Convergence of Wnt, beta-catenin, and cadherin pathways

21 January 2018

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Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

21 January 2018

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Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis.

21 January 2018

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Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

21 January 2018

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Prevention of gastrointestinal tumors based on adenomatous polyposis coli gene mutation by dendritic cell vaccine

21 January 2018

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Exercise and Intestinal Polyp Development in APCMin Mice

21 January 2018

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Plasma selenium levels and the risk of colorectal adenomas.

21 January 2018

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Chemoprevention of familial adenomatous polyposis development in the APC(min) mouse model by 1,4-phenylene bis(methylene)selenocyanate

21 January 2018

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Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2.

21 January 2018

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Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

21 January 2018

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Sulindac suppresses tumorigenesis in the Min mouse.

21 January 2018

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Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis

21 January 2018

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Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposis

21 January 2018

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Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms

21 January 2018

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Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis

21 January 2018

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Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

21 January 2018

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Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice

21 January 2018

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Smad3 mutant mice develop metastatic colorectal cancer

21 January 2018

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Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

21 January 2018

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Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

21 January 2018

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Chemosuppression of breast cancer with tamoxifen: laboratory evidence and future clinical investigations

21 January 2018

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The Effect of an Aromatase Inhibitor, 4-Hydroxy-4-Androstene- 3,17-Dione, On Estrogen-Dependent Processes in Reproduction and Breast Cancer11

21 January 2018

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Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis

21 January 2018

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Breast cancer: the protective effect of pregnancy

21 January 2018

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Combined allogeneic tumor cell vaccination and systemic interleukin 12 prevents mammary carcinogenesis in HER-2/neu transgenic mice

21 January 2018

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Insertion of the DNA for the 163-171 peptide of IL1beta enables a DNA vaccine encoding p185(neu) to inhibit mammary carcinogenesis in Her-2/neu transgenic BALB/c mice

21 January 2018

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Expansion of HER2/neu-specific T cells ex vivo following immunization with a HER2/neu peptide-based vaccine

21 January 2018

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Potential mouse tumor model for pre-clinical testing of mage-specific breast cancer vaccines.

21 January 2018

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HSP110-HER2/neu Chaperone Complex Vaccine Induces Protective Immunity Against Spontaneous Mammary Tumors in HER-2/neu Transgenic Mice

21 January 2018

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Concordant morphologic and gene expression data show that a vaccine halts HER-2/neu preneoplastic lesions

21 January 2018

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HER2-targeted therapy reduces incidence and progression of midlife mammary tumors in female murine mammary tumor virus huHER2-transgenic mice

21 January 2018

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Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor

21 January 2018

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Systemic gene therapy with anti-angiogenic factors inhibits spontaneous breast tumor growth and metastasis in MMTVneu transgenic mice

21 January 2018

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Prevention of HER-2/neu transgenic mammary carcinoma by tamoxifen plus interleukin 12.

21 January 2018

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Combined antiestrogen, antiangiogenic and anti-invasion therapy inhibits primary and metastatic tumor growth in the MMTVneu model of breast cancer.

21 January 2018

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Effect of epidermal growth factor receptor inhibitor on development of estrogen receptor-negative mammary tumors.

21 January 2018

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Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

21 January 2018

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Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

21 January 2018

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Cyclooxygenase-2: a potential target in breast cancer

21 January 2018

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Inhibition of VEGF receptors significantly impairs mammary cancer growth in C3(1)/Tag transgenic mice through antiangiogenic and non-antiangiogenic mechanisms

21 January 2018

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Chemoprevention of mammary carcinogenesis in a transgenic mouse model by alpha-difluoromethylornithine (DFMO) in the diet is associated with decreased cyclin D1 activity

21 January 2018

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Cancer prevention studies in p53-deficient mice

21 January 2018

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Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

21 January 2018

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Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

21 January 2018

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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

21 January 2018

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Genetically engineered mouse models for lung cancer.

21 January 2018

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An inducible melanoma model implicates a role for RAS in tumor maintenance and angiogenesis

21 January 2018

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Promising molecular targets for cancer prevention: AP-1, NF-kappa B and Pdcd4.

21 January 2018

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Patterns of protease production during prostate cancer progression: proteomic evidence for cascades in a transgenic model

21 January 2018

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Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

21 January 2018

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Targeted mutation of the Hprt gene in mouse embryonic stem cells

21 January 2018

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Altering the genome by homologous recombination

21 January 2018

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Recombineering: a powerful new tool for mouse functional genomics

21 January 2018

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Inducible gene targeting in mice using the Cre/lox system

21 January 2018

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Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice

21 January 2018

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Chemoprevention of spontaneous intestinal adenomas in the adenomatous polyposis coli Min mouse model with aspirin.

21 January 2018

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NO-donating aspirin inhibits intestinal carcinogenesis in Min (APC(Min/+)) mice

21 January 2018

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Prostate and mammary adenocarcinoma in transgenic mice carrying a rat C3(1) simian virus 40 large tumor antigen fusion gene

21 January 2018

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Comparative effects of lovastatin on mammary and prostate oncogenesis in transgenic mouse models

21 January 2018

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Inhibition of the mammary carcinoma angiogenic switch in C3(1)/SV40 transgenic mice by a mutated form of human endostatin.

21 January 2018

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21 January 2018

Cancer without disease.

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Chemoprevention of lung cancer in transgenic mice

21 January 2018

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Combinatorial chemoprevention of intestinal neoplasia

31 March 2020

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Effects of energy balance on cancer in genetically altered mice

31 March 2020

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A fish oil derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl ester suppresses the formation and growth of intestinal polyps in the Min mouse

31 March 2020

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Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice

31 March 2020

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APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse

31 March 2020

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The epidemiology of breast cancer

31 March 2020

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Changes associated with delay of mammary cancer by retinoid analogues in transgenic mice bearing c-neu oncogene.

31 March 2020

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Prevention of spontaneous breast carcinoma by prophylactic vaccination with dendritic/tumor fusion cells

31 March 2020

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Complete regression of established spontaneous mammary carcinoma and the therapeutic prevention of genetically programmed neoplastic transition by IL-12/pulse IL-2: induction of local T cell infiltration, Fas/Fas ligand gene expression, and mammary

31 March 2020

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Soy isoflavones increase latency of spontaneous mammary tumors in mice

31 March 2020

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Effect of melatonin and linolenic acid on mammary cancer in transgenic mice with c-neu breast cancer oncogene

31 March 2020

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Influence of diet on mammary cancer in transgenic mice bearing an oncogene expressed in mammary tissue

31 March 2020

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Dietary depletion of vitamin E and vitamin A inhibits mammary tumor growth and metastasis in transgenic mice

31 March 2020

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Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

31 March 2020

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Dietary soy sphingolipids suppress tumorigenesis and gene expression in 1,2-dimethylhydrazine-treated CF1 mice and ApcMin/+ mice

31 March 2020

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Selenium-enriched broccoli decreases intestinal tumorigenesis in multiple intestinal neoplasia mice

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1565

1 reference

11 August 2017

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PubMed ID

15738982