Development of Small Molecules with a Noncanonical Binding Mode to HIV-1 Trans Activation Response (TAR) RNA. (Q36230686)

8 January 2018

title

Development of Small Molecules with a Noncanonical Binding Mode to HIV-1 Trans Activation Response (TAR) RNA. (English)

1 reference

8 January 2018

author

Joanna Sztuba-Solińska

3

object named as

Joanna Sztuba-Solinska

1 reference

8 January 2018

Fardokht A Abulwerdi

1

1 reference

8 January 2018

Matthew D Shortridge

2

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8 January 2018

Robert Wilson

4

1 reference

8 January 2018

Stuart F J Le Grice

5

1 reference

8 January 2018

Gabriele Varani

6

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8 January 2018

John S Schneekloth

7

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8 January 2018

language of work or name

English

0 references

publication date

2 December 2016

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8 January 2018

Journal of Medicinal Chemistry

published in

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8 January 2018

volume

59

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8 January 2018

issue

24

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8 January 2018

page(s)

11148-11160

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8 January 2018

Tertiary Element Interaction in HIV-1 TAR.

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Identification of biologically active, HIV TAR RNA-binding small molecules using small molecule microarrays

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Regulation of host gene expression by HIV-1 TAR microRNAs.

29 June 2018

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Thermodynamic studies of a series of homologous HIV-1 TAR RNA ligands reveal that loose binders are stronger Tat competitors than tight ones.

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HIV-1 TAR miRNA protects against apoptosis by altering cellular gene expression

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How binding of small molecule and peptide ligands to HIV-1 TAR alters the RNA motional landscape

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High-throughput SHAPE analysis reveals structures in HIV-1 genomic RNA strongly conserved across distinct biological states

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Structure-activity relationships in the binding of chemically derivatized CD4 to gp120 from human immunodeficiency virus

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HIV-1 TAR element is processed by Dicer to yield a viral micro-RNA involved in chromatin remodeling of the viral LTR

29 June 2018

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Ligand-induced changes in 2-aminopurine fluorescence as a probe for small molecule binding to HIV-1 TAR RNA

29 June 2018

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Evidence for a base triple in the free HIV-1 TAR RNA.

29 June 2018

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RNA interactions in the 5' region of the HIV-1 genome

29 June 2018

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29 June 2018

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Mutations in the TAR hairpin affect the equilibrium between alternative conformations of the HIV-1 leader RNA

29 June 2018

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Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B

29 June 2018

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A new class of HIV-1 Tat antagonist acting through Tat-TAR inhibition

29 June 2018

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Binding of Hoechst 33258 to the TAR RNA of HIV-1. Recognition of a pyrimidine bulge-dependent structure

29 June 2018

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Tat is required for efficient HIV-1 reverse transcription

29 June 2018

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A critical role for the TAR element in promoting efficient human immunodeficiency virus type 1 reverse transcription

29 June 2018

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The structure of the human immunodeficiency virus type-1 TAR RNA reveals principles of RNA recognition by Tat protein

29 June 2018

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trans activation of human immunodeficiency virus type 1 is sequence specific for both the single-stranded bulge and loop of the trans-acting-responsive hairpin: a quantitative analysis.

29 June 2018

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Tat trans-activates the human immunodeficiency virus through a nascent RNA target

29 June 2018

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Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro

29 June 2018

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HIV-1 tat protein stimulates transcription by binding to a U-rich bulge in the stem of the TAR RNA structure

29 June 2018

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Structural features in TAR RNA of human and simian immunodeficiency viruses: a phylogenetic analysis

29 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5525537

Three-dimensional RNA structure of the major HIV-1 packaging signal region

29 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5525537

Architecture of a gamma retroviral genomic RNA dimer.

22 September 2018

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a high-throughput screening utilizing intramolecular fluorescence resonance energy transfer for the discovery of the molecules that bind hiv-1 tar rna specifically

22 September 2018

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TAR RNA recognition by a cyclic peptidomimetic of Tat protein

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Discovery of indeno[1,2-c]quinoline derivatives as inhibitors of osteoclastogenesis induced by receptor activator of NF-κB ligand (RANKL)

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Conformation of the TAR RNA-Arginine Complex by NMR Spectroscopy

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Synthesis and antifungal activity of 3-(1,3,4-oxadiazol-5-yl)-indoles and 3-(1,3,4-oxadiazol-5-yl)methyl-indoles

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Unexpected Diels–Alder/Carbonyl-ene Cascade toward the Biomimetic Synthesis of Chloropupukeananin

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Identifiers

DOI

1 reference

8 January 2018

PMCID

5525537

1 reference

8 January 2018

PubMed ID

28002966

1 reference

8 January 2018