Posttranslational phosphorylation of mutant p53 protein in tumor development (Q36527456)

14 August 2017

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title

Posttranslational phosphorylation of mutant p53 protein in tumor development (English)

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14 August 2017

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Manabu Matsumoto

1

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PubMed ID

16821145

14 August 2017

Mutsuo Furihata

series ordinal

2

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PubMed ID

16821145

14 August 2017

Yuji Ohtsuki

series ordinal

3

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14 August 2017

1 June 2006

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Medical Molecular Morphology

14 August 2017

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14 August 2017

39

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14 August 2017

2

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14 August 2017

79-87

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https://scigraph.springernature.com/pub.10.1007/s00795-006-0320-0

14 August 2017

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cites work

Regulation of p53 function and stability by phosphorylation

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https://api.crossref.org/works/10.1007%2FS00795-006-0320-0

Mapping of the p53 and mdm-2 interaction domains

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00795-006-0320-0

The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00795-006-0320-0

Analysis of a protein-binding domain of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00795-006-0320-0

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00795-006-0320-0

The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00795-006-0320-0

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00795-006-0320-0

p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00795-006-0320-0

Multi-site phosphorylation of p53 by protein kinases inducible by p53 and DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00795-006-0320-0

Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00795-006-0320-0

Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage

21 January 2018

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12 December 2020

Domain architecture of the p62 subunit from the human transcription/repair factor TFIIH deduced by limited proteolysis and mass spectrometry analysis.

1 reference

12 December 2020

Direct interaction of p21 cyclin-dependent kinase inhibitor with the retinoblastoma tumor suppressor protein

1 reference

12 December 2020

TP53 tumor suppressor gene: a model for investigating human mutagenesis

1 reference

12 December 2020

Two distinct regions of the murine p53 primary amino acid sequence are implicated in stable complex formation with simian virus 40 T antigen.

1 reference

12 December 2020

Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene

1 reference

12 December 2020

Identification of a p53-dependent negative response element in the bcl-2 gene

1 reference

12 December 2020

Cell cycle checkpoint signaling through the ATM and ATR kinases

1 reference

12 December 2020

Localization of gene for human p53 tumour antigen to band 17p13.

1 reference

12 December 2020

Oxygen(es) and the hypoxia-inducible factor-1.

1 reference

12 December 2020

Regulation of p53 downstream genes.

1 reference

12 December 2020

The aberrant p53 protein (review).

1 reference

12 December 2020

Phosphorylation of T antigen and p53 in carcinogen-treated SV40-transformed Chinese hamster cells

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12 December 2020

High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation.

1 reference

12 December 2020

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

1 reference

12 December 2020

Gain of function mutations in p53.

1 reference

12 December 2020

Frequent phosphorylation at serine 392 in overexpressed p53 protein due to missense mutation in carcinoma of the urinary tract

1 reference

12 December 2020

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

12 December 2020

Two cellular proteins that bind to wild-type but not mutant p53

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12 December 2020

Signaling to p53: breaking the MDM2-p53 circuit

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12 December 2020

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12 December 2020

The p53 tumour suppressor gene

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12 December 2020

Wild-type p53 binds to the TATA-binding protein and represses transcription

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12 December 2020

Ser392 phosphorylation regulates the oncogenic function of mutant p53.

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12 December 2020

A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1

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12 December 2020

The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth

1 reference

12 December 2020

Wild-type human p53 activates the human epidermal growth factor receptor promoter

1 reference

12 December 2020

Human p53 gene localized to short arm of chromosome 17

1 reference

12 December 2020

Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

1 reference

12 December 2020

Post-translational modification of p53 in tumorigenesis

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12 December 2020

Mutation of phosphoserine 389 affects p53 function in vivo

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12 December 2020

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

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12 December 2020

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

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12 December 2020

p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389.

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12 December 2020

Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein

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12 December 2020

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

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12 December 2020

Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus

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12 December 2020

How p53 binds DNA as a tetramer

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12 December 2020

p53 Phosphorylation: biochemical and functional consequences

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12 December 2020

Wild-type p53 negatively regulates the expression of a microtubule-associated protein

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12 December 2020

The p53 protein is an unusually shaped tetramer that binds directly to DNA.

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12 December 2020

p53 is required for radiation-induced apoptosis in mouse thymocytes

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12 December 2020

WAF1, a potential mediator of p53 tumor suppression

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12 December 2020

The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13)

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12 December 2020

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

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12 December 2020

DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

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12 December 2020

A direct effect of activated human p53 on nuclear DNA replication

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12 December 2020

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

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12 December 2020

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

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12 December 2020

Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53

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12 December 2020

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2

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12 December 2020

p53, the cellular gatekeeper for growth and division

1 reference

12 December 2020

The complexity of p53 modulation: emerging patterns from divergent signals

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12 December 2020

Presence of a potent transcription activating sequence in the p53 protein

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12 December 2020

Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation

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12 December 2020

Small peptides activate the latent sequence-specific DNA binding function of p53.

