Modulating Molecular Chaperones Improves Mitochondrial Bioenergetics and Decreases the Inflammatory Transcriptome in Diabetic Sensory Neurons (Q36070681)

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English	Modulating Molecular Chaperones Improves Mitochondrial Bioenergetics and Decreases the Inflammatory Transcriptome in Diabetic Sensory Neurons	scientific article

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scholarly article

1 reference

Europe PubMed Central

12 August 2017

Modulating Molecular Chaperones Improves Mitochondrial Bioenergetics and Decreases the Inflammatory Transcriptome in Diabetic Sensory Neurons (English)

1 reference

Europe PubMed Central

12 August 2017

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molecular chaperones

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4

object named as

Brian S J Blagg

1 reference

Europe PubMed Central

12 August 2017

author name string

Jiacheng Ma

1

1 reference

Europe PubMed Central

12 August 2017

Pan Pan

2

1 reference

Europe PubMed Central

12 August 2017

Mercy Anyika

3

1 reference

Europe PubMed Central

12 August 2017

Rick T Dobrowsky

5

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Europe PubMed Central

12 August 2017

language of work or name

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based on heuristic

inferred from title

publication date

10 July 2015

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Europe PubMed Central

12 August 2017

ACS Chemical Neuroscience

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Europe PubMed Central

12 August 2017

6

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Europe PubMed Central

12 August 2017

1637-1648

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Europe PubMed Central

12 August 2017

9

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Europe PubMed Central

12 August 2017

The chaperone balance hypothesis: the importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management

1 reference

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2 October 2017

Moderate exercise training attenuates inflammatory mediators in DRG of Type 1 diabetic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

Hsp90 inhibition induces both protein-specific and global changes in the ubiquitinome.

1 reference

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2 October 2017

Inducible HSP70 is critical in preventing the aggregation and enhancing the processing of PMP22.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

BTBR ob/ob mice as a novel diabetic neuropathy model: Neurological characterization and gene expression analyses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

Mechanisms of diabetic neuron damage: Molecular pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

Combination therapies prevent the neuropathic, proinflammatory characteristics of bone marrow in streptozotocin-induced diabetic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

Hsp70 regulates immune response in experimental autoimmune encephalomyelitis

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2 October 2017

Diabetic neuropathy: mechanisms, emerging treatments, and subtypes

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2 October 2017

Energy crisis: the role of oxidative phosphorylation in acute inflammation and sepsis

1 reference

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2 October 2017

Decrease in neuroimmune activation by HSV-mediated gene transfer of TNFα soluble receptor alleviates pain in rats with diabetic neuropathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

HSF1 at a glance

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2 October 2017

A novel pulse-chase SILAC strategy measures changes in protein decay and synthesis rates induced by perturbation of proteostasis with an Hsp90 inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

Heat shock protein 70 is necessary to improve mitochondrial bioenergetics and reverse diabetic sensory neuropathy following KU-32 therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

Comprehensive evaluation of differential gene expression analysis methods for RNA-seq data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

Biology of diabetic neuropathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

2-phenylethynesulfonamide Prevents Induction of Pro-inflammatory Factors and Attenuates LPS-induced Liver Injury by Targeting NHE1-Hsp70 Complex in Mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

Loss of the inducible Hsp70 delays the inflammatory response to skeletal muscle injury and severely impairs muscle regeneration

1 reference

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2 October 2017

Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

Differential analysis of gene regulation at transcript resolution with RNA-seq

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2 October 2017

Decreased glycolytic and tricarboxylic acid cycle intermediates coincide with peripheral nervous system oxidative stress in a murine model of type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

Diabetic peripheral neuropathy: should a chaperone accompany our therapeutic approach?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

Evaluation of oxidative stress markers in pathogenesis of diabetic neuropathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

Synthesis and evaluation of novologues as C-terminal Hsp90 inhibitors with cytoprotective activity against sensory neuron glucotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

Enhanced glucose control for preventing and treating diabetic neuropathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

Diabetic neuropathy: clinical manifestations and current treatments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

TXNIP links innate host defense mechanisms to oxidative stress and inflammation in retinal Muller glia under chronic hyperglycemia: implications for diabetic retinopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

The role of aberrant mitochondrial bioenergetics in diabetic neuropathy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

C-terminal heat shock protein 90 inhibitor decreases hyperglycemia-induced oxidative stress and improves mitochondrial bioenergetics in sensory neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4573952

2 October 2017

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

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2 October 2017

The heat shock response: systems biology of proteotoxic stress in aging and disease

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2 October 2017

Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter?

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2 October 2017

IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030

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2 October 2017

The identification of gene expression profiles associated with progression of human diabetic neuropathy

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2 October 2017

Assessing mitochondrial dysfunction in cells.

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2 October 2017

Transcriptional profiling of diabetic neuropathy in the BKS db/db mouse: a model of type 2 diabetes.

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2 October 2017

Heat shock proteins protect against ischemia and inflammation through multiple mechanisms

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2 October 2017

Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats

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2 October 2017

Tolerating diabetes: an alternative therapeutic approach for diabetic neuropathy

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2 October 2017

Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in diabetic mice

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2 October 2017

Heat shock protein 70 (hsp70) as an emerging drug target.

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2 October 2017

Diet-induced obesity in two C57BL/6 substrains with intact or mutant nicotinamide nucleotide transhydrogenase (Nnt) gene

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2 October 2017

Caveolin-1 and altered neuregulin signaling contribute to the pathophysiological progression of diabetic peripheral neuropathy

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2 October 2017

Diabetes and the peripheral nerve

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2 October 2017

Mechanisms of disease: the oxidative stress theory of diabetic neuropathy

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2 October 2017

Diabetic neuropathy: mechanisms to management

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Hsp90 inhibition decreases mitochondrial protein turnover

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The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

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17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

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2 October 2017

Oxidative stress in the pathogenesis of diabetic neuropathy

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2 October 2017

Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein

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Hsp70 release from peripheral blood mononuclear cells.

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Effect of lifelong overexpression of HSP70 in skeletal muscle on age-related oxidative stress and adaptation after nondamaging contractile activity

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12 December 2020

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Role of inflammation in diabetic complications

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https://pubmed.ncbi.nlm.nih.gov/26161583

12 December 2020

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NADPH oxidase contributes directly to oxidative stress and apoptosis in nerve growth factor-deprived sympathetic neurons

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https://pubmed.ncbi.nlm.nih.gov/26161583

12 December 2020

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Increased susceptibility to ischemia and macrophage activation in STZ-diabetic rat nerve

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Soluble CD163 levels are elevated in cerebrospinal fluid and serum in people with Type 2 diabetes mellitus and are associated with impaired peripheral nerve function

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Identifiers

10.1021/ACSCHEMNEURO.5B00165

1 reference

Europe PubMed Central

12 August 2017

1 reference

Europe PubMed Central

12 August 2017

1 reference

Europe PubMed Central

12 August 2017

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