A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis (Q36080701)

12 August 2017

A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis (English)

1 reference

12 August 2017

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Wenjun Ouyang

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Cathy Tournier

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Ling Wu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Xing Chen

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Junjie Zhao

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Jarod A Zepp

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Jennifer S Ko

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Chunfang Gu

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Gang Cai

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Ganes Sen

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

George R Stark

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Bing Su

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Charlotte M Vines

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Thomas A Hamilton

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Allison Vidimos

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Brian Gastman

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Caini Liu

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Xiaoxia Li

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

language of work or name

English

0 references

publication date

7 September 2015

1 reference

Journal of Experimental Medicine

12 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

212

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

1571-1587

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis.

1 June 2020

cites work

1 reference

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Structure of the unique SEFIR domain from human interleukin 17 receptor A reveals a composite ligand-binding site containing a conserved α-helix for Act1 binding and IL-17 signaling

2 October 2017

1 reference

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ERKs in cancer: friends or foes?

2 October 2017

1 reference

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Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality.

2 October 2017

1 reference

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The Crystal Structure of Six-transmembrane Epithelial Antigen of the Prostate 4 (Steap4), a Ferri/Cuprireductase, Suggests a Novel Interdomain Flavin-binding Site

2 October 2017

1 reference

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IL-17 in psoriasis: implications for therapy and cardiovascular co-morbidities

2 October 2017

1 reference

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Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression.

2 October 2017

1 reference

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The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90.

2 October 2017

1 reference

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Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

2 October 2017

1 reference

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Forced expression of miR-143 represses ERK5/c-Myc and p68/p72 signaling in concert with miR-145 in gut tumors of Apc(Min) mice

2 October 2017

1 reference

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ERK5: structure, regulation and function.

2 October 2017

1 reference

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Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Cutting edge: TNF receptor-associated factor 4 restricts IL-17-mediated pathology and signaling processes

2 October 2017

1 reference

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Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy

2 October 2017

1 reference

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STEAP proteins: from structure to applications in cancer therapy.

2 October 2017

1 reference

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A protective role by interleukin-17F in colon tumorigenesis

2 October 2017

1 reference

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IL-17 mediated inflammation promotes tumor growth and progression in the skin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

MEK5/ERK5 pathway: the first fifteen years

2 October 2017

1 reference

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Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF)

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Th17 cells in cancer: help or hindrance?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

IL-17 enhances tumor development in carcinogen-induced skin cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Regulation of hepatic six transmembrane epithelial antigen of prostate 4 (STEAP4) expression by STAT3 and CCAAT/enhancer-binding protein alpha

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis

2 October 2017

1 reference

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Structure and signalling in the IL-17 receptor family

2 October 2017

1 reference

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MEKK3 is essential for lymphopenia-induced T cell proliferation and survival.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

The roles of IL-17A in inflammatory immune responses and host defense against pathogens

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Identification of pharmacological inhibitors of the MEK5/ERK5 pathway

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

A skin microRNA promotes differentiation by repressing 'stemness'.

2 October 2017

1 reference

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Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

2 October 2017

1 reference

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TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

p63 and p73 in human cancer: defining the network

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

ERK5 activation inhibits inflammatory responses via peroxisome proliferator-activated receptor delta (PPARdelta) stimulation.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Cutting edge: interleukin 17 signals through a heteromeric receptor complex

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

IL-23 promotes tumour incidence and growth

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Act1, a negative regulator in CD40- and BAFF-mediated B cell survival

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Role of the adaptor protein CIKS in the activation of the IKK complex

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

2 October 2017

Inflammation and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

IL-17 signaling for mRNA stabilization does not require TNF receptor-associated factor 6

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

ERK5 is a critical mediator of inflammation-driven cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Role of IL-17A in the development of colitis-associated cancer.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Regulation of neuronal survival by the extracellular signal-regulated protein kinase 5.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Perp is a p63-regulated gene essential for epithelial integrity.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

Activation of cyclin D1 expression by the ERK5 cascade

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4577838

TRAF4 overexpression is a common characteristic of human carcinomas

23 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20150204

Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26347473

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Interleukin-17 promotes angiogenesis and tumor growth

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26347473

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

IL-6 increases primed cell expansion and survival

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26347473

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20150204

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26347473%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

26347473

1 reference