CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha (Q36141679)

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English	CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha	scientific article

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12 August 2017

CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha (English)

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12 August 2017

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Steffen Koschmieder

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Steffen Koschmieder

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Carsten Müller-Tidow

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Carsten Müller-Tidow

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Hagop Kantarjian

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Hagop Kantarjian

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12 August 2017

Marina Konopleva

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Marina Konopleva

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Michael Andreeff

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Michael Andreeff

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Julie C Watt

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Nanjoo Suh

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12 August 2017

Ramasamy Santhanam

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Ramasamy Santhanam

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12 August 2017

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Francesco D'Alò

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12 August 2017

Hanna Radomska

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12 August 2017

Christine Schöneich

4

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12 August 2017

Ji Suk Chang

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12 August 2017

Susumu Kobayashi

7

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12 August 2017

Elena Levantini

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12 August 2017

Annalisa Di Ruscio

10

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12 August 2017

Maria Teresa Voso

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12 August 2017

Bülent Sargin

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12 August 2017

Michael B Sporn

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12 August 2017

Danilo Perrotti

18

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12 August 2017

Wolfgang E Berdel

19

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12 August 2017

Hubert Serve

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Daniel G Tenen

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publication date

1 August 2007

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12 August 2017

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12 August 2017

110

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12 August 2017

10

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12 August 2017

3695-3705

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12 August 2017

High levels of the BCR/ABL oncoprotein are required for the MAPK-hnRNP-E2 dependent suppression of C/EBPalpha-driven myeloid differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077317

2 October 2017

CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms

1 reference

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2 October 2017

C/EBPalpha directs monocytic commitment of primary myeloid progenitors

1 reference

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2 October 2017

A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells

1 reference

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2 October 2017

A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis

1 reference

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2 October 2017

Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.

1 reference

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2 October 2017

2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer

1 reference

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2 October 2017

Effect of transcription-factor concentrations on leukemic stem cells.

1 reference

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2 October 2017

2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor gamma-dependent and -independent pathways

1 reference

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2 October 2017

Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells.

1 reference

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The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia

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The leukemic fusion gene AML1-MDS1-EVI1 suppresses CEBPA in acute myeloid leukemia by activation of Calreticulin

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Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid.

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Peroxisome proliferator-activated receptor-gamma-independent repression of collagenase gene expression by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and prostaglandin 15-deoxy-delta(12,14) J2: a role for Smad signaling

1 reference

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Activation of peroxisome proliferator-activated receptor gamma by a novel synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest and apoptosis in breast cancer cells

1 reference

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2 October 2017

Disruption of differentiation in human cancer: AML shows the way.

1 reference

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2 October 2017

Establishment of the acute myeloid leukemia cell line Kasumi-6 from a patient with a dominant-negative mutation in the DNA-binding region of the C/EBPalpha gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077317

2 October 2017

Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and represses translation of C/EBP proteins

1 reference

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2 October 2017

Transcriptional regulation of granulocyte and monocyte development

1 reference

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2 October 2017

Gene-specific regulation by general translation factors

1 reference

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BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2.

1 reference

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Murine M2-10B4 and SL/SL cell lines differentially affect the balance between CD34+ cell expansion and maturation

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c-Myc is a critical target for c/EBPalpha in granulopoiesis.

1 reference

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AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.

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Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

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A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma

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Translational control of C/EBPalpha and C/EBPbeta isoform expression.

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CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors

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Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice

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Role of the CCAAT/enhancer binding protein-alpha transcription factor in the glucocorticoid stimulation of p21waf1/cip1 gene promoter activity in growth-arrested rat hepatoma cells

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23 September 2018

The novel triterpenoid CDDO and its derivatives induce apoptosis by disruption of intracellular redox balance

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23 September 2018

The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo.

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23 September 2018

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23 September 2018

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Flow cytometric quantification of phagocytosis in acute myeloid leukemia

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The synthetic triterpenoid CDDO-imidazolide induces monocytic differentiation by activating the Smad and ERK signaling pathways in HL60 leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17671235

12 December 2020

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Impaired granulocytic function in patients with acute leukaemia: only partial normalisation after successful remission-inducing treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/17671235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16)

1 reference

https://pubmed.ncbi.nlm.nih.gov/17671235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17671235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2006-11-058941

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Europe PubMed Central

PMC publication ID

12 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

ResearchGate publication ID

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