Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40. (Q35790354)

10 August 2017

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title

Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40. (English)

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10 August 2017

Kazuo Sugamura

1

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10 August 2017

Naoto Ishii

series ordinal

2

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10 August 2017

Andrew D Weinberg

series ordinal

3

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10 August 2017

publication date

1 June 2004

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Nature Reviews Immunology

10 August 2017

published in

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10 August 2017

volume

4

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10 August 2017

issue

6

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10 August 2017

page(s)

420-431

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Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts

10 August 2017

cites work

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Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax

21 January 2018

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Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

21 January 2018

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Expression of gp34 (OX40 ligand) and OX40 on human T cell clones

21 January 2018

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Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions

21 January 2018

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Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand

21 January 2018

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The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion.

21 January 2018

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OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells

21 January 2018

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Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis

21 January 2018

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CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice.

21 January 2018

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Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases.

21 January 2018

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OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation

21 January 2018

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A critical role for OX40 in T cell-mediated immunopathology during lung viral infection

21 January 2018

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OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice

21 January 2018

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Critical role of OX40 in CD28 and CD154-independent rejection.

21 January 2018

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The role of the CD134-CD134 ligand costimulatory pathway in alloimmune responses in vivo

21 January 2018

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OX40 (CD134) and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses.

21 January 2018

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T cell co-stimulatory molecules other than CD28.

21 January 2018

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The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function

21 January 2018

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Signals and signs for lymphocyte responses

21 January 2018

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CD28/B7 system of T cell costimulation

21 January 2018

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21 January 2018

The B7-CD28 superfamily

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Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

21 January 2018

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Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo

21 January 2018

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CD27 Promotes Survival of Activated T Cells and Complements CD28 in Generation and Establishment of the Effector T Cell Pool

21 January 2018

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The costimulation-regulated duration of PKB activation controls T cell longevity

21 January 2018

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OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection

21 January 2018

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Functional responses and costimulator dependence of memory CD4+ T cells.

21 January 2018

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CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells.

21 January 2018

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Antibody therapy for rheumatoid arthritis

21 January 2018

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CD134 plays a crucial role in the pathogenesis of EAE and is upregulated in the CNS of patients with multiple sclerosis

21 January 2018

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Expression of CD134 (0X-40) on T cells during the first 100 days following allogeneic bone marrow transplantation as a marker for lymphocyte activation and therapy-resistant graft-versus-host disease.

21 January 2018

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Expression of T cell activation antigen CD134 (OX40) has no predictive value for the occurrence or response to therapy of acute graft-versus-host disease in partial T cell-depleted bone marrow transplantation

21 January 2018

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The immunological and genetic basis of inflammatory bowel disease

21 January 2018

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Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells

21 January 2018

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Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

21 January 2018

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Interleukin 2 signaling is required for CD4(+) regulatory T cell function

21 January 2018

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A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group.

21 January 2018

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Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40.

21 January 2018

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Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation

21 January 2018

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Differential requirement for CD80 and CD80/CD86-dependent costimulation in the lung immune response to an influenza virus infection

21 January 2018

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The OX-40 receptor provides a potent co-stimulatory signal capable of inducing encephalitogenicity in myelin-specific CD4+ T cells

21 January 2018

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Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

21 January 2018

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OX40-mediated memory T cell generation is TNF receptor-associated factor 2 dependent

21 January 2018

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Engagement of OX40 enhances antigen-specific CD4(+) T cell mobilization/memory development and humoral immunity: comparison of alphaOX-40 with alphaCTLA-4.

21 January 2018

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Signaling through OX40 (CD134) breaks peripheral T-cell tolerance.

21 January 2018

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Augmentation versus inhibition: effects of conjunctional OX-40 receptor monoclonal antibody and IL-2 treatment on adoptive immunotherapy of advanced tumor

21 January 2018

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OX40 ligation enhances primary and memory cytotoxic T lymphocyte responses in an immunotherapy for hepatic colon metastases

21 January 2018

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Induction of anti-mammary cancer immunity by engaging the OX-40 receptor in vivo

21 January 2018

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OX40 ligand-transduced tumor cell vaccine synergizes with GM-CSF and requires CD40-Apc signaling to boost the host T cell antitumor response

21 January 2018

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Immunohistochemical analysis of primary breast tumors and tumor-draining lymph nodes by means of the T-cell costimulatory molecule OX-40.

