Role of cytochrome P450 activity in the fate of anticancer agents and in drug resistance: focus on tamoxifen, paclitaxel and imatinib metabolism (Q36097229)

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English	Role of cytochrome P450 activity in the fate of anticancer agents and in drug resistance: focus on tamoxifen, paclitaxel and imatinib metabolism	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

1 reference

Europe PubMed Central

Role of cytochrome P450 activity in the fate of anticancer agents and in drug resistance: focus on tamoxifen, paclitaxel and imatinib metabolism (English)

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

drug resistance

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based on heuristic

inferred from title

author name string

Bertrand Rochat

1

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 January 2005

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

Clinical Pharmacokinetics

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Europe PubMed Central

PubMed publication ID

12 August 2017

44

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

349-366

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

Paclitaxel resistance in non-small-cell lung cancer associated with beta-tubulin gene mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 gene-directed enzyme prodrug therapy (GDEPT) for cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and pharmacological aspects of antiestrogen resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variability in human cytochrome P450 paclitaxel metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of probe drugs as predictors of drug metabolism in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcr-Abl inhibition as a modality of CML therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that the catechol 3,4-Dihydroxytamoxifen is a proximate intermediate to the reactive species binding covalently to proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the mechanism of action of the nonsteroidal antioestrogen tamoxifen (I.C.I. 46,474) in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic basis of drug metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Individualized cancer therapy: molecular approaches to the prediction of tumor response

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morning spot and 24-hour urinary 6 beta-hydroxycortisol to cortisol ratios: intraindividual variability and correlation under basal conditions and conditions of CYP 3A4 induction

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic contribution to variable human CYP3A-mediated metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P-450-mediated activation and irreversible binding of the antiestrogen tamoxifen to proteins in rat and human liver: possible involvement of flavin-containing monooxygenases in tamoxifen activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical relevance of genetic polymorphisms in the human CYP2C subfamily

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer therapy and polymorphisms of cytochromes P450.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New-age drug meets resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The erythromycin breath test for the prediction of drug clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of cytochrome P450 inducers on tamoxifen genotoxicity in female mice in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenomic analysis of cytogenetic response in chronic myeloid leukemia patients treated with imatinib

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imatinib mesylate resistance through BCR-ABL independence in chronic myelogenous leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transport and binding of taxol

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species differences in the covalent binding of [14C]tamoxifen to liver microsomes and the forms of cytochrome P450 involved

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase I/II trial of paclitaxel for non-Hodgkin's lymphoma followed by paclitaxel plus quinine in drug-resistant disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical localization and semi-quantitation of hepatic tamoxifen-DNA adducts in rats exposed orally to tamoxifen

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of dietary broccoli on human drug metabolising activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenetics of anticancer agents: lessons from amonafide and irinotecan.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High incidence of BCR-ABL kinase domain mutations and absence of mutations of the PDGFR and KIT activation loops in CML patients with secondary resistance to imatinib

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative in vitro cytotoxic effects of taxol and its major human metabolite 6 alpha-hydroxytaxol

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biotransformation of tamoxifen in a human endometrial explant culture model

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences between in vivo and in vitro sensitivity to imatinib of Bcr/Abl+ cells obtained from leukemic patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a taxol-resistant human small-cell lung cancer cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of human CYP forms involved in the activation of tamoxifen and irreversible binding to DNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha1 acid glycoprotein binds to imatinib (STI571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How to manage individualized drug therapy: application of pharmacogenetic knowledge of drug metabolism and transport.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation between docetaxel clearance and estimated cytochrome P450 activity by urinary metabolite of exogenous cortisol

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human CYP1B1 and anticancer agent metabolism: mechanism for tumor-specific drug inactivation?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acquired resistance to imatinib mesylate: selection for pre-existing mutant cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of response to docetaxel by CYP3A4 mRNA expression in breast cancer tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation, structural determination, and biological activity of 6 alpha-hydroxytaxol, the principal human metabolite of taxol

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic fluvoxamine-clomipramine interaction with favorable therapeutic consequences in therapy-resistant depressive patient

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of tamoxifen feeding on metabolic activation of tamoxifen by the liver of the rhesus monkey: does liver accumulation of inhibitory metabolites protect from tamoxifen-dependent genotoxicity and cancer?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes associated with the development of resistance to imatinib (STI571) in two leukemia cell lines expressing p210 Bcr/Abl protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Levels of multidrug resistance (MDR1) P-glycoprotein expression by human breast cancer correlate with in vitro resistance to taxol and doxorubicin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of cytochrome P450 activity by a five-drug cocktail approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Taxanes in adjuvant and neoadjuvant therapies for breast cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validation of a therapeutic drug monitoring strategy for thiotepa in a high-dose chemotherapy regimen.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-expression of several molecular mechanisms of multidrug resistance and their significance for paclitaxel cytotoxicity in human AML HL-60 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary breast tumor levels of suspected molecular determinants of cellular sensitivity to cyclophosphamide, ifosfamide, and certain other anticancer agents as predictors of paired metastatic tumor levels of these determinants. Rational individualiz

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative analysis of constitutive and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cytochrome P450 1B1 expression in human lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extrahepatic metabolism of drugs in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenomics

