Preclinical analysis of the γ-secretase inhibitor PF-03084014 in combination with glucocorticoids in T-cell acute lymphoblastic leukemia (Q36084159)

12 August 2017

Preclinical analysis of the γ-secretase inhibitor PF-03084014 in combination with glucocorticoids in T-cell acute lymphoblastic leukemia (English)

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12 August 2017

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lymphoblastic leukemia

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T-cell acute lymphoblastic leukemia

inferred from title

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11

Carlos Cordon-Cardo

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12 August 2017

5

Elisabeth Paietta

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12 August 2017

7

Peter H Wiernik

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12 August 2017

3

Michael Hadler

1 reference

12 August 2017

Mireia Castillo-Martin

2

object named as

Mireia Castillo-Martin

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12 August 2017

12

Adolfo A Ferrando

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12 August 2017

Jeremy B Samon

1

1 reference

12 August 2017

Alberto Ambesi-Impiobato

4

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12 August 2017

Janis Racevskis

6

1 reference

12 August 2017

Jacob M Rowe

8

1 reference

12 August 2017

John Jakubczak

9

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12 August 2017

Sophia Randolph

10

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12 August 2017

13 April 2012

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Molecular Cancer Therapeutics

12 August 2017

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12 August 2017

11

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7

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12 August 2017

1565-1575

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describes a project that uses

12 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3392513/fullTextXML

inferred from PubMed Central ID database lookup

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design

2 October 2017

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2 October 2017

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Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014.

2 October 2017

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2 October 2017

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Direct inhibition of the NOTCH transcription factor complex

2 October 2017

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DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity

2 October 2017

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NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia.

2 October 2017

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Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer

2 October 2017

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Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

2 October 2017

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Targeting the Notch1 and mTOR pathways in a mouse T-ALL model

2 October 2017

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KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract

2 October 2017

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Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

2 October 2017

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NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity

2 October 2017

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In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia.

2 October 2017

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Notch signaling in leukemia

2 October 2017

1 reference

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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

2 October 2017

1 reference

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The glucocorticoid responses are shaped by molecular chaperones

2 October 2017

1 reference

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Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia

2 October 2017

1 reference

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Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias.

2 October 2017

1 reference

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Notch signalling: a simple pathway becomes complex

2 October 2017

1 reference

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CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitors

2 October 2017

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A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

2 October 2017

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Aberrant activation of notch signaling in human breast cancer

2 October 2017

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Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

2 October 2017

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Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation

2 October 2017

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

2 October 2017

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2 October 2017

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Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia

2 October 2017

1 reference

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In vitro cellular drug resistance in children with relapsed/refractory acute lymphoblastic leukemia

2 October 2017

1 reference

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23 September 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/22504949

12 December 2020

inferred from PubMed ID database lookup

In vitro drug sensitivity testing can predict induction failure and early relapse of childhood acute lymphoblastic leukemia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22504949

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1158/1535-7163.MCT-11-0938

1 reference

12 August 2017

1 reference

12 August 2017

1 reference