21 January 2018

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A recombinant vector expressing transgenes for four T-cell costimulatory molecules (OX40L, B7-1, ICAM-1, LFA-3) induces sustained CD4+ and CD8+ T-cell activation, protection from apoptosis, and enhanced cytokine production.

21 January 2018

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Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

21 January 2018

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Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease

21 January 2018

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The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus

21 January 2018

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CD134/OX40 expression by synovial fluid CD4+ T lymphocytes in chronic synovitis.

21 January 2018

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Survival in human colorectal cancer correlates with expression of the T-cell costimulatory molecule OX-40 (CD134).

21 January 2018

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Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor

21 January 2018

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Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34

31 March 2020

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A glycoprotein antigen detected with new monoclonal antibodies on the surface of human lymphocytes infected with human T-cell leukemia virus type-I (HTLV-I).

31 March 2020

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Consequences of OX40-OX40 ligand interactions in langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice

31 March 2020

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The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells

31 March 2020

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Multiple levels of activation of murine CD8(+) intraepithelial lymphocytes defined by OX40 (CD134) expression: effects on cell-mediated cytotoxicity, IFN-gamma, and IL-10 regulation

31 March 2020

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Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion

31 March 2020

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Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis

31 March 2020

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Involvement of OX40-OX40L interactions in the intestinal manifestations of the murine acute graft-versus-host disease

31 March 2020

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Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis

31 March 2020

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Engagement of the OX-40 receptor in vivo enhances antitumor immunity

31 March 2020

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Amelioration of experimental autoimmune encephalomyelitis with anti-OX40 ligand monoclonal antibody: a critical role for OX40 ligand in migration, but not development, of pathogenic T cells

31 March 2020

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Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients

31 March 2020

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Therapeutic effect of anti-OX40L and anti-TNF-alpha MAbs in a murine model of chronic colitis

31 March 2020

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OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophilia

31 March 2020

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Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma

31 March 2020

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The generation of T cell memory: a review describing the molecular and cellular events following OX40 (CD134) engagement

31 March 2020

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CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles

31 March 2020

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Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig

31 March 2020

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Migratory Activity and Functional Changes of Green Fluorescent Effector Cells before and during Experimental Autoimmune Encephalomyelitis

31 March 2020

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Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis

31 March 2020

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Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand

31 March 2020

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Correlation of peripheral blood OX40+(CD134+) T cells with chronic graft-versus-host disease in patients who underwent allogeneic hematopoietic stem cell transplantation

31 March 2020

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Expression of lymphocyte-endothelial receptor-ligand pairs, alpha4beta7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease

31 March 2020

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The expression of OX40 in immunologically mediated diseases of the gastrointestinal tract (celiac disease, Crohn's disease, ulcerative colitis)

31 March 2020

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Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

31 March 2020

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Infliximab in ulcerative colitis: is there a placebo (effect) in the house?

31 March 2020

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Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40

31 March 2020

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OX-40 antibody enhances for autoantigen specific V beta 8.2+ T cells within the spinal cord of Lewis rats with autoimmune encephalomyelitis

31 March 2020

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V beta CDR3 motifs associated with BP recognition are enriched in OX-40+ spinal cord T cells of Lewis rats with EAE

31 March 2020

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Adenovirus vector-mediated in vivo gene transfer of OX40 ligand to tumor cells enhances antitumor immunity of tumor-bearing hosts

31 March 2020

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Alterations in NFkappaB activation in T lymphocytes of patients with renal cell carcinoma

31 March 2020

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Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

31 March 2020

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Expression of OX40 in muscles of polymyositis and granulomatous myopathy

31 March 2020

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Normal IgG protects against acute graft-versus-host disease by targeting CD4+CD134+ donor alloreactive T cells

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1371

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10 August 2017

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