An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats (Q36182494)

12 August 2017

An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats (English)

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12 August 2017

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Abishek Iyer

1

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12 August 2017

Junxian Lim

2

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12 August 2017

Hemant Poudyal

3

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12 August 2017

Robert C Reid

4

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12 August 2017

Jacky Y Suen

5

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12 August 2017

Julie Webster

6

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12 August 2017

Johannes B Prins

7

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12 August 2017

Jonathan P Whitehead

8

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12 August 2017

David P Fairlie

9

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12 August 2017

Lindsay Brown

10

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12 August 2017

language of work or name

English

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publication date

1 September 2012

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12 August 2017

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12 August 2017

61

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12 August 2017

2320-2329

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12 August 2017

9

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

12 August 2017

start time

27 August 2021

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3425408/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

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1 October 2017

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Genetic ablation of calcium-independent phospholipase A2gamma prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation

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Mice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet

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Alleviation of high-fat diet-induced fatty liver damage in group IVA phospholipase A2-knockout mice

1 October 2017

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CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

1 October 2017

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Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

1 October 2017

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Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

1 October 2017

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AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency

1 October 2017

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Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA)

1 October 2017

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Dynamics of fat cell turnover in humans

1 October 2017

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Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

1 October 2017

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Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

1 October 2017

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Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha

1 October 2017

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

1 October 2017

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1 October 2017

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Inflammation and metabolic disorders

1 October 2017

1 reference

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Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome

1 October 2017

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PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism

1 October 2017

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

1 October 2017

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Obesity is associated with macrophage accumulation in adipose tissue

1 October 2017

1 reference

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Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist

1 October 2017

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D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity

1 October 2017

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Secretory, endocrine and autocrine/paracrine function of the adipocyte

1 October 2017

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Arachidonic acid and PGE2 regulation of hepatic lipogenic gene expression

1 October 2017

1 reference

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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

1 October 2017

1 reference

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Reduced expression of the liver/beta-cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic rats

1 October 2017

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Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2 A resolution

1 October 2017

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Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate

1 October 2017

1 reference

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Transcellular prostaglandin production following mast cell activation is mediated by proximal secretory phospholipase A2 and distal prostaglandin synthase 1.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425408

Group IVA phospholipase A2 is associated with the storage of lipids in adipose tissue and liver.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425408

Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425408

A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3425408

Antifibrotic Activity of an Inhibitor of Group IIA Secretory Phospholipase A2 in Young Spontaneously Hypertensive Rats

23 September 2018

1 reference

12 December 2020

Adipose lipid turnover—a new target in metabolic disease

1 reference

12 December 2020

High-carbohydrate, high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats

1 reference

12 December 2020

Prostanoid-induced inhibition of lipolysis in rat isolated adipocytes: probable involvement of EP3 receptors

1 reference

12 December 2020

Lipid redistribution by α-linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats

1 reference

12 December 2020

Linking the inflammasome to obesity-related disease

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB11-1179

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12 August 2017

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12 August 2017

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