Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2. (Q36224634)

12 August 2017

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2. (English)

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12 August 2017

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4

David M Sabatini

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12 August 2017

Lan Ye

1

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12 August 2017

Behzad Varamini

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2

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12 August 2017

Dudley W Lamming

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3

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12 August 2017

Joseph A Baur

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5

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12 August 2017

language of work or name

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11 September 2012

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12 August 2017

Frontiers in Genetics

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12 August 2017

3

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12 August 2017

177

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describes a project that uses

12 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3438685/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Yin Yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling.

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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

1 October 2017

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Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics

1 October 2017

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Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons

1 October 2017

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Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

1 October 2017

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Diacylglycerol-mediated insulin resistance

1 October 2017

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Metformin supplementation and life span in Fischer-344 rats

1 October 2017

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Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue

1 October 2017

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Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells

1 October 2017

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Direct control of mitochondrial function by mTOR.

1 October 2017

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mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

1 October 2017

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FKBP12.6-knockout mice display hyperinsulinemia and resistance to high-fat diet-induced hyperglycemia

1 October 2017

1 reference

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

1 October 2017

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Calorie restriction and dwarf mice in gerontological research

1 October 2017

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Increasing longevity through caloric restriction or rapamycin feeding in mammals: common mechanisms for common outcomes?

1 October 2017

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

1 October 2017

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Short-term calorie restriction in male mice feminizes gene expression and alters key regulators of conserved aging regulatory pathways

1 October 2017

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mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

1 October 2017

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

1 October 2017

1 reference

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Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

1 October 2017

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

1 October 2017

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FKBP12.6 disruption impairs glucose-induced insulin secretion

1 October 2017

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mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

1 October 2017

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

1 October 2017

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Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

1 October 2017

1 reference

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438685

The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity

1 October 2017

1 reference

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 October 2017

1 reference

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Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

1 October 2017

1 reference

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Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling

1 October 2017

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 October 2017

1 reference

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

1 October 2017

1 reference

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Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle

1 October 2017

1 reference

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

1 October 2017

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Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice

1 October 2017

1 reference

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RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1 October 2017

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The Turnover of Mitochondria in a Variety of Tissues of Young Adult and Aged Rats

1 October 2017

1 reference

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Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438685

Resveratrol inhibits insulin responses in a SirT1-independent pathway

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438685

Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438685

Impact of long-term caloric restriction on cardiac senescence: caloric restriction ameliorates cardiac diastolic dysfunction associated with aging.

29 June 2018

1 reference

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Management of side effects of sirolimus therapy

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438685

Tacrolimus and sirolimus cause insulin resistance in normal sprague dawley rats.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438685

Glucose metabolism in renal transplant recipients: effect of calcineurin inhibitor withdrawal and conversion to sirolimus

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438685

Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3438685

22 September 2018

Identifiers

DOI

10.3389/FGENE.2012.00177

1 reference

12 August 2017

1 reference

12 August 2017

1 reference