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenetics: a tool for individualizing antineoplastic therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The importance of tamoxifen metabolism in tamoxifen-stimulated breast tumor growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biomonitoring of urinary tamoxifen and its metabolites from breast cancer patients using nonaqueous capillary electrophoresis with electrospray mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic activation of 2-acetylaminofluorene is required for induction of multidrug resistance gene expression in rat liver cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roots of clinical resistance to STI-571 cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of resistance to STI571 in Philadelphia chromosome-associated leukemias

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450-based cancer gene therapy: current status

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction and characterization of taxol-resistance phenotypes with a transiently expressed artificial transcriptional activator library

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the cytochrome P450 involved in side-chain oxidation of cyclophosphamide in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P-450 3A4: regulation and role in drug metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic activation of toxins: tissue-specific expression and metabolism in target organs

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imatinib mesylate--a new oral targeted therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coinduction of MDR-1 multidrug-resistance and cytochrome P-450 genes in rat liver by xenobiotics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenetics and cancer chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characterization and sensitivity of STI-571 (imatinib mesylate, Gleevec)-resistant, Bcr-Abl-positive, human acute leukemia cells to SRC kinase inhibitor PD180970 and 17-allylamino-17-demethoxygeldanamycin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

No ethnic difference between Caucasian and Japanese hepatic samples in the expression frequency of CYP3A5 and CYP3A7 proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interindividual variation in the isomerization of 4-hydroxytamoxifen by human liver microsomes: involvement of cytochromes P450.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinases as targets for anticancer agents: from inhibitors to useful drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of both p185c-erbB2 and p170mdr-1 renders breast cancer cells highly resistant to taxol

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessing the cost-effectiveness of pharmacogenomics

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced clearance of topoisomerase I inhibitors from human colon cancer cells by glucuronidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and induction of CYP4F subfamily in human leukocytes and HL60 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin A does not reverse clinical resistance to paclitaxel in patients with relapsed non-Hodgkin's lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of paclitaxel metabolism in a cancer patient by induction of cytochrome P450 3A4

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of alpha-1 acid glycoprotein in patients with Ph+ chronic myeloid leukemia during the first 13 weeks of therapy with STI571.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Understanding the genotoxicity of tamoxifen?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of an individual's cytochrome CYP3A4 activity on docetaxel clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Making TDM work to optimize cancer chemotherapy: a multidisciplinary team approach.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Taxol metabolism by human liver microsomes: identification of cytochrome P450 isozymes involved in its biotransformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucuronidation as a mechanism of intrinsic drug resistance in colon cancer cells: contribution of drug transport proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of resistance to imatinib (STI571) and prospects for combination with conventional chemotherapeutic agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genotyping and phenotyping the cytochrome p-450 enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenetics as a molecular basis for individualized drug therapy: the thiopurine S-methyltransferase paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between elevated levels of the alpha 1 acid glycoprotein in chronic myelogenous leukemia in blast crisis and pharmacological resistance to imatinib (Gleevec) in vitro and in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of P-glycoprotein and cytochrome P450 3A by HIV protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human cytochrome P450 (CYP) genes: recommendations for the nomenclature of alleles

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity of drug resistance in human breast and ovarian cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 1B1: a major P450 isoenzyme in human blood monocytes and macrophage subsets

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concentrations of tamoxifen and its major metabolites in hormone responsive and resistant breast tumours

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species-specific differences in taxol transport and cytotoxicity against human and rodent tumor cells. Evidence for an alternate transport system

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Cyp1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of alpha1 acid glycoprotein in the in vivo resistance of human BCR-ABL(+) leukemic cells to the abl inhibitor STI571

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenetics and cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms of genetic polymorphisms of drug metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunochemical analysis of Cytochrome P450 variability in human leukapheresed samples and its consequences for the risk assessment process

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P450 enzyme expression patterns in the NCI human tumor cell line panel

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative gene expression profile of chronic myeloid leukemia cells innately resistant to imatinib mesylate

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of tamoxifen metabolites in human Hep G2 cell line, human liver homogenate, and patients on long-term therapy for breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human cytochrome P-450 (CYP) genes: a web page for the nomenclature of alleles

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenetic diagnostics of cytochrome P450 polymorphisms in clinical drug development and in drug treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor-specific expression of cytochrome P450 CYP1B1

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intra-individual variation and sex differences in gene expression of cytochromes P450 in circulating leukocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated Bcr-Abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 CYP1B1 protein expression: a novel mechanism of anticancer drug resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinically relevant drug-drug interactions in oncology

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrarapid metabolism of clomipramine in a therapy-resistant depressive patient, as confirmed by CYP2 D6 genotyping.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumoral drug metabolism: perspectives and therapeutic implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STI571: a magic bullet?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug interactions in oncology

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of recombinant cytochromes P450 activity in metabolic pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Major inter-species differences in the rates of O-sulphonation and O-glucuronylation of alpha-hydroxytamoxifen in vitro: a metabolic disparity protecting human liver from the formation of tamoxifen-DNA adducts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional polymorphisms of the human multidrug resistance (MDR1) gene: correlation with P glycoprotein expression and activity in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vertebrate UDP-glucuronosyltransferases: functional and evolutionary aspects

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidation of cyclophosphamide to 4-hydroxycyclophosphamide and deschloroethylcyclophosphamide in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STI571: an inhibitor of the BCR-ABL tyrosine kinase for the treatment of chronic myelogenous leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acquisition of taxol resistance via P-glycoprotein- and non-P-glycoprotein-mediated mechanisms in human ovarian carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15828850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/00003088-200544040-00002

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 August 2017

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