Role of altered signal transduction in heterotopic ossification and fibrodysplasia ossificans progressiva (Q36208494)

12 August 2017

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title

Role of altered signal transduction in heterotopic ossification and fibrodysplasia ossificans progressiva (English)

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fibrodysplasia ossificans progressiva

12 August 2017

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author name string

Eileen M Shore

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1

1 reference

PMCID

3433752

12 August 2017

Frederick S Kaplan

series ordinal

2

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PMCID

3433752

12 August 2017

language of work or name

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1 June 2011

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Current osteoporosis reports

12 August 2017

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12 August 2017

9

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12 August 2017

2

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12 August 2017

83-88

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https://scigraph.springernature.com/pub.10.1007/s11914-011-0046-3

12 August 2017

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Molecular consequences of the ACVR1(R206H) mutation of fibrodysplasia ossificans progressiva.

1 October 2017

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ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP-induced osteoblast differentiation and bone formation

1 October 2017

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The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization

1 October 2017

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Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients

1 October 2017

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Tgf-beta superfamily signaling in embryonic development and homeostasis

1 October 2017

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Identification of progenitor cells that contribute to heterotopic skeletogenesis

1 October 2017

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Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1

1 October 2017

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BMP type I receptor inhibition reduces heterotopic [corrected] ossification

1 October 2017

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1 October 2017

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Mutational analysis of the ACVR1 gene in Italian patients affected with fibrodysplasia ossificans progressiva: confirmations and advancements.

1 October 2017

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Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva.

1 October 2017

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Integrating positional information at the level of Smad1/5/8.

1 October 2017

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1 October 2017

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TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility

1 October 2017

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Dysregulated BMP signaling and enhanced osteogenic differentiation of connective tissue progenitor cells from patients with fibrodysplasia ossificans progressiva (FOP).

1 October 2017

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A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva

1 October 2017

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1 October 2017

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ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development

1 October 2017

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1 October 2017

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Incidence of heterotopic bone formation after major hip surgery

1 October 2017

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1 October 2017

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The TGF beta receptor activation process: an inhibitor- to substrate-binding switch

1 October 2017

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Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva

1 October 2017

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Bone: formation by autoinduction

1 October 2017

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Hypoxic adipocytes pattern early heterotopic bone formation.

1 October 2017

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Heterotopic ossification in high-energy wartime extremity injuries: prevalence and risk factors.

29 June 2018

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Fibrodysplasia ossificans progressiva (FOP), a disorder of ectopic osteogenesis, misregulates cell surface expression and trafficking of BMPRIA.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11914-011-0046-3

Differentiation plasticity regulated by TGF-beta family proteins in development and disease

21 January 2018

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In vivo somatic cell gene transfer of an engineered Noggin mutein prevents BMP4-induced heterotopic ossification

21 January 2018

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Bone formation and inflammation in cardiac valves

22 September 2018

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12 December 2020

Stromal cells of fibrodysplasia ossificans progressiva lesions express smooth muscle lineage markers and the osteogenic transcription factor Runx2/Cbfa-1: clues to a vascular origin of heterotopic ossification?

1 reference

12 December 2020

Observations on the induction of bone in soft tissues

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12 December 2020

The histopathology of fibrodysplasia ossificans progressiva. An endochondral process

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12 December 2020

Acute lymphocytic infiltration in an extremely early lesion of fibrodysplasia ossificans progressiva

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12 December 2020

Heterotopic ossification: a review

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12 December 2020

Dysregulation of the BMP-p38 MAPK signaling pathway in cells from patients with fibrodysplasia ossificans progressiva (FOP)

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12 December 2020

Hematopoietic stem-cell contribution to ectopic skeletogenesis

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12 December 2020

Functional modeling of the ACVR1 (R206H) mutation in FOP

1 reference

12 December 2020

10.1007/S11914-011-0046-3

Identifiers

DOI

1 reference

12 August 2017

1 reference

12 August 2017

1 reference

PMCID

3433752