Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate (Q36184405)

12 August 2017

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title

Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate (English)

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12 August 2017

1

Harald von Boehmer

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12 August 2017

publication date

1 July 2005

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Nature Reviews Immunology

12 August 2017

published in

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12 August 2017

volume

5

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12 August 2017

issue

7

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12 August 2017

page(s)

571-577

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Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.

12 August 2017

cites work

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Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

21 January 2018

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Rearrangement and diversity of T cell receptor beta chain genes in thymocytes: a critical role for the beta chain in development

21 January 2018

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A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein

21 January 2018

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Analysis and expression of a cloned pre-T cell receptor gene

21 January 2018

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Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development

21 January 2018

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Genomic structure and chromosomal location of the mouse pre-T-cell receptor alpha gene

21 January 2018

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Cloning and comparative analysis of the human pre-T-cell receptor alpha-chain gene

21 January 2018

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The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire

21 January 2018

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Expression of the mouse pre-T cell receptor alpha gene is controlled by an upstream region containing a transcriptional enhancer

21 January 2018

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The upstream enhancer is necessary and sufficient for the expression of the pre-T cell receptor alpha gene in immature T lymphocytes

21 January 2018

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Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway

21 January 2018

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Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice

21 January 2018

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Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential.

21 January 2018

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Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

21 January 2018

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Deficient T cell fate specification in mice with an induced inactivation of Notch1.

21 January 2018

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Constitutive endocytosis and degradation of the pre-T cell receptor.

21 January 2018

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Role of different T cell receptors in the development of pre-T cells.

21 January 2018

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Intrathymic delta selection events in gammadelta cell development.

21 January 2018

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The developmental fate of T cells is critically influenced by TCRgammadelta expression.

21 January 2018

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T-cell receptor gamma delta and gamma transgenic mice suggest a role of a gamma gene silencer in the generation of alpha beta T cells.

21 January 2018

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A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation

21 January 2018

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A critical role of λ5 protein in B cell development

21 January 2018

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Thymic selection revisited: how essential is it?

21 January 2018

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On the role of the pre-T cell receptor in alphabeta versus gammadelta T lineage commitment

21 January 2018

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Biased V beta usage in immature thymocytes is independent of DJ beta proximity and pT alpha pairing.

21 January 2018

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In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes.

21 January 2018

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The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci

21 January 2018

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Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta tra

21 January 2018

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Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus.

21 January 2018

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Surrogate Light Chain Expression Is Required to Establish Immunoglobulin Heavy Chain Allelic Exclusion during Early B Cell Development

21 January 2018

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Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains

21 January 2018

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Different initiation of pre-TCR and gammadeltaTCR signalling

21 January 2018

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Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein

21 January 2018

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The biological activity of natural and mutant pTalpha alleles

21 January 2018

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Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha.

21 January 2018

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The nonimmunoglobulin portion of lambda5 mediates cell-autonomous pre-B cell receptor signaling

21 January 2018

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Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation

21 January 2018

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Selection of the T-cell repertoire: receptor-controlled checkpoints in T-cell development

21 January 2018

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Regulation of thymocyte differentiation: pre-TCR signals and beta-selection

21 January 2018

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Calcineurin B1 is essential for positive but not negative selection during thymocyte development

21 January 2018

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The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locus

21 January 2018

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The function of E- and Id proteins in lymphocyte development

21 January 2018

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Requirement for cyclin D3 in lymphocyte development and T cell leukemias

21 January 2018

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Coming to grips with Notch

21 January 2018

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Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis

21 January 2018

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

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Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

21 January 2018

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Early deletion and late positive selection of T cells expressing a male-specific receptor in T-cell receptor transgenic mice

21 January 2018

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The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells.

21 January 2018

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Premature expression of T cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells

21 January 2018

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In-frame TCR delta gene rearrangements play a critical role in the alpha beta/gamma delta T cell lineage decision.

21 January 2018

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Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment

21 January 2018

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Expression of T-cell antigen receptor genes during fetal development in the thymus

21 January 2018

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Developmental regulation of T-cell receptor gene expression

21 January 2018

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Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

21 January 2018

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Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells

21 January 2018

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Genomic structure of the human pre-T cell receptor alpha chain and expression of two mRNA isoforms

31 March 2020

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Intra- and extra-thymic expression of the pre-T cell receptor alpha gene

31 March 2020

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Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene

31 March 2020

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Competitive displacement of pT alpha by TCR-alpha during TCR assembly prevents surface coexpression of pre-TCR and alpha beta TCR

31 March 2020

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Function of the TCR alpha enhancer in alphabeta and gammadelta T cells

31 March 2020

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Gamma delta T cells promote CD4 and CD8 expression by SCID thymocytes

31 March 2020

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Changes in the V(H) gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor

31 March 2020

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Precursor B cells showing H chain allelic inclusion display allelic exclusion at the level of pre-B cell receptor surface expression

31 March 2020

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A critical role for the cytoplasmic tail of pTα in T lymphocyte development

31 March 2020

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A new spin on an unusual tail

31 March 2020

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NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development

31 March 2020

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Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1636

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12 August 2017

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