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12 December 2020

Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation

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12 December 2020

Gain-of-function mutations in the tumor suppressor gene p53.

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12 December 2020

Post-translational modifications and activation of p53 by genotoxic stresses

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12 December 2020

p53 mutations in human cancers

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12 December 2020

Decision making by p53: life, death and cancer

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12 December 2020

Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription

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12 December 2020

Regulation of the specific DNA binding function of p53

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12 December 2020

Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases

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12 December 2020

p53 protein expression and prognosis in squamous cell carcinoma of the esophagus

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12 December 2020

p53 and E2F-1 cooperate to mediate apoptosis

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12 December 2020

Conformation-dependent phosphorylation of p53.

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12 December 2020

The p53-mdm-2 autoregulatory feedback loop

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12 December 2020

Definition of a consensus binding site for p53

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12 December 2020

Sequence-specific transcriptional activation is essential for growth suppression by p53.

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12 December 2020

Regulation of p53 responses by post-translational modifications

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12 December 2020

Two distinct signaling pathways activate the latent DNA binding function of p53 in a casein kinase II-independent manner.

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12 December 2020

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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12 December 2020

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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12 December 2020

Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

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12 December 2020

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

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12 December 2020

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

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12 December 2020

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

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12 December 2020

Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants

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12 December 2020

Twenty years of p53 research: structural and functional aspects of the p53 protein

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12 December 2020

'Gain of function' phenotype of tumor-derived mutant p53 requires the oligomerization/nonsequence-specific nucleic acid-binding domain

1 reference

12 December 2020

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

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12 December 2020

The carboxy-terminal serine 392 phosphorylation site of human p53 is not required for wild-type activities.

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12 December 2020

No prognostic significance of p53 expression in esophageal squamous cell carcinoma

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12 December 2020

Recruitment of p300/CBP in p53-dependent signal pathways

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12 December 2020

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

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12 December 2020

Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells

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12 December 2020

Phosphorylation of human p53 on Thr-55.

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12 December 2020

Phosphorylation state of tumor-suppressor gene p53 product overexpressed in skin tumors.

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12 December 2020

Mutant p53 is constitutively phosphorylated at Serine 15 in UV-induced mouse skin tumors: involvement of ERK1/2 MAP kinase

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12 December 2020

p53: puzzle and paradigm

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12 December 2020

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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12 December 2020

Murine p53 is phosphorylated within the PAb421 epitope by protein kinase C in vitro, but not in vivo, even after stimulation with the phorbol ester o-tetradecanoylphorbol 13-acetate

1 reference

12 December 2020

The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association

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12 December 2020

Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents

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12 December 2020

Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein

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12 December 2020

Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15

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12 December 2020

Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53

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12 December 2020

Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin

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12 December 2020

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

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12 December 2020

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

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12 December 2020

Distinct pattern of p53 phosphorylation in human tumors

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12 December 2020

Post-translational modification of p53.

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12 December 2020

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12 December 2020

Transcriptional activation by p53 correlates with suppression of growth but not transformation.

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12 December 2020

Physical and functional interaction between WT1 and p53 proteins

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12 December 2020

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.

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12 December 2020

p53 phosphorylation and association with murine double minute 2, c-Jun NH2-terminal kinase, p14ARF, and p300/CBP during the cell cycle and after exposure to ultraviolet irradiation

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12 December 2020

Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression

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12 December 2020

Inhibition of DNA replication factor RPA by p53.

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12 December 2020

Structural aspects of the p53 protein in relation to gene evolution

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12 December 2020

CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein

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12 December 2020

Identification of p53 as a sequence-specific DNA-binding protein

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12 December 2020

The transactivator proteins VP16 and GAL4 bind replication factor A.

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12 December 2020

The polyproline region of p53 is required to activate apoptosis but not growth arrest.

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12 December 2020

Dissociation of DNA binding and in vitro transcriptional activities dependent on the C terminus of P53 proteins

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12 December 2020

Prognostic significance of serine 392 phosphorylation in overexpressed p53 protein in human esophageal squamous cell carcinoma

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12 December 2020

Role of preoperative chemoradiation in the management of upper third thoracic esophageal squamous cell carcinoma

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12 December 2020

Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

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12 December 2020

Oligomerization of oncoprotein p53.

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12 December 2020

Functional inactivation of genes by dominant negative mutations

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12 December 2020

10.1007/S00795-006-0320-0

Identifiers

DOI

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14 August 2017

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PubMed ID

16821145