Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage (Q36160691)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26384421%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage (English)

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24 February 2020

0 references

1

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24 February 2020

6

Piotr E Marszalek

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24 February 2020

author name string

D Dewran Kocak

2

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24 February 2020

Christopher J Fitzgibbon

3

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24 February 2020

Joshua McMenemy

4

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24 February 2020

Charles A Gersbach

5

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24 February 2020

language of work or name

English

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publication date

17 September 2015

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24 February 2020

published in

Nucleic Acids Research

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24 February 2020

volume

43

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24 February 2020

issue

18

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24 February 2020

page(s)

8924-8941

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Creative Commons Attribution 4.0 International

24 February 2020

copyright license

start time

7 November 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Protospacer adjacent motif (PAM)-distal sequences engage CRISPR Cas9 DNA target cleavage.

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Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

2 October 2017

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Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes.

2 October 2017

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2 October 2017

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Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease.

2 October 2017

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Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

2 October 2017

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Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

2 October 2017

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Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

2 October 2017

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DNA interrogation by the CRISPR RNA-guided endonuclease Cas9.

2 October 2017

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Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

2 October 2017

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Cas9 as a versatile tool for engineering biology

2 October 2017

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Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

2 October 2017

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CRISPR RNA-guided activation of endogenous human genes

2 October 2017

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RNA-guided gene activation by CRISPR-Cas9-based transcription factors

2 October 2017

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DNA targeting specificity of RNA-guided Cas9 nucleases

2 October 2017

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CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes

2 October 2017

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Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression

2 October 2017

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RNA-guided human genome engineering via Cas9

2 October 2017

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Multiplex genome engineering using CRISPR/Cas systems

2 October 2017

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Phage mutations in response to CRISPR diversification in a bacterial population

2 October 2017

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Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

2 October 2017

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

2 October 2017

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Thermodynamic contributions of single internal rA·dA, rC·dC, rG·dG and rU·dT mismatches in RNA/DNA duplexes

2 October 2017

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2 October 2017

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CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Triggered amplification by hybridization chain reaction

2 October 2017

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RNA folding at elementary step resolution

2 October 2017

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DNA hairpins destabilize duplexes primarily by promoting melting rather than by inhibiting hybridization.

2 October 2017

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Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors.

2 July 2018

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2 July 2018

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2 July 2018

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Three-dimensional reconstruction of single particles embedded in ice

2 July 2018

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Flexible guide-RNA design for CRISPR applications using Protospacer Workbench.

2 July 2018

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Directional R-Loop Formation by the CRISPR-Cas Surveillance Complex Cascade Provides Efficient Off-Target Site Rejection.

23 September 2018

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Programmable energy landscapes for kinetic control of DNA strand displacement.

23 September 2018

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Guide RNA functional modules direct Cas9 activity and orthogonality

23 September 2018

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23 September 2018

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23 September 2018

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Relative thermodynamic stability of DNA, RNA, and DNA:RNA hybrid duplexes: relationship with base composition and structure.

23 September 2018

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23 September 2018

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Crossref

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Improved nearest-neighbor parameters for predicting DNA duplex stability

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/26384421

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Thermodynamic parameters to predict stability of RNA/DNA hybrid duplexes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26384421

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Thermodynamics-structure relationship of single mismatches in RNA/DNA duplexes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26384421

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKV892

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26384421%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26384421%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

26384421

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26384421%20AND%20SRC:MED&resulttype=core&format=json