Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression (Q36073860)

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24 February 2020

title

Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression (English)

1 reference

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24 February 2020

0 references

1

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24 February 2020

10

Ilhong Son

1 reference

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24 February 2020

author name string

Hyejung Kim

2

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24 February 2020

Jisun Kim

3

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24 February 2020

Hyuna Sim

4

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24 February 2020

Hyunjun Ahn

5

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24 February 2020

Janghwan Kim

6

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24 February 2020

Hyemyung Seo

7

1 reference

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24 February 2020

Kwang Chul Chung

8

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24 February 2020

Bum-Joon Park

9

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24 February 2020

Wongi Seol

11

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24 February 2020

publication date

18 September 2015

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24 February 2020

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24 February 2020

volume

8

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24 February 2020

page(s)

54

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Creative Commons Attribution 4.0 International

24 February 2020

copyright license

start time

18 September 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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LRRK2 phosphorylates novel tau epitopes and promotes tauopathy

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Dexamethasone induces the expression of LRRK2 and α-synuclein, two genes that when mutated cause Parkinson's disease in an autosomal dominant manner.

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S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease

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LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25

2 October 2017

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LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

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Phosphorylation of LRRK2: from kinase to substrate

2 October 2017

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Impaired inflammatory responses in murine Lrrk2-knockdown brain microglia

2 October 2017

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ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2

2 October 2017

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GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1

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Parkinson's disease and cancer: two wars, one front

2 October 2017

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Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

2 October 2017

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Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death

2 October 2017

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LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations

2 October 2017

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2 October 2017

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Identification of chemicals to inhibit the kinase activity of leucine-rich repeat kinase 2 (LRRK2), a Parkinson's disease-associated protein

2 October 2017

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2 October 2017

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2 October 2017

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Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells

2 October 2017

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Biochemical and molecular features of LRRK2 and its pathophysiological roles in Parkinson's disease

2 October 2017

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Parkinson's disease and cancer risk: a systematic review and meta-analysis

2 October 2017

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Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.

2 October 2017

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LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans

2 October 2017

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Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?

2 October 2017

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The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

2 October 2017

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Cytoskeleton-associated proteins are enriched in human embryonic-stem cell-derived neuroectodermal spheres

2 October 2017

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Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

2 October 2017

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LRRK2 regulates synaptic vesicle endocytosis

2 October 2017

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Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

2 October 2017

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

2 October 2017

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Apoptotic mechanisms in mutant LRRK2-mediated cell death

2 October 2017

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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

2 October 2017

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

2 October 2017

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Kinase activity of mutant LRRK2 mediates neuronal toxicity

2 October 2017

1 reference

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Posttranslational phosphorylation of mutant p53 protein in tumor development

2 October 2017

1 reference

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

2 October 2017

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Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson's disease

2 October 2017

1 reference

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

2 October 2017

1 reference

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p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.

2 October 2017

1 reference

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

2 October 2017

1 reference

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575451

Dynamics in the p53-Mdm2 ubiquitination pathway

2 October 2017

1 reference

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p53 mediates DNA damaging drug-induced apoptosis through a caspase-9-dependent pathway in SH-SY5Y neuroblastoma cells.

2 October 2017

1 reference

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Regulation of p53 localization

2 October 2017

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Twenty years of p53 research: structural and functional aspects of the p53 protein

2 October 2017

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A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl-terminal domain

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575451

Differential subcellular p53 localization and function in N- and S-type neuroblastoma cell lines

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575451

Regulation of the p53 protein by protein kinase C alpha and protein kinase C zeta

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575451

The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro

2 October 2017

1 reference

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Determination of the specific substrate sequence motifs of protein kinase C isozymes

2 October 2017

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The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells

2 October 2017

1 reference

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WAF1, a potential mediator of p53 tumor suppression

2 October 2017

1 reference

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SOX4 overexpression regulates the p53-mediated apoptosis in hepatocellular carcinoma: clinical implication and functional analysis in vitro.

2 October 2017

1 reference

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Repression of rRNA transcription by PARIS contributes to Parkinson's disease

11 July 2018

1 reference

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LRRK2-G2019S mutation is not associated with an increased cancer risk: a kin-cohort study.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575451

Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575451

p38(MAPK)/p53-Mediated Bax induction contributes to neurons degeneration in rotenone-induced cellular and rat models of Parkinson's disease

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575451

LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575451

p53 protein, interferon-gamma, and NF-kappaB levels are elevated in the parkinsonian brain

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575451

A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations

23 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2FS13041-015-0145-7

The in vitro phosphorylation of p53 by calcium-dependent protein kinase C--characterization of a protein-kinase-C-binding site on p53

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26384650

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mortality and cancer incidence in patients with Parkinson's disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26384650

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Wild-type p53 can induce p21 and apoptosis in neuroblastoma cells but the DNA damage-induced G1 checkpoint function is attenuated

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26384650

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/S13041-015-0145-7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26384650%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

24 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26384650%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

26384650

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26384650%20AND%20SRC:MED&resulttype=core&format=json