Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling (Q40445604)

20 September 2017

Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling (English)

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20 September 2017

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5

Scott A Summers

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20 September 2017

Jose Antonio Chavez

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20 September 2017

William L Holland

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2

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20 September 2017

Julia Bär

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3

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20 September 2017

Konrad Sandhoff

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4

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20 September 2017

language of work or name

English

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publication date

17 March 2005

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Journal of Biological Chemistry

20 September 2017

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20 September 2017

280

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20 September 2017

20148-20153

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20 September 2017

20

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New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

20 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

The metabolic syndrome X.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

The IRS-signalling system: a network of docking proteins that mediate insulin action

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Role of Akt/protein kinase B in metabolism.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Cross-talk mechanisms in the development of insulin resistance of skeletal muscle cells palmitate rather than tumour necrosis factor inhibits insulin-dependent protein kinase B (PKB)/Akt stimulation and glucose uptake

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412769200

Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Overexpressing human lipoprotein lipase in mouse skeletal muscle is associated with insulin resistance

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Ceramides and sphingomyelins in skeletal muscles of the rat: content and composition. Effect of prolonged exercise.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

The role of intramuscular lipid in insulin resistance

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Biosynthesis of sphingolipids: dihydroceramide and not sphinganine is desaturated by cultured cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification Of the first molecular lesion causing Farber disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Differentiation-dependent suppression of platelet-derived growth factor signaling in cultured adipocytes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Enzymatic measurement of sphingosine 1-phosphate.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Inhibitory action of sphingosine, sphinganine and dexamethasone on glucose uptake: studies with hydrogen peroxide and phorbol ester

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Sphingolipids inhibit insulin and phorbol ester stimulated uptake of 2-deoxyglucose

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Signaling pathways mediating insulin-stimulated glucose transport

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412769200

Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Human acid ceramidase is overexpressed but not mutated in prostate cancer

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Cloning and characterization of the full-length cDNA and genomic sequences encoding murine acid ceramidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412769200

Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Ceramide content is increased in skeletal muscle from obese insulin-resistant humans

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

Exercise and training effects on ceramide metabolism in human skeletal muscle.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M412769200

21 January 2018

Identifiers

DOI

10.1074/JBC.M412769200

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20 September 2017

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