Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization (Q36267045)

13 August 2017

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization (English)

1 reference

cryogenic electron microscopy

13 August 2017

0 references

NLR family, apoptosis inhibitory protein 5

1 reference

GOA release 2020-03-11

Caspase 1

1 reference

NLR family, CARD domain containing 4

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

Alvin Lu

9

0 references

Youdong Mao

object named as

Youdong Mao

14

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author name string

Liman Zhang

1

1 reference

13 August 2017

Shuobing Chen

2

1 reference

13 August 2017

Jianbin Ruan

3

1 reference

13 August 2017

Jiayi Wu

4

1 reference

13 August 2017

Alexander B Tong

5

1 reference

13 August 2017

Qian Yin

6

1 reference

13 August 2017

Yang Li

7

1 reference

13 August 2017

Liron David

8

1 reference

13 August 2017

Wei Li Wang

10

1 reference

13 August 2017

Carolyn Marks

11

1 reference

13 August 2017

Qi Ouyang

12

1 reference

13 August 2017

Xinzheng Zhang

13

1 reference

13 August 2017

Hao Wu

15

1 reference

13 August 2017

language of work or name

English

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publication date

8 October 2015

1 reference

13 August 2017

1 reference

13 August 2017

350

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13 August 2017

6259

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13 August 2017

404-409

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Structural and biochemical basis for induced self-propagation of NLRC4.

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

An inherited mutation in NLRC4 causes autoinflammation in human and mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Beneficial and Detrimental Roles of NLRs in Carcinogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Crystal structure of NLRC4 reveals its autoinhibition mechanism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Higher-order assemblies in a new paradigm of signal transduction

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Apoptosome structure, assembly, and procaspase activation.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellin.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific immune responses

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Structure of the Drosophila Apoptosome at 6.9 Å Resolution

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

The Nod-like receptor (NLR) family: a tale of similarities and differences

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

High-resolution genetic and physical map of the Lgn1 interval in C57BL/6J implicates Naip2 or Naip5 in Legionella pneumophila pathogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Comparative protein structure modeling of genes and genomes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

A new model for the transition of APAF-1 from inactive monomer to caspase-activating apoptosome

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640189

Transfer-PCR (TPCR): a highway for DNA cloning and protein engineering

22 September 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC5789

Automated molecular microscopy: the new Leginon system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC5789

Accurate determination of local defocus and specimen tilt in electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC5789

EMAN2: an extensible image processing suite for electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC5789

SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC5789

RELION: implementation of a Bayesian approach to cryo-EM structure determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC5789

Prevention of overfitting in cryo-EM structure determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC5789

Bsoft: image processing and molecular modeling for electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC5789

UCSF Chimera--a visualization system for exploratory research and analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC5789

PHENIX: a comprehensive Python-based system for macromolecular structure solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC5789

Inference of macromolecular assemblies from crystalline state

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC5789

Site-specific C-terminal and internal loop labeling of proteins using sortase-mediated reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC5789

STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: multiple, complex domain architectures, unusual phyletic patterns, and evolution by horizontal gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC5789

Wheel of Life, Wheel of Death: A Mechanistic Insight into Signaling by STAND Proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC5789

Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26449474

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.AAC5789

1 reference

13 August 2017

1 reference

13 August 2017

1 reference