Notch: a unique therapeutic target for immunomodulation (Q36150879)

12 August 2017

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title

Notch: a unique therapeutic target for immunomodulation (English)

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12 August 2017

Grahame J McKenzie

1

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12 August 2017

Mamnunur Khan

2

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12 August 2017

Emmanuel Briend

3

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12 August 2017

Yvette Stallwood

4

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12 August 2017

Brian R Champion

5

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12 August 2017

language of work or name

English

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publication date

1 April 2005

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Expert Opinion on Therapeutic Targets

12 August 2017

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12 August 2017

9

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12 August 2017

2

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12 August 2017

395-410

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In search of the Holy Grail (actively acquired immunologic tolerance).

12 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Therapeutic aspects of tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Notch signaling: cell fate control and signal integration in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Control of T-cell activation by CD4+ CD25+ suppressor T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Structural conservation of Notch receptors and ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

The Notch1 receptor is cleaved constitutively by a furin-like convertase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Drosophila nicastrin is essential for the intramembranous cleavage of notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

p300 acts as a transcriptional coactivator for mammalian Notch-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Notch1 and T-cell development: insights from conditional knockout mice

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Notch signaling in T- and B-cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

An activated form of Notch influences the choice between CD4 and CD8 T cell lineages

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Functional diversity of helper T lymphocytes

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Suppressor T cells: Rebirth, function and homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Notch 1 signaling regulates peripheral T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Notch signalling in the regulation of peripheral T-cell function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Notch1 is essential for postimplantation development in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Notch1 expression on T cells is not required for CD4+ T helper differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

PKB/AKT: functional insights from genetic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Transcriptional mechanisms underlying lymphocyte tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Evidence that C promoter-binding factor 1 binding is required for Notch-1-mediated repression of activator protein-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Toward the rational design of cell fate modifiers: notch signaling as a target for novel biopharmaceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Powder and particle-mediated approaches for delivery of DNA and protein vaccines into the epidermis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Transferrin-polycation conjugates as carriers for DNA uptake into cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Tolerance and cancer: mechanisms of tumor evasion and strategies for breaking tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Immune modulation by silencing IL-12 production in dendritic cells using small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Fringe is a glycosyltransferase that modifies Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Regulation of notch signaling by o-linked fucose.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

21 January 2018

Chemical glycobiology

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Control of daughter cell fates during asymmetric division: interaction of Numb and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Numb antagonizes Notch signaling to specify sibling neuron cell fates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Neuralized functions as an E3 ubiquitin ligase during Drosophila development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Epsins: adaptors in endocytosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Ubiquitin-protein ligases--novel therapeutic targets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

Notch signaling in lymphocyte development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.395

21 January 2018

Identifiers

DOI

10.1517/14728222.9.2.395

1 reference

12 August 2017

1 reference