Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development. (Q36071656)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22513362%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development (English)

1 reference

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29 January 2020

14

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Kuang-Yu Jen

10

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29 January 2020

author name string

Yong-Won Kwon

1

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29 January 2020

Il-Jin Kim

2

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29 January 2020

Di Wu

3

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29 January 2020

Jing Lu

4

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29 January 2020

William A Stock

5

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29 January 2020

Yueyong Liu

6

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29 January 2020

Yurong Huang

7

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29 January 2020

Hio Chung Kang

8

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29 January 2020

Reyno DelRosario

9

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29 January 2020

Jesus Perez-Losada

11

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29 January 2020

Guangwei Wei

12

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29 January 2020

Allan Balmain

13

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29 January 2020

publication date

18 April 2012

1 reference

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Molecular Cancer Research

29 January 2020

published in

1 reference

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29 January 2020

volume

10

1 reference

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29 January 2020

issue

6

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29 January 2020

page(s)

834-844

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Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237

29 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Essential roles of mTOR/Akt pathway in Aurora-A cell transformation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

The aurora kinase A regulates GSK-3beta in gastric cancer cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

The Fbxw7/hCdc4 tumor suppressor in human cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Tenets of PTEN tumor suppression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Predictive value of Aurora-A/STK15 expression for late stage epithelial ovarian cancer patients treated by adjuvant chemotherapy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Roles of Aurora kinases in mitosis and tumorigenesis.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Genetic interactions between Pten and p53 in radiation-induced lymphoma development

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388112

Amplification/overexpression of a mitotic kinase gene in human bladder cancer

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22513362

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22513362

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/1541-7786.MCR-12-0025

1 reference

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29 January 2020

1 reference

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29 January 2020

1 reference

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