Transition metals activate TFEB in overexpressing cells (Q36184709)

12 August 2017

Transition metals activate TFEB in overexpressing cells (English)

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12 August 2017

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Karina A Peña

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12 August 2017

Kirill Kiselyov

series ordinal

2

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12 August 2017

language of work or name

English

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publication date

11 June 2015

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12 August 2017

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12 August 2017

470

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12 August 2017

1

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12 August 2017

65-76

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describes a project that uses

12 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4613523/fullTextXML

inferred from PubMed Central ID database lookup

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Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover

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Wilson disease protein ATP7B utilizes lysosomal exocytosis to maintain copper homeostasis.

1 October 2017

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Zn2+ efflux through lysosomal exocytosis prevents Zn2+-induced toxicity

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1 October 2017

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Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease

1 October 2017

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Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis

1 October 2017

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The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris

1 October 2017

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GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy

1 October 2017

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A delicate balance: Iron metabolism and diseases of the brain.

1 October 2017

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1 October 2017

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What else is in store for autophagy? Exocytosis of autolysosomes as a mechanism of TFEB-mediated cellular clearance in Pompe disease

1 October 2017

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TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity

1 October 2017

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Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease

1 October 2017

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An extended proteome map of the lysosomal membrane reveals novel potential transporters

1 October 2017

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Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes

1 October 2017

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Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency

1 October 2017

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Zinc-dependent lysosomal enlargement in TRPML1-deficient cells involves MTF-1 transcription factor and ZnT4 (Slc30a4) transporter

1 October 2017

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The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis

1 October 2017

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MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.

1 October 2017

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Chelating agents for neurodegenerative diseases

1 October 2017

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A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

1 October 2017

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Iron dysregulation in movement disorders

1 October 2017

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Loss of lysosomal ion channel transient receptor potential channel mucolipin-1 (TRPML1) leads to cathepsin B-dependent apoptosis

1 October 2017

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The role of metallobiology and amyloid-β peptides in Alzheimer's disease

1 October 2017

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Copper: an essential metal in biology

1 October 2017

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The neurophysiology and pathology of brain zinc

1 October 2017

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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

1 October 2017

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Transcriptional activation of lysosomal exocytosis promotes cellular clearance

1 October 2017

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Zinc: new clues to diverse roles in brain ischemia

1 October 2017

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TFEB links autophagy to lysosomal biogenesis

1 October 2017

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Iron, zinc and copper in the Alzheimer's disease brain: a quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion

1 October 2017

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Transition metal homeostasis: from yeast to human disease.

1 October 2017

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Oxidative genome damage and its repair in neurodegenerative diseases: function of transition metals as a double-edged sword

1 October 2017

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Interactions of Zn(II) and Cu(II) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity

1 October 2017

1 reference

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Zinc dyshomeostasis is linked with the loss of mucolipidosis IV-associated TRPML1 ion channel

1 October 2017

1 reference

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Functional analysis of two single nucleotide polymorphisms in SLC30A2 (ZnT2): implications for mammary gland function and breast disease in women

1 October 2017

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An integrated imaging approach to the study of oxidative stress generation by mitochondrial dysfunction in living cells

1 October 2017

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1 October 2017

Copper metallochaperones

1 reference

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Mammalian iron metabolism

1 October 2017

1 reference

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Risks of copper and iron toxicity during aging in humans

1 October 2017

1 reference

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A gene network regulating lysosomal biogenesis and function

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Zinc transporter-2 (ZnT2) variants are localized to distinct subcellular compartments and functionally transport zinc

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Zinc and diabetes--clinical links and molecular mechanisms

1 October 2017

1 reference

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Superoxide is the major reactive oxygen species regulating autophagy

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Lysosomes in iron metabolism, ageing and apoptosis

1 October 2017

1 reference

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The role of zinc in cerebral ischemia

1 October 2017

1 reference

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The role of metals in the etiology of Alzheimer's disease.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Autophagy, mitochondria and cell death in lysosomal storage diseases.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Compound overload of copper and iron in patients with Wilson's disease

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Mechanisms of the copper-dependent turnover of the copper chaperone for superoxide dismutase

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Molecular regulation of copper excretion in the liver

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Stroke: molecular mechanisms and potential targets for treatment.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Mechanisms and regulation of intestinal iron absorption

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Copper metabolic defects and liver disease: environmental aspects

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

The molecular basis of copper homeostasis copper-related disorders

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Lysosomal involvement in hepatocyte cytotoxicity induced by Cu(2+) but not Cd(2+).

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Cellular copper transport and metabolism

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Heavy metal-mediated activation of the rat Cu/Zn superoxide dismutase gene via a metal-responsive element

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Oxygen toxicity, oxygen radicals, transition metals and disease

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

PPARGC1A/PGC-1α, TFEB and enhanced proteostasis in Huntington disease: defining regulatory linkages between energy production and protein-organelle quality control

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Lysosomal positioning coordinates cellular nutrient responses.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Loss of TRPML1 promotes production of reactive oxygen species: is oxidative damage a factor in mucolipidosis type IV?

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Mitochondrial inhibitor models of Huntington's disease and Parkinson's disease induce zinc accumulation and are attenuated by inhibition of zinc neurotoxicity in vitro or in vivo

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

ZnT2-overexpression represses the cytotoxic effects of zinc hyper-accumulation in malignant metallothionein-null T47D breast tumor cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Transporters in the absorption and utilization of zinc and copper

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Evaluation of copper toxicity in isolated human peripheral blood mononuclear cells and it's attenuation by zinc: ex vivo.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Neurodegenerative diseases and oxidative stress

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Effects of aluminum and zinc on the oxidative stress caused by 6-hydroxydopamine autoxidation: relevance for the pathogenesis of Parkinson's disease.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613523

Copper toxicity affects proliferation and viability of human hepatoma cells (HepG2 line)

23 September 2018

1 reference

12 December 2020

Autophagy and neurodegeneration

1 reference

12 December 2020

Introduction to Human Disorders of Copper Metabolism

1 reference

12 December 2020

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1 reference

12 December 2020

Identifiers

DOI

10.1042/BJ20140645

1 reference

12 August 2017

1 reference

12 August 2017

1 reference