Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome. (Q36212795)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22891354%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22891354%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

0 references

7

1 reference

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11 February 2020

Rubén Deogracias

1

1 reference

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11 February 2020

Martijn P J Dekkers

3

1 reference

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11 February 2020

Jacky Guy

4

1 reference

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11 February 2020

author name string

Morteza Yazdani

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22891354%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Mihai Constantin S Ionescu

5

1 reference

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11 February 2020

Kaspar E Vogt

6

1 reference

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11 February 2020

language of work or name

English

0 references

publication date

13 August 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22891354%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

11 February 2020

number of pages

6

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22891354%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

volume

109

1 reference

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11 February 2020

issue

35

1 reference

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11 February 2020

page(s)

14230-14235

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22891354%20AND%20SRC:MED&resulttype=core&format=json

BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons

11 February 2020

cites work

1 reference

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1 October 2017

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A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome

1 October 2017

1 reference

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S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis

1 October 2017

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Potential therapeutic uses of BDNF in neurological and psychiatric disorders

1 October 2017

1 reference

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FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

1 October 2017

1 reference

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Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

1 October 2017

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Fingolimod is a potential novel therapy for multiple sclerosis

1 October 2017

1 reference

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Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms

1 October 2017

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Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats.

1 October 2017

1 reference

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Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice

1 October 2017

1 reference

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Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

1 October 2017

1 reference

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From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function

1 October 2017

1 reference

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Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis

1 October 2017

1 reference

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Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome.

1 October 2017

1 reference

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Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis

1 October 2017

1 reference

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Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene

1 October 2017

1 reference

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Structural and functional characteristics of S1P receptors.

1 October 2017

1 reference

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The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

1 October 2017

1 reference

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Function and regulation of CREB family transcription factors in the nervous system

1 October 2017

1 reference

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Calcium regulation of neuronal gene expression

1 October 2017

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Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

1 October 2017

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A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

1 October 2017

1 reference

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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

1 October 2017

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Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5

1 October 2017

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Purification of a new neurotrophic factor from mammalian brain

1 October 2017

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Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain

1 October 2017

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Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth.

1 October 2017

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29 June 2018

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29 June 2018

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29 June 2018

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29 June 2018

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Hippocampal enlargement in Bassoon-mutant mice is associated with enhanced neurogenesis, reduced apoptosis, and abnormal BDNF levels.

29 June 2018

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22 September 2018

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Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors.

22 September 2018

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The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression.

22 September 2018

1 reference

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Transcription of the NR1 subunit of the N-methyl-D-aspartate receptor is down-regulated by excitotoxic stimulation and cerebral ischemia.

22 September 2018

1 reference

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Differentiation of mouse embryonic stem cells into a defined neuronal lineage

22 September 2018

1 reference

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Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor.

22 September 2018

1 reference

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Fgfr3 expression by astrocytes and their precursors: evidence that astrocytes and oligodendrocytes originate in distinct neuroepithelial domains

22 September 2018

1 reference

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Temporal interaction between single spikes and complex spike bursts in hippocampal pyramidal cells

22 September 2018

1 reference

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Brain-derived neurotrophic factor levels in the nervous system of wild-type and neurotrophin gene mutant mice.

22 September 2018

1 reference

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Evidence that brain-derived neurotrophic factor neuroprotection is linked to its ability to reverse the NMDA-induced inactivation of protein kinase C in cortical neurons.

22 September 2018

1 reference

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Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons.

22 September 2018

1 reference

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Picrotoxin convulsions involve synaptic and nonsynaptic mechanisms on cultured mouse spinal neurons

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22891354

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1206093109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22891354%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

0 references

1 reference

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11 February 2020

1 reference

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