AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells. (Q36207311)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22728651%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells (English)

1 reference

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6 February 2020

1 reference

1 reference

7

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6 February 2020

Irene Oi-lin Ng

8

1 reference

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6 February 2020

author name string

Chi-Wai Lee

1

1 reference

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6 February 2020

Leo Lap-Yan Wong

2

1 reference

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6 February 2020

Edith Yuk-Ting Tse

3

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6 February 2020

Heong-Fai Liu

4

1 reference

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6 February 2020

Veronica Yee-Law Leong

5

1 reference

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6 February 2020

Joyce Man-Fong Lee

6

1 reference

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6 February 2020

Yick-Pang Ching

9

1 reference

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6 February 2020

language of work or name

English

0 references

publication date

22 June 2012

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6 February 2020

1 reference

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6 February 2020

volume

72

1 reference

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6 February 2020

page(s)

4394-4404

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6 February 2020

issue

17

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AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

6 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

AMP-activated protein kinase: also regulated by ADP?

1 October 2017

1 reference

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Mitochondria and cell death: outer membrane permeabilization and beyond

1 October 2017

1 reference

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The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

JNK1 phosphorylates SIRT1 and promotes its enzymatic activity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

1 October 2017

1 reference

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Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt

1 October 2017

1 reference

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

1 October 2017

1 reference

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Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

Sirtuins: critical regulators at the crossroads between cancer and aging

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

Cytoplasm-localized SIRT1 enhances apoptosis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

The p53 network: p53 and its downstream genes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

Chromosomal instability and human hepatocarcinogenesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

Structure of a Sir2 enzyme bound to an acetylated p53 peptide

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

Negative control of p53 by Sir2alpha promotes cell survival under stress

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

Crystal structure of a SIR2 homolog-NAD complex

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

Sir2 links chromatin silencing, metabolism, and aging

1 October 2017

1 reference

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Histone deacetylases specifically down-regulate p53-dependent gene activation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

DNA damage activates p53 through a phosphorylation-acetylation cascade

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

1 October 2017

1 reference

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Analysis of the specificity of the AMP-activated protein kinase by site-directed mutagenesis of bacterially expressed 3-hydroxy 3-methylglutaryl-CoA reductase, using a single primer variant of the unique-site-elimination method

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

Identification of an autoinhibitory domain of p21-activated protein kinase 5.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433393

[A preliminary study of loss of heterozygosity on chromosome 1p in primary hepatocellular carcinoma]

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22728651

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Comparative and pharmacophore model for deacetylase SIRT1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22728651

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-12-0429

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22728651%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22728651